INT116970

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2011
Negated 1
Speculated 4
Reported most in Body
Documents 50
Total Number 54
Disease Relevance 70.54
Pain Relevance 15.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL20) extracellular space (CCL20) extracellular region (CCL20)
cell-cell signaling (CCL20)
Anatomy Link Frequency
dendritic cells 2
epithelial cells 2
fibroblasts 2
lymphocytes 2
macrophages 1
CCL20 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 345 100.00 Very High Very High Very High
Inflammation 267 100.00 Very High Very High Very High
cytokine 83 100.00 Very High Very High Very High
Chronic pancreatitis 897 99.68 Very High Very High Very High
spastic colon 3 99.04 Very High Very High Very High
alcohol 39 98.96 Very High Very High Very High
Crohn's disease 9 96.64 Very High Very High Very High
pulpitis 8 95.80 Very High Very High Very High
fibrosis 81 94.56 High High
rheumatoid arthritis 62 93.56 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 2419 100.00 Very High Very High Very High
INFLAMMATION 305 100.00 Very High Very High Very High
Pancreatitis 1014 99.68 Very High Very High Very High
Cystadenoma 819 99.68 Very High Very High Very High
Inflammatory Bowel Disease 39 99.60 Very High Very High Very High
Malignant Neoplastic Disease 450 99.36 Very High Very High Very High
Cancer 681 99.32 Very High Very High Very High
Skin Cancer 80 99.20 Very High Very High Very High
Alcohol Addiction 39 99.20 Very High Very High Very High
Functional Bowel Disorder 3 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that CCL20 was mainly expressed in microvascular endothelial cells and macrophages that accumulated in inflamed pulp tissues and that its specific receptor, CCR6, was expressed on infiltrated lymphocytes.
Gene_expression (expressed) of CCL20 in lymphocytes
1) Confidence 0.78 Published 2008 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 18582332 Disease Relevance 0.27 Pain Relevance 0.30
CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines.
Gene_expression (production) of CCL20 in dental pulp associated with cytokine
2) Confidence 0.78 Published 2008 Journal Oral Microbiol. Immunol. Section Title Doc Link 18582332 Disease Relevance 0.27 Pain Relevance 0.37
CONCLUSION: Our results indicate that CCL20 expression is induced by stimulation with caries-related bacteria that have invaded deeply into the dentinal tubules as well as by proinflammatory cytokines in the inflamed pulpal lesions.
Gene_expression (expression) of CCL20 in tubules
3) Confidence 0.78 Published 2008 Journal Oral Microbiol. Immunol. Section Body Doc Link 18582332 Disease Relevance 0 Pain Relevance 0
However, the mechanism of CCL20 expression remains unclear.
Gene_expression (expression) of CCL20
4) Confidence 0.78 Published 2008 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 18582332 Disease Relevance 0.24 Pain Relevance 0.28
In PCA the CCL20 protein expression showed a significant 3-fold up-regulation compared to the matched normal pancreatic tissues (P < 0.05) (Figure 2A).
Gene_expression (expression) of CCL20 protein associated with pancreatic cancer
5) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.77 Pain Relevance 0.43
In accordance with earlier studies [14] reporting a faint but distinct CCL20 transcript in northern blot analysis of normal human pancreatic tissues, we observed low CCL20 mRNA and protein expression levels in the normal pancreatic tissues analyzed.
Gene_expression (expression) of CCL20 mRNA
6) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.27 Pain Relevance 0.11
Interestingly, comparing several clinicopathological factors to CCL20 mRNA and protein expression levels we found a significant correlation with advanced T-category pointing to a role for CCL20 and CCR6 in progression of PCA.
Gene_expression (expression) of CCL20 mRNA associated with pancreatic cancer
7) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.40 Pain Relevance 0.17
In PCA tissues the CCL20 transcript was detected in moderate to high levels [14] and expression of the CCL20 protein was observed in cancer cells within the pancreatic tumor mass [16].
