INT117004

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 15.95
Pain Relevance 5.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Sfpi1) nucleus (Sfpi1) DNA binding (Sfpi1)
Anatomy Link Frequency
fibroblasts 2
covering 1
brain 1
BT-474 1
leukocytes 1
Sfpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 640 100.00 Very High Very High Very High
qutenza 10 99.68 Very High Very High Very High
Inflammatory response 208 98.84 Very High Very High Very High
opioid receptor 36 97.36 Very High Very High Very High
fibrosis 81 90.48 High High
Opioid 6 88.08 High High
chemokine 108 84.72 Quite High
mu opioid receptor 3 75.00 Quite High
Potency 4 67.28 Quite High
imagery 43 56.88 Quite High
Disease Link Frequency Relevance Heat
Injury 1314 100.00 Very High Very High Very High
INFLAMMATION 849 100.00 Very High Very High Very High
Congenital Anomalies 25 100.00 Very High Very High Very High
Targeted Disruption 76 99.96 Very High Very High Very High
Leukemia 210 99.88 Very High Very High Very High
Cancer 106 99.22 Very High Very High Very High
Myocardial Infarction 8 98.48 Very High Very High Very High
Fibrosis 98 96.96 Very High Very High Very High
Hypereosinophilic Syndrome 27 94.24 High High
Eczema 18 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PU.1 is a member of the ets family of transcription factors, expressed predominantly in hematopoietic cells and microglia of brain.
Gene_expression (expressed) of PU.1 in brain
1) Confidence 0.75 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0 Pain Relevance 0.49
For instance, it has been shown that reprogramming of fibroblasts into macrophage-like cells remains unstable, resulting in the loss of macrophage markers, following silencing of retrovirally expressed PU.1 and C/EBP?
Gene_expression (expressed) of PU.1 in fibroblasts
2) Confidence 0.75 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.18 Pain Relevance 0.03
PU.1 expression level determines the fate of the cell and is necessary for dictating monocyte/macrophage and dendritic cell commitment and differentiation, as well as for neutrophil differentiation.
Gene_expression (expression) of PU.1 in neutrophil
3) Confidence 0.75 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.08 Pain Relevance 0
Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kr├╝ppel-like factor 1 (KLF1) in the BFU-E colonies.
Gene_expression (expression) of PU.1 in BFU-E associated with qutenza
4) Confidence 0.75 Published 2007 Journal Exp. Mol. Med. Section Abstract Doc Link 17603282 Disease Relevance 0.16 Pain Relevance 0.75
Human blood monocytes, which constitutively express Spi-l/PU.1, are exquisitely sensitive to LPS inducible IL-1?
Gene_expression (express) of PU.1 in monocytes
5) Confidence 0.75 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2529264 Disease Relevance 0.28 Pain Relevance 0.05
These complex abnormalities were observed in neutron-irradiated ML-like mice; however, no pathological features of differentiated ML mice expressing complex abnormalities were identified from those expressing the simple loss of one copy of PU.1.
Gene_expression (expressing) of PU.1 associated with leukemia and congenital anomalies
6) Confidence 0.67 Published 2008 Journal Mol Cytogenet Section Body Doc Link PMC2572613 Disease Relevance 0.67 Pain Relevance 0
FISH probes covering PU.1 and the centromere of chromosome 2 were labeled directly with Spectrum Green and Spectrum Orange (Vysis, Downers Grove, IL, USA), respectively [14].
Gene_expression (labeled) of PU.1 in covering
7) Confidence 0.67 Published 2008 Journal Mol Cytogenet Section Body Doc Link PMC2572613 Disease Relevance 0.13 Pain Relevance 0
For instance, it has been shown that reprogramming of fibroblasts into macrophage-like cells remains unstable, resulting in the loss of macrophage markers, following silencing of retrovirally expressed PU.1 and C/EBP?
