INT116974

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 9.55
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL20) extracellular space (CCL20) extracellular region (CCL20)
cell-cell signaling (CCL20)
Anatomy Link Frequency
umbilical vein 2
fibroblasts 2
bowel 2
tubules 2
dental pulp 2
CCL20 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 100.00 Very High Very High Very High
Inflammation 74 99.60 Very High Very High Very High
Chronic pancreatitis 92 98.56 Very High Very High Very High
Crohn's disease 3 96.64 Very High Very High Very High
pulpitis 5 96.24 Very High Very High Very High
chemokine 41 90.16 High High
Inflammatory response 4 87.68 High High
spastic colon 1 85.40 High High
fibrosis 8 83.20 Quite High
alcohol 4 22.72 Low Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 249 100.00 Very High Very High Very High
Inflammatory Bowel Disease 13 99.60 Very High Very High Very High
Polyps 29 99.12 Very High Very High Very High
Cystadenoma 84 98.64 Very High Very High Very High
Pancreatitis 104 98.56 Very High Very High Very High
Disease 34 96.32 Very High Very High Very High
Pulpitis 5 96.24 Very High Very High Very High
Cancer 84 94.80 High High
INFLAMMATION 76 94.00 High High
Adenoma 36 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Our results indicate that CCL20 expression is induced by stimulation with caries-related bacteria that have invaded deeply into the dentinal tubules as well as by proinflammatory cytokines in the inflamed pulpal lesions.
Positive_regulation (induced) of Gene_expression (expression) of CCL20 in tubules
1) Confidence 0.70 Published 2008 Journal Oral Microbiol. Immunol. Section Body Doc Link 18582332 Disease Relevance 0 Pain Relevance 0
CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines.
Positive_regulation (induced) of Gene_expression (production) of CCL20 in dental pulp associated with cytokine
2) Confidence 0.70 Published 2008 Journal Oral Microbiol. Immunol. Section Title Doc Link 18582332 Disease Relevance 0.27 Pain Relevance 0.37
Increased expression of CCL20 in human inflammatory bowel disease.
Positive_regulation (Increased) of Gene_expression (expression) of CCL20 in bowel associated with inflammation
3) Confidence 0.69 Published 2004 Journal J. Clin. Immunol. Section Title Doc Link 14997037 Disease Relevance 1.51 Pain Relevance 0.32
Interestingly, comparing several clinicopathological factors to CCL20 mRNA and protein expression levels we found a significant correlation with advanced T-category pointing to a role for CCL20 and CCR6 in progression of PCA.
Positive_regulation (pointing) of Gene_expression (progression) of CCL20 associated with pancreatic cancer
4) Confidence 0.50 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.33 Pain Relevance 0.17
By enzyme-linked immunosorbent assay, S. mutans induced a human monocytic cell line, differentiated macrophage-like THP-1 cells, and human umbilical vein endothelial cells (HUVEC) to produce an increased amount of CCL20.
Positive_regulation (increased) of Gene_expression (produce) of CCL20 in umbilical vein
5) Confidence 0.47 Published 2008 Journal Oral Microbiol. Immunol. Section Body Doc Link 18582332 Disease Relevance 0 Pain Relevance 0
Moreover, CCL20 production from pulpal fibroblasts was increased by stimulation with inetrleukin-1beta and tumor necrosis factor-alpha.
Positive_regulation (increased) of Gene_expression (production) of CCL20 in fibroblasts
6) Confidence 0.44 Published 2008 Journal Oral Microbiol. Immunol. Section Body Doc Link 18582332 Disease Relevance 0 Pain Relevance 0
It has been demonstrated by others that stimulation of CCR6 bearing PCA cells with CCL20 led to increased proliferation, migration and invasion [14-16].
Positive_regulation (stimulation) of Gene_expression (bearing) of CCL20 associated with pancreatic cancer
7) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.49 Pain Relevance 0.15
Using immunohistochemistry CP, PA and PCA specimens along with the corresponding normal tissues were evaluated for CCL20 expression (Figure 3).
Positive_regulation (evaluated) of Gene_expression (expression) of CCL20 associated with cystadenoma, pancreatic cancer and chronic pancreatitis
8) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 2.06 Pain Relevance 0.55
Lipoteichoic acid from S. mutans also elicited CCL20 production by HUVEC.
Positive_regulation (elicited) of Gene_expression (production) of CCL20
9) Confidence 0.41 Published 2008 Journal Oral Microbiol. Immunol. Section Body Doc Link 18582332 Disease Relevance 0 Pain Relevance 0
T-Category dependent CCL20 expression in PCA
Positive_regulation (dependent) of Gene_expression (expression) of CCL20 associated with pancreatic cancer
10) Confidence 0.41 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.60 Pain Relevance 0.31
In addition, IL-8, CXCL1, CXCL2, CXCL3, and CCL20 had higher levels of expression in the polyps compared to normal, which is in keeping with the current study.
Positive_regulation (levels) of Gene_expression (had) of CCL20 associated with polyps
11) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.29 Pain Relevance 0.26

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