Gene_expression (expression) of CCL20 protein associated with cancer and pancreatic cancer
8) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.32 Pain Relevance 0.16
Our results provide evidence that CCL20 expression is correlated with advanced T-category representing advanced PCA.
Gene_expression (expression) of CCL20 associated with pancreatic cancer
9) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 2.40 Pain Relevance 0.51
In accordance with these studies, we have observed a significant up-regulation of CCL20 mRNA and protein expression in PCA.
Gene_expression (expression) of CCL20 mRNA associated with pancreatic cancer
10) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.35 Pain Relevance 0.16
Since the CCL20 expression profile in CP is entirely inconspicuous, a putative role of CCL20 and CCR6 in the process of progression from CP into PCA can be ruled out.
Gene_expression (expression) of CCL20 associated with pancreatic cancer and chronic pancreatitis
11) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 2.35 Pain Relevance 0.70
In CP and PA specimens, the CCL20 mRNA and protein expression was weak, comparable to matched normal tissues.
Gene_expression (expression) of CCL20 mRNA associated with cystadenoma and chronic pancreatitis
12) Confidence 0.78 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.92 Pain Relevance 0.53
We asked whether CCL20 expression is altered in IBD.
Spec (whether) Gene_expression (expression) of CCL20 associated with inflammatory bowel disease
13) Confidence 0.77 Published 2004 Journal J. Clin. Immunol. Section Abstract Doc Link 14997037 Disease Relevance 1.41 Pain Relevance 0.30
Increased expression of CCL20 in human inflammatory bowel disease.
Gene_expression (expression) of CCL20 in bowel associated with inflammation
14) Confidence 0.77 Published 2004 Journal J. Clin. Immunol. Section Title Doc Link 14997037 Disease Relevance 1.51 Pain Relevance 0.32
Moreover, CCL20 production from pulpal fibroblasts was increased by stimulation with inetrleukin-1beta and tumor necrosis factor-alpha.
Gene_expression (production) of CCL20 in fibroblasts
15) Confidence 0.68 Published 2008 Journal Oral Microbiol. Immunol. Section Body Doc Link 18582332 Disease Relevance 0 Pain Relevance 0
METHODS AND RESULTS: In this study, we investigated the expression of CCL20 in monocytes/macrophages, endothelial cells, and pulpal fibroblasts after stimulation with Streptococcus mutans, a representative of caries-related bacteria, or proinflammatory cytokines.
Spec (investigated) Gene_expression (expression) of CCL20 in fibroblasts
16) Confidence 0.68 Published 2008 Journal Oral Microbiol. Immunol. Section Body Doc Link 18582332 Disease Relevance 0 Pain Relevance 0
CCL20 protein was weakly expressed in normal pancreatic tissue and in PA and CP specimens.
Gene_expression (expressed) of CCL20 protein associated with cystadenoma and chronic pancreatitis
17) Confidence 0.68 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.75 Pain Relevance 0.42
Likewise, we observed an entirely inconspicuous CCL20 expression profile in PA, a pancreatic disease also suspected to precede the development of PCA.
Gene_expression (expression) of CCL20 associated with cystadenoma, pancreatic cancer and pancreatitis
18) Confidence 0.68 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 2.51 Pain Relevance 0.72
Using immunohistochemistry CP, PA and PCA specimens along with the corresponding normal tissues were evaluated for CCL20 expression (Figure 3).
Gene_expression (expression) of CCL20 associated with cystadenoma, pancreatic cancer and chronic pancreatitis
19) Confidence 0.68 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 2.05 Pain Relevance 0.55
Interestingly, comparing several clinicopathological factors to CCL20 mRNA and protein expression levels we found a significant correlation with advanced T-category pointing to a role for CCL20 and CCR6 in progression of PCA.
Gene_expression (progression) of CCL20 associated with pancreatic cancer
20) Confidence 0.67 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.32 Pain Relevance 0.17

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