INT117014

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Context Info
Confidence 0.13
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 1.60
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TCN2) extracellular region (TCN2)
Anatomy Link Frequency
Brain 1
smooth muscle cells 1
Iris 1
TCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 24 99.44 Very High Very High Very High
chemokine 2 85.76 High High
Opioid 6 85.60 High High
Endogenous opioid 4 81.84 Quite High
bradykinin 10 80.80 Quite High
Inflammation 59 26.44 Quite Low
rheumatoid arthritis 18 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 5 100.00 Very High Very High Very High
Sepsis 14 99.42 Very High Very High Very High
Cognitive Disorder 31 95.96 Very High Very High Very High
Disease 95 94.04 High High
Critical Illness 13 87.60 High High
Adhesions 13 86.84 High High
Increased Venous Pressure Under Development 41 78.48 Quite High
American Trypanosomiasis 31 64.24 Quite High
Injury 21 59.28 Quite High
Diabetes Mellitus 37 58.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study included a very comprehensive analysis of historically published host records of T. cruzi lineages that clearly suggests the proposed association of the genus Didelphis with TCI, and armadillos with TCII [121].
TCII Binding (association) of
1) Confidence 0.13 Published 2009 Journal Veterinary Research Section Body Doc Link PMC2695024 Disease Relevance 0.06 Pain Relevance 0
The fitness for the Ageing Brain Study II (FABS II): protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer's disease

Background

FABS II Binding (fitness) of in Brain associated with cognitive disorder, aging and disease
2) Confidence 0.08 Published 2010 Journal Trials Section Title Doc Link PMC3016362 Disease Relevance 0.85 Pain Relevance 0
The stimulation was associated primarily with an increase in the affinity for deltorphin II.
deltorphin II Binding (affinity) of
3) Confidence 0.03 Published 2008 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 18762712 Disease Relevance 0 Pain Relevance 0.46
Large upfield displacement of alpha-proton chemical shifts was observed for Leu(295), Val(296), and Val(297) in hDOR-(279-299) following its interaction with deltorphin II, thus identifying a gain in beta-conformation at the receptor peptide C terminus.
deltorphin II Binding (interaction) of
4) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14999000 Disease Relevance 0 Pain Relevance 0.18
Binding of the delta-selective ligand deltorphin II to hDOR-(279-299) destabilized the helix at the receptor peptide N terminus.
deltorphin II Binding (Binding) of
5) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14999000 Disease Relevance 0 Pain Relevance 0.24
A hypothesis describing the conformational events accompanying selective deltorphin II binding to the delta-opioid receptor is presented.
deltorphin II Binding (binding) of associated with opioid receptor
6) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14999000 Disease Relevance 0 Pain Relevance 0.11
Exploring deltorphin II binding to the third extracellular loop of the delta-opioid receptor.
deltorphin II Binding (binding) of associated with opioid receptor
7) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 14999000 Disease Relevance 0 Pain Relevance 0.30
AT II binds to and regulates vascular smooth muscle cells tone via specific angiotensin receptors (Studdy et al 1983).
AT II Binding (binds) of in smooth muscle cells
8) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.39 Pain Relevance 0.08
Multivariate analysis of the subgroup of patients admitted without sepsis (n = 82) reveals that while APACHE II remained significantly associated with 28-day mortality (OR 1.2, 95% CI 1.03–1.28 per point increment), abnormal cTnI level was not (OR 1.2, 95% CI 0.21–7.1).


APACHE II Binding (associated) of associated with sepsis
9) Confidence 0.01 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.30 Pain Relevance 0
IRAC II and IxAC-B4 might accidentally bind to other components of the complement system such as C6, C7, C8 and C9 of the MAC, as they also possess repeats of the TSR (TSP1) motif characteristic of Properdin [14].
IRAC II Spec (might) Binding (bind) of
10) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
IRAC II and IxAC-B1 purified from the baculovirus/Sf9 expression system, but not unrelated protein Iris, strongly bound to properdin.
IRAC II Binding (bound) of in Iris
11) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
In a first series of experiments we tested the binding of purified recombinant IRAC II and IxAC-B1 and unrelated protein IRIS to C3 convertase components.
recombinant IRAC II Binding (binding) of
12) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0

General Comments

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