INT116996

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 7.51
Pain Relevance 8.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp)
Anatomy Link Frequency
brain 2
spine 1
muscle 1
pelvis 1
endothelium 1
Pgp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 174 100.00 Very High Very High Very High
IPN 18 99.98 Very High Very High Very High
Inflammatory mediators 3 99.84 Very High Very High Very High
Acupuncture 246 99.64 Very High Very High Very High
Central nervous system 12 98.96 Very High Very High Very High
analgesia 15 98.36 Very High Very High Very High
Morphine 15 97.96 Very High Very High Very High
Inflammation 16 97.16 Very High Very High Very High
antinociception 3 96.60 Very High Very High Very High
iatrogenic 2 94.44 High High
Disease Link Frequency Relevance Heat
Pain 177 100.00 Very High Very High Very High
Epilepsy 3 100.00 Very High Very High Very High
Brain Disease 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Inflammatory Pain 18 99.98 Very High Very High Very High
INFLAMMATION 19 99.84 Very High Very High Very High
Hyperlipidemia 56 99.02 Very High Very High Very High
Disease 12 96.64 Very High Very High Very High
Syndrome 7 93.84 High High
Hyperalgesia 7 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This concept has been used with our pump system to allow careful evaluation of how drugs are affecting the PgP-system at the blood-brain-barrier [13,14].
Regulation (affecting) of PgP in brain
1) Confidence 0.51 Published 2008 Journal BMC Med Phys Section Body Doc Link PMC2430701 Disease Relevance 0 Pain Relevance 0.06
There was no effect of the Pgp inhibitors on net absorption for any of the local anaesthetics in the two absorption models.
Neg (no) Regulation (effect) of Pgp
2) Confidence 0.45 Published 2004 Journal Eur J Pharm Sci Section Abstract Doc Link 14998587 Disease Relevance 0 Pain Relevance 0.27
In the present study, we examined the effects of lambda-carrageenan-induced inflammatory pain (CIP) on brain endothelium regulation of Pgp.
Regulation (regulation) of Pgp in endothelium associated with ipn
3) Confidence 0.37 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.23 Pain Relevance 1.44
Moreover, Pgp is known to confer multi-drug resistance in cancer chemotherapy and brain diseases, such as epilepsy, and is highly regulated by inflammatory mediators.
Regulation (regulated) of Pgp in brain associated with epilepsy, inflammatory mediators, brain disease and cancer
4) Confidence 0.37 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.04 Pain Relevance 0.79
Women affected with PGP typically adopt abnormal patterns of muscle activity, to relieve and avoid pain.
Regulation (affected) of PGP in muscle associated with pain
5) Confidence 0.29 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2467402 Disease Relevance 1.80 Pain Relevance 1.64
The effect of increased level of free fatty acid on Pgp and its regulation of stereoid transport to central nervous system are not known.
Regulation (regulation) of Pgp in central nervous system associated with central nervous system
6) Confidence 0.28 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.47 Pain Relevance 0.24
The observation that CIP modulates Pgp at the BBB in vivo is critical to understanding BBB regulation during inflammatory disease states.
Regulation (modulates) of Pgp associated with inflammation, ipn and disease
7) Confidence 0.27 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.30 Pain Relevance 1.65
It is possible that the hyperlipidemia observed in the HF-HD and HF-LD rats might have altered the steroid-proteins [CBG & Pgp] interactions which in turn might have altered the availability of Dex.
Spec (might) Regulation (altered) of Pgp associated with hyperlipidemia
8) Confidence 0.18 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.51 Pain Relevance 0.20
The aim with acupuncture was to establish control of PGP to prevent dysfunction of muscles of the spine and pelvis.
Regulation (control) of PGP in pelvis associated with pain and acupuncture
9) Confidence 0.17 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2467402 Disease Relevance 0.55 Pain Relevance 0.86
Taken collectively, our findings indicate that TSB is a substrate for PgP and MRP1 and that drug resistance to TSB therapy and drug interactions may occur through PgP and MRP1 modulation.
Regulation (modulation) of PgP
10) Confidence 0.14 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0 Pain Relevance 0
The aim with acupuncture was to establish control of PGP to prevent dysfunction of muscles of the spine and pelvis.
Regulation (control) of PGP in spine associated with pain and acupuncture
11) Confidence 0.06 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2467402 Disease Relevance 0.55 Pain Relevance 0.86
Immunoreactivity for PGP 9.5 or TRPV1 was detected in papillary structures as well as within the epithelium (free intra-epithelial endings).
Regulation (Immunoreactivity) of PGP in epithelium
12) Confidence 0.03 Published 2006 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 16462539 Disease Relevance 0.06 Pain Relevance 0

General Comments

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