Gene_expression (expressed) of PU.1 in fibroblasts
8) Confidence 0.65 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.18 Pain Relevance 0.03
When the PU.1 gene is disrupted as in PU.1 knock-out mice and using small interfering RNA-based strategy in RAW264.7 cells, the transcription of the endogenous target MOR gene is increased significantly.
Gene_expression (disrupted) of PU.1 associated with targeted disruption and opioid receptor
9) Confidence 0.65 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0.25 Pain Relevance 0.64
When the PU.1 gene is disrupted as in PU.1 knock-out mice and using small interfering RNA-based strategy in RAW264.7 cells, the transcription of the endogenous target MOR gene is increased significantly.
Gene_expression (disrupted) of PU.1 associated with targeted disruption and opioid receptor
10) Confidence 0.65 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0.24 Pain Relevance 0.64
This suggests that Onzin might be expressed in wild-type skin by resident inflammatory cells and in the PU.1 null wound, either by inflammatory cells whose development is delayed, such as T cells, or that there may be an alternative or compensatory mechanism of gene regulation in non-inflammatory cells at the wound site.
Gene_expression (expressed) of PU.1 in skin associated with inflammation and injury
11) Confidence 0.60 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.42 Pain Relevance 0.32
The heatmaps for early and late inflammatory gene clusters strikingly reveal robust expression in wild-type wounds, but little or no expression in the PU.1 null mice for these genes (Figure 6).
Neg (no) Gene_expression (expression) of PU.1 associated with inflammation and injury
12) Confidence 0.60 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.15 Pain Relevance 0.29
A further 17 genes are initially expressed at both the wild-type and PU.1 wound site, but are maintained at high level only in the wild-type wound, where there is an influx of leukocytes.
Gene_expression (expressed) of PU.1 in leukocytes associated with injury
13) Confidence 0.60 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.50 Pain Relevance 0.40
Cathepsin S is a typical gene of the late inflammatory cluster, being highly upregulated at 24 hours post-wounding in the wild-type, but with no expression in the PU.1 null wound (Figure 7Ba).
Neg (no) Gene_expression (expression) of PU.1 associated with inflammation and injury
14) Confidence 0.60 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.00 Pain Relevance 0.29
Some neutron-irradiated mice had cells showing translocated PU.1, although no pathological features differentiated these ML mice from ML mice expressing the simple loss of PU.1.
Neg (no) Gene_expression (expressing) of PU.1 associated with leukemia
15) Confidence 0.60 Published 2008 Journal Mol Cytogenet Section Abstract Doc Link PMC2572613 Disease Relevance 1.31 Pain Relevance 0
Frequency of cells with 1 PU.1 signal and 2 centromere signals
Gene_expression (signal) of PU.1
16) Confidence 0.58 Published 2008 Journal Mol Cytogenet Section Body Doc Link PMC2572613 Disease Relevance 0.65 Pain Relevance 0
Frequency of PU.1 abnormalities in radiation-induced ML mice
Gene_expression (abnormalities) of PU.1 associated with leukemia and congenital anomalies
17) Confidence 0.58 Published 2008 Journal Mol Cytogenet Section Body Doc Link PMC2572613 Disease Relevance 0.97 Pain Relevance 0
A comparison of those genes expressed during the repair process in wild-type versus PU.1 null mice reveals most clearly genes that are dependent on the presence of an inflammatory response at the wound site.
Gene_expression (expressed) of PU.1 associated with inflammatory response and injury
18) Confidence 0.52 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.03 Pain Relevance 0.23
In PU.1 null wounds, where there is no such influx, these genes are only transiently expressed.
Gene_expression (expressed) of PU.1 associated with injury
19) Confidence 0.47 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.42 Pain Relevance 0.39
In situ hybridization studies reveal a rather similar expression pattern in both wild-type and PU.1 null wounds (Figure 7Ah,i).
Gene_expression (expression) of PU.1 associated with injury
20) Confidence 0.24 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.32 Pain Relevance 0.28

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