INT116980

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.80
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL20) extracellular space (CCL20) extracellular region (CCL20)
cell-cell signaling (CCL20)
Anatomy Link Frequency
macrophage 1
umbilical vein 1
Bowel 1
CCL20 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 3 99.48 Very High Very High Very High
Chronic pancreatitis 23 99.22 Very High Very High Very High
alcohol 1 96.20 Very High Very High Very High
spastic colon 1 89.08 High High
Inflammation 9 75.52 Quite High
cytokine 8 50.00 Quite Low
Inflammatory response 1 9.40 Low Low
chemokine 11 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rectal Cancer 10 100.00 Very High Very High Very High
Disease 21 99.48 Very High Very High Very High
Pancreatitis 26 99.22 Very High Very High Very High
Inflammatory Bowel Disease 13 99.20 Very High Very High Very High
Colitis 2 98.32 Very High Very High Very High
Pancreatic Cancer 74 97.88 Very High Very High Very High
Alcohol Addiction 1 96.44 Very High Very High Very High
Obesity 1 95.72 Very High Very High Very High
Nicotine Addiction 1 95.36 Very High Very High Very High
Cancer 68 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By enzyme-linked immunosorbent assay, S. mutans induced a human monocytic cell line, differentiated macrophage-like THP-1 cells, and human umbilical vein endothelial cells (HUVEC) to produce an increased amount of CCL20.
Positive_regulation (increased) of CCL20 in umbilical vein
1) Confidence 0.70 Published 2008 Journal Oral Microbiol. Immunol. Section Body Doc Link 18582332 Disease Relevance 0 Pain Relevance 0
CCL20 mRNA and protein were severalfold increased in involved CD and UC but not in non-IBD colitis.
Neg (not) Positive_regulation (increased) of CCL20 associated with colitis, inflammatory bowel disease and crohn's disease
2) Confidence 0.69 Published 2004 Journal J. Clin. Immunol. Section Abstract Doc Link 14997037 Disease Relevance 1.53 Pain Relevance 0.29
RESULTS: In the microarray analysis of hip drain neutrophils, interleukin-1 receptor antagonist (IL1RN), interleukin-18 receptor 1 (IL18R1), macrophage migration inhibitory factor (MIF), and macrophage inflammatory protein 3alpha (CCL20) were upregulated, whereas interleukin-8 receptor beta (IL8RB/CXCR2) was consistently downregulated, compared with presurgery blood neutrophils.
Positive_regulation (upregulated) of CCL20 in macrophage
3) Confidence 0.58 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690273 Disease Relevance 0.07 Pain Relevance 0
Since the CCL20 expression profile in CP is entirely inconspicuous, a putative role of CCL20 and CCR6 in the process of progression from CP into PCA can be ruled out.
Positive_regulation (role) of CCL20 associated with pancreatic cancer and chronic pancreatitis
4) Confidence 0.50 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 2.41 Pain Relevance 0.73
Three randomized phase III studies, STAR-01 (primary objective: overall survival), ACCORD 12/0405 PRODIGE 2 (primary objective: pathological complete response) and National Surgical Adjuvant Breast and Bowel Project (NSABP) R-04, have been conducted to study the role of oxaliplatin in the neoadjuvant CRT for LARC.
Positive_regulation (neoadjuvant) of LARC in Bowel associated with rectal cancer
5) Confidence 0.16 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2856525 Disease Relevance 0.79 Pain Relevance 0

General Comments

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