INT116978

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2011
Negated 4
Speculated 3
Reported most in Body
Documents 53
Total Number 57
Disease Relevance 56.00
Pain Relevance 17.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCR6) plasma membrane (CCR6) signal transducer activity (CCR6)
Anatomy Link Frequency
T cell 8
B cells 5
Blood 3
lymphocytes 3
CD86 2
CCR6 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 830 100.00 Very High Very High Very High
rheumatoid arthritis 736 99.84 Very High Very High Very High
Inflammation 826 99.52 Very High Very High Very High
cytokine 176 99.50 Very High Very High Very High
fibrosis 41 99.00 Very High Very High Very High
spastic colon 3 98.64 Very High Very High Very High
Arthritis 431 98.40 Very High Very High Very High
Chronic pancreatitis 455 98.28 Very High Very High Very High
Osteoarthritis 153 96.68 Very High Very High Very High
Inflammatory response 27 93.08 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 988 99.90 Very High Very High Very High
Rheumatoid Arthritis 1130 99.84 Very High Very High Very High
Cancer 789 99.72 Very High Very High Very High
Disease 479 99.64 Very High Very High Very High
Systemic Lupus Erythematosus 298 99.58 Very High Very High Very High
INFLAMMATION 847 99.52 Very High Very High Very High
Malignant Neoplastic Disease 182 99.36 Very High Very High Very High
Adenocarcinoma 1022 99.24 Very High Very High Very High
Skin Cancer 58 99.20 Very High Very High Very High
Pancreatitis 500 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, CCR6 expression was also observed in the infiltrating lymphocytes.
Gene_expression (expression) of CCR6 in lymphocytes
1) Confidence 0.78 Published 2005 Journal J Endod Section Abstract Doc Link 15671814 Disease Relevance 0.38 Pain Relevance 0.32
In contrast, MIP-3alpha and CCR6 were rarely detected in normal pulp.
Gene_expression (detected) of CCR6
2) Confidence 0.78 Published 2005 Journal J Endod Section Abstract Doc Link 15671814 Disease Relevance 0.37 Pain Relevance 0.31
Macrophage inflammatory protein-3alpha (MIP-3alpha), a CC chemokine attracts CC chemokine receptor 6 (CCR6)-expressing T cells.
Gene_expression (expressing) of CCR6 in T cells associated with chemokine and inflammation
3) Confidence 0.78 Published 2005 Journal J Endod Section Abstract Doc Link 15671814 Disease Relevance 0.44 Pain Relevance 0.35
Macrophage inflammatory protein-3alpha (MIP-3alpha), a CC chemokine attracts CC chemokine receptor 6 (CCR6)-expressing T cells.
Gene_expression (expressing) of chemokine receptor 6 in T cells associated with chemokine and inflammation
4) Confidence 0.78 Published 2005 Journal J Endod Section Abstract Doc Link 15671814 Disease Relevance 0.44 Pain Relevance 0.35
Recent data show that T cells expressing CCR6, CXCR3, and CXCR6 act coordinately with respective ligands and Th1 inflammatory cytokines in the alveolitic/granuloma phases of the disease [41].
Gene_expression (expressing) of CCR6 in T cells associated with inflammation, disease, granuloma and cytokine
5) Confidence 0.75 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2559831 Disease Relevance 1.56 Pain Relevance 0.40
As assessed by western blot analysis CCR6 protein expression was detectable in all pancreatic disease entities under investigation, namely in CP, PA and PCA tisssue specimens as shown for representative patients in Figure 2B.
Gene_expression (expression) of CCR6 protein associated with cystadenoma, pancreatic cancer, pancreatitis and chronic pancreatitis
6) Confidence 0.72 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.98 Pain Relevance 0.47
Up-regulation of CCR6 expression has been observed in various cancer entities [19,20,22,35].
Gene_expression (expression) of CCR6 associated with cancer
7) Confidence 0.72 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 2.62 Pain Relevance 0.71
However, also in inflammatory diseases up-regulation of CCR6 expression has been reported [36-38].
Gene_expression (expression) of CCR6 associated with inflammation and disease
8) Confidence 0.72 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 2.60 Pain Relevance 0.69
These findings suggest that MIP-3alpha plays a role in the advancement of pulpal inflammation via the recruitment of CCR6-expressing lymphocytes.
Gene_expression (expressing) of CCR6-expressing in lymphocytes associated with inflammation
9) Confidence 0.68 Published 2005 Journal J Endod Section Abstract Doc Link 15671814 Disease Relevance 0.44 Pain Relevance 0.30
Interestingly, comparing several clinicopathological factors to CCL20 mRNA and protein expression levels we found a significant correlation with advanced T-category pointing to a role for CCL20 and CCR6 in progression of PCA.
Gene_expression (progression) of CCR6 associated with pancreatic cancer
10) Confidence 0.63 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.32 Pain Relevance 0.17
CCL20 and CCR6 mRNA expression was measured by Taqman-PCR, and protein secretion from colonic explant cultures (CEC) and its regulation by TNF-alpha by ELISA.
Gene_expression (expression) of CCR6
11) Confidence 0.61 Published 2004 Journal J. Clin. Immunol. Section Abstract Doc Link 14997037 Disease Relevance 1.45 Pain Relevance 0.30
In order to evaluate the potential contribution of CCL20/CCR6 in development and progression of PCA, we analyzed the mRNA and protein expression profiles of the CCL20/CCR6 system in patients with PCA as well as in patients with PA and CP, which represent pre-malignant diseases which often precede the formation of pancreatic malignancies [27,28].
Spec (analyzed) Gene_expression (expression) of CCR6 associated with malignant neoplastic disease, cystadenoma, pancreatic cancer, disease and chronic pancreatitis
12) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.62 Pain Relevance 0.23
Clinical validation of CCR6 expression showed no significant association with any of the clinicopathological factors tested.
Gene_expression (expression) of CCR6
13) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.63 Pain Relevance 0.29
Moreover, expression of the CCL20/CCR6 system has been reported in PCA tissues and pancreatic cancer cell lines.
Gene_expression (expression) of CCR6 associated with pancreatic cancer
14) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.81 Pain Relevance 0.29
In PCA, co-expression of CCL20 and CCR6 was reported in PCA tissues and in cultured human PCA cell lines.
Gene_expression (expression) of CCR6 associated with pancreatic cancer
15) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.41 Pain Relevance 0.16
CCL20/CCR6 protein expression in benign, pre-malignant and malignant pancreatic tissues
Gene_expression (expression) of CCR6 protein associated with malignant neoplastic disease
16) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.52 Pain Relevance 0.36
Only the G-protein coupled 7-transmembrane receptor CCR6, which is also expressed in human dendritic cells, shows a strong interaction with CCL20 [18].
Gene_expression (expressed) of CCR6 in dendritic cells
17) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.81 Pain Relevance 0.30
CCL20/CCR6 expression profile in pancreatic cancer

Background

Gene_expression (expression) of CCR6 associated with pancreatic cancer
18) Confidence 0.56 Published 2010 Journal J Transl Med Section Title Doc Link PMC2877001 Disease Relevance 1.03 Pain Relevance 0.22
CCL20/CCR6 mRNA and protein expressions in PCA were compared to several clinicopathological factors such as TNM stages, age, lymphatic and vascular invasion or pre-existing conditions like cirrhosis or fibrosis.
Gene_expression (expressions) of CCR6 mRNA associated with fibrosis, cirrhosis and pancreatic cancer
19) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.61 Pain Relevance 0.31
Using RealTime-PCR, enzyme-linked immunosorbent assay (ELISA), Western Blot and immunohistochemistry, we have analyzed the expression profile of CCL20/CCR6 in resection specimens from patients with chronic pancreatitis (CP) (n = 22), pancreatic cystadenoma (PA) (n = 11) and pancreatic carcinoma (PCA) (n = 25) as well as in the respective matched normal pancreatic tissues.


Spec (analyzed) Gene_expression (expression) of CCR6 associated with cystadenoma, pancreatic cancer and chronic pancreatitis
20) Confidence 0.56 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2877001 Disease Relevance 1.17 Pain Relevance 0.27

General Comments

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