INT11700

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.61
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 5 97.20 Very High Very High Very High
Arthritis 6 67.00 Quite High
methadone 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 23 100.00 Very High Very High Very High
Disease 5 100.00 Very High Very High Very High
Infection 2 99.86 Very High Very High Very High
Coronary Artery Disease 4 96.80 Very High Very High Very High
Renal Disease 2 96.32 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 91.84 High High
Targeted Disruption 1 90.24 High High
Myocardial Infarction 11 87.76 High High
Syndrome 4 83.12 Quite High
Hypersensitivity 16 82.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, it appears that arthritogenic infections might downregulate HLA-B27 expression, favoring bacterial survival.
Spec (might) Negative_regulation (downregulate) of Gene_expression (expression) of HLA-B27 associated with infection
1) Confidence 0.50 Published 2000 Journal Curr Opin Rheumatol Section Abstract Doc Link 10910175 Disease Relevance 0.26 Pain Relevance 0.07
The decreased invasion in the HLA-B27 transfectants is not the result of either altered endogenous mouse class I expression as a result of human class I transfection or increased intracellular bacterial killing within the B27 transfectants.
Negative_regulation (decreased) of Gene_expression (transfectants) of HLA-B27
2) Confidence 0.29 Published 1992 Journal J. Immunol. Section Abstract Doc Link 1588045 Disease Relevance 0.40 Pain Relevance 0.12
HLA B27 in health and disease: a double-edged sword?
Negative_regulation (double-edged) of Gene_expression (disease) of HLA B27 associated with seronegative spondarthritis and disease
3) Confidence 0.19 Published 2002 Journal Rheumatology (Oxford) Section Title Doc Link 12154202 Disease Relevance 1.41 Pain Relevance 0.41
In patients without these risk factors and a negative HLA-B5701 screen, the abacavir/lamivudine combination is a suitable alternative especially in patients with renal disease and contraindications to tenofovir.



Negative_regulation (negative) of Gene_expression (screen) of HLA-B5701 associated with renal disease
4) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.54 Pain Relevance 0

General Comments

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