INT11699
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The current concept of an extraarticular bacterial infection functioning as the triggering event in a genetically susceptible host suggests the possibility of direct microbial-MHC interaction. | |||||||||||||||
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Transgenic mice present a unique opportunity to study the association of specific MHC genes and disease. | |||||||||||||||
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Immunogenetic parameters play a role for the manifestations of the pathologic immune response both in the gut and in the musculo-skeletal systems, as indicated by associations with MHC class I alleles. | |||||||||||||||
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Whole-genome scans showed that some affected-sibling-pair families with AS not only demonstrated strong linkage to the MHC locus, but also identified other regions with suggestive or stronger linkage on chromosomes 1p, 2q, 9q, 10q, 16q and 19q. | |||||||||||||||
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From a sexual selection perspective, our finding that nonMHC-d2 was associated with health provides some of the first evidence that genetic diversity outside the MHC is beneficial for the individual. | |||||||||||||||
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Although many studies have reported associations between AS and other genes in the major histocompatibility complex (MHC) in AS, no conclusive results have emerged. | |||||||||||||||
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In addition, there was also a small independent effect of MHC-d2 on health after controlling for the effect of nonMHC-d2, with individuals with greater MHC-d2 reporting fewer symptoms. | |||||||||||||||
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In addition, there was also a small independent effect of MHC-d2 on health after controlling for the effect of nonMHC-d2, with individuals with greater MHC-d2 reporting fewer symptoms. | |||||||||||||||
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Of the 5 identified associations between HLA-E and HLA-Cw/B, the most significant were (E*0101, Cw*0701, B*0801) and (E*010302, Cw*0702, B*0702). | |||||||||||||||
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HLA-E haplotype assignment | |||||||||||||||
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HLA-E alleles were found to be in significant association with 10 CEHs (Table 3), but excluding HLA-A reduced this number. | |||||||||||||||
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LD for alleles at loci between HLA-E and HLA-A or between HLA-C and HLA-B was analyzed in Panel 2 using delta (?) | |||||||||||||||
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HLA-E typing | |||||||||||||||
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However, MHC proteins can also be linked to autoimmune diseases, and the HLA-B27 allele is expressed by 95% of people with the rheumatic condition ankylosing spondylitis (AS). | |||||||||||||||
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The exact mechanism and role of MHCI in the visual cortex is yet to be elucidated, although previous studies have shown that MHCI may associate with PI-3, which is known to be a synaptogenic molecule [8,87]. | |||||||||||||||
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Similarities between AS and ANKENT include not only affected tissue (joint entheses) but also association of the disease with genetic background, including MHC genes, gender, and age. | |||||||||||||||
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The MHC microsatellites used here are known to be in linkage with MHC Class I, II, and III genes [67]. | |||||||||||||||
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Although we measured genetic diversity using microsatellites assumed to be selectively neutral, the MHC markers used here are known to be in linkage with MHC genes [67]. | |||||||||||||||
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2 and LD analysis, non-random association of HLA-E alleles with alleles at other class I loci and the HLA-E allele markers for 10 CEHs. | |||||||||||||||
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It is thought that in this "free heavy chain" form, MHCI molecules may interact in cis with certain receptors and thereby regulate their trafficking [6-8]. | |||||||||||||||
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General Comments
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