INT117031

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Context Info
Confidence 0.21
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.82
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Samsn1) nucleus (Samsn1)
Anatomy Link Frequency
liver 3
Samsn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 31 98.62 Very High Very High Very High
fibrosis 200 88.88 High High
Paracetamol 2 75.80 Quite High
Bile 5 70.68 Quite High
Inflammation 22 69.92 Quite High
spastic colon 2 68.80 Quite High
tolerance 4 33.84 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 86 100.00 Very High Very High Very High
Fatty Liver 81 100.00 Very High Very High Very High
Hypoxia 50 99.82 Very High Very High Very High
Liver Disease 20 99.18 Very High Very High Very High
Obesity 29 99.04 Very High Very High Very High
Cirrhosis 56 96.64 Very High Very High Very High
Hepatic Insufficiency 2 95.48 Very High Very High Very High
Hepatotoxicity 4 95.12 Very High Very High Very High
Fibrosis 186 88.88 High High
Congenital Anomalies 4 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possibility that fatty liver (increasingly recognized as non-alcoholic steatohepatitis or NASH) may have roots in the neonatal period is a concept which may have important long-term implications.
NASH Binding (recognized) of in liver associated with fatty liver and nash(non-alcoholic steatohepatitis)
1) Confidence 0.21 Published 2003 Journal Semin Neonatol Section Abstract Doc Link 15001122 Disease Relevance 0.46 Pain Relevance 0.17
Furthermore, NASH is increasingly recognized as a precursor to more severe liver disease, sometimes evolving into "cryptogenic" cirrhosis.
NASH Binding (recognized) of in liver associated with liver disease, nash(non-alcoholic steatohepatitis) and cirrhosis
2) Confidence 0.18 Published 2004 Journal Drug Metab. Rev. Section Abstract Doc Link 15554233 Disease Relevance 1.87 Pain Relevance 0.03
Hypoxia has been implicated as a causative factor in alcohol-induced fatty liver disease [4,5]; however, whether hypoxia is also associated with NAFLD and NASH is not known.
NASH Spec (whether) Binding (associated) of in liver associated with fatty liver, liver disease, nash(non-alcoholic steatohepatitis), hypoxia and alcohol
3) Confidence 0.16 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 1.15 Pain Relevance 0.05
Recently, the involvement of intestinal bacterial flora in the regulation of metabolic homeostasis has been the subject of intense interest.55,56 In particular, studies have revealed that NASH is associated with intestinal bacterial overgrowth and increased intestinal permeability, leading to the endotoxin-dependent activation of KCs.55 This effect was also shown with an HF diet in rats.57 Thus, intestinal effects may add to hepatic effects as causal effectors of HF-linked metabolic abnormalities.
NASH Binding (associated) of associated with nash(non-alcoholic steatohepatitis) and congenital anomalies
4) Confidence 0.14 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.53 Pain Relevance 0.12
which can be associated with nonalcoholic steatohepatitis (NASH) [16].
NASH Binding (associated) of associated with nash(non-alcoholic steatohepatitis)
5) Confidence 0.12 Published 2008 Journal HPB Surgery Section Body Doc Link PMC2599919 Disease Relevance 0.37 Pain Relevance 0
All patients included with histological diagnosis of NASH (borderline or NASH) had steatosis.
NASH Binding (diagnosis) of associated with nash(non-alcoholic steatohepatