INT117024

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.56
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
motor nerve 2
nerve 2
medial 2
sympathetic 2
Acot1 (Mus musculus)
Pain Link Frequency Relevance Heat
noradrenaline 5 99.84 Very High Very High Very High
anesthesia 6 99.60 Very High Very High Very High
halothane 4 99.38 Very High Very High Very High
isoflurane 7 99.10 Very High Very High Very High
agonist 1 99.02 Very High Very High Very High
antagonist 4 92.92 High High
tetrodotoxin 4 91.60 High High
Neurotransmitter 2 91.52 High High
Potency 1 88.24 High High
Migraine 1 86.72 High High
Disease Link Frequency Relevance Heat
Paralysis 2 99.76 Very High Very High Very High
Syndrome 16 99.58 Very High Very High Very High
Spinocerebellar Ataxia Type 2 1 89.08 High High
Ataxia 1 87.40 High High
Migraine With Aura 1 86.72 High High
Wrinkles 2 75.36 Quite High
Neurological Disease 1 75.00 Quite High
Channelopathies 1 75.00 Quite High
Neuromuscular Disease 1 74.60 Quite High
Cerebral Palsy 2 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During naturally occurring states of sleep and wakefulness, but not anesthesia, ODQ caused a significant (P < 0.001) decrease in ACh release.
Negative_regulation (decrease) of Localization (release) of ACh associated with anesthesia
1) Confidence 0.41 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.41
Isoflurane and halothane anesthesia have been shown to decrease ACh release in the medial pontine reticular formation.
Negative_regulation (decrease) of Localization (release) of ACh in medial associated with anesthesia, halothane and isoflurane
2) Confidence 0.41 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16424074 Disease Relevance 0 Pain Relevance 0.47
The muscarinic agonist bethanechol dialyzed into the PnO significantly decreased ACh release by 60% compared with control.
Negative_regulation (decreased) of Localization (release) of ACh associated with agonist
3) Confidence 0.37 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207318 Disease Relevance 0 Pain Relevance 0.36
Release of ACh appears to be tonically inhibited by NA released from sympathetic nerve terminals through action at prejunctional alpha(2)-adrenoceptors.
Negative_regulation (inhibited) of Localization (Release) of ACh in sympathetic associated with noradrenaline
4) Confidence 0.24 Published 2009 Journal Neuroscience Section Abstract Doc Link 19486927 Disease Relevance 0 Pain Relevance 0.31
LEMS is characterized by decreased evoked quantal release of acetylcholine (ACh) and disruption of the presynaptic active zones, the sites at which ACh is thought to be released.
Negative_regulation (decreased) of Localization (release) of ACh associated with syndrome
5) Confidence 0.20 Published 2003 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 15000529 Disease Relevance 1.24 Pain Relevance 0.15
It then specifically cleaves SNAP-25, an essential protein in exocytosis, thus preventing the ‘quantal’ release of ACh in response to nerve impulses (Schiavo et al. 2000).
Negative_regulation (preventing) of Localization (release) of ACh in nerve
6) Confidence 0.09 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.22 Pain Relevance 0
Recovery of mouse neuromuscular junctions from single and repeated injections of botulinum neurotoxin A

Botulinum neurotoxin type A (BoNT/A) paralyses muscles by blocking acetylcholine (ACh) release from motor nerve terminals.

Negative_regulation (blocking) of Localization (release) of ACh in motor nerve associated with paralysis
7) Confidence 0.07 Published 2008 Journal The Journal of Physiology Section Title Doc Link PMC2538785 Disease Relevance 0.10 Pain Relevance 0

General Comments

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