INT11699

Context Info Confidence 0.47 First Reported 1990 Last Reported 2011 Negated 2 Speculated 2 Reported most in Body Documents 85 Total Number 88 Disease Relevance 52.51 Pain Relevance 13.41

plasma membrane (HLA-E)

Anatomy Link Frequency T cell 16 groove 2 skin 2 gut 1 Reiter 1 HLA-E (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 664 100.00 rheumatoid arthritis 647 100.00 spinal inflammation 346 100.00 cINOD 43 100.00 Multiple sclerosis 268 99.52 antagonist 31 99.48 Opioid 1 99.26 psoriasis 58 99.16 Arthritis 449 98.72 corticosteroid 23 97.72

Disease Link Frequency Relevance Heat Disease 1409 100.00 Rheumatoid Arthritis 670 100.00 INFLAMMATION 653 100.00 Staphylococcus Infection 418 100.00 Adverse Drug Reaction 395 100.00 Low Back Pain 338 100.00 Syndrome 222 100.00 Bullous Skin Disease 214 100.00 Hypopigmentation 32 100.00 Skin Infection 2 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The current concept of an extraarticular bacterial infection functioning as the triggering event in a genetically susceptible host suggests the possibility of direct microbial-MHC interaction.

MHC Binding (interaction) of associated with bacterial infection

1) Confidence 0.47 Published 1992 Journal J. Immunol. Section Abstract Doc Link 1588045 Disease Relevance 0.46 Pain Relevance 0.14

Transgenic mice present a unique opportunity to study the association of specific MHC genes and disease.

MHC Binding (association) of associated with targeted disruption and disease

2) Confidence 0.47 Published 1990 Journal Ann. Rheum. Dis. Section Abstract Doc Link 2115764 Disease Relevance 1.86 Pain Relevance 0.34

Immunogenetic parameters play a role for the manifestations of the pathologic immune response both in the gut and in the musculo-skeletal systems, as indicated by associations with MHC class I alleles.

MHC Binding (associations) of in gut

3) Confidence 0.47 Published 2002 Journal Z Gastroenterol Section Abstract Doc Link 11930300 Disease Relevance 0.81 Pain Relevance 0.18

Whole-genome scans showed that some affected-sibling-pair families with AS not only demonstrated strong linkage to the MHC locus, but also identified other regions with suggestive or stronger linkage on chromosomes 1p, 2q, 9q, 10q, 16q and 19q.

MHC Binding (linkage) of associated with spinal inflammation

4) Confidence 0.47 Published 2004 Journal Yi Chuan Xue Bao Section Abstract Doc Link 15195556 Disease Relevance 0.78 Pain Relevance 0.69

From a sexual selection perspective, our finding that nonMHC-d2 was associated with health provides some of the first evidence that genetic diversity outside the MHC is beneficial for the individual.

nonMHC Binding (associated) of

5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0 Pain Relevance 0

Although many studies have reported associations between AS and other genes in the major histocompatibility complex (MHC) in AS, no conclusive results have emerged.

MHC Binding (associations) of associated with spinal inflammation

6) Confidence 0.37 Published 2007 Journal Genes Immun. Section Abstract Doc Link 17167495 Disease Relevance 0.64 Pain Relevance 0.71

In addition, there was also a small independent effect of MHC-d2 on health after controlling for the effect of nonMHC-d2, with individuals with greater MHC-d2 reporting fewer symptoms.

MHC-d2 Binding (individuals) of

7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.08 Pain Relevance 0

In addition, there was also a small independent effect of MHC-d2 on health after controlling for the effect of nonMHC-d2, with individuals with greater MHC-d2 reporting fewer symptoms.

MHC-d2 Binding (individuals) of

8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.07 Pain Relevance 0

Of the 5 identified associations between HLA-E and HLA-Cw/B, the most significant were (E*0101, Cw*0701, B*0801) and (E*010302, Cw*0702, B*0702).

HLA-E Binding (associations) of

9) Confidence 0.36 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

HLA-E haplotype assignment

HLA-E Binding (assignment) of

10) Confidence 0.36 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0.05 Pain Relevance 0

HLA-E alleles were found to be in significant association with 10 CEHs (Table 3), but excluding HLA-A reduced this number.

HLA-E Binding (association) of

11) Confidence 0.36 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

LD for alleles at loci between HLA-E and HLA-A or between HLA-C and HLA-B was analyzed in Panel 2 using delta (?)

HLA-E Binding (loci) of

12) Confidence 0.36 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

HLA-E typing

HLA-E Binding (typing) of

13) Confidence 0.36 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

However, MHC proteins can also be linked to autoimmune diseases, and the HLA-B27 allele is expressed by 95% of people with the rheumatic condition ankylosing spondylitis (AS).

MHC Binding (linked) of associated with spinal inflammation and autoimmune disease

14) Confidence 0.36 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16677075 Disease Relevance 0.37 Pain Relevance 0.27

The exact mechanism and role of MHCI in the visual cortex is yet to be elucidated, although previous studies have shown that MHCI may associate with PI-3, which is known to be a synaptogenic molecule [8,87].

MHC Binding (associate) of in cortex

15) Confidence 0.36 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0.05

Similarities between AS and ANKENT include not only affected tissue (joint entheses) but also association of the disease with genetic background, including MHC genes, gender, and age.

MHC Binding (association) of in joint associated with spinal inflammation and disease

16) Confidence 0.36 Published 2000 Journal Hum. Immunol. Section Abstract Doc Link 10825583 Disease Relevance 0.81 Pain Relevance 0.29

The MHC microsatellites used here are known to be in linkage with MHC Class I, II, and III genes [67].

MHC Binding (linkage) of

17) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0 Pain Relevance 0

Although we measured genetic diversity using microsatellites assumed to be selectively neutral, the MHC markers used here are known to be in linkage with MHC genes [67].

MHC Binding (linkage) of

18) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0 Pain Relevance 0

2 and LD analysis, non-random association of HLA-E alleles with alleles at other class I loci and the HLA-E allele markers for 10 CEHs.

HLA-E Binding (association) of

19) Confidence 0.35 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

It is thought that in this "free heavy chain" form, MHCI molecules may interact in cis with certain receptors and thereby regulate their trafficking [6-8].

MHC Binding (interact) of

20) Confidence 0.35 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0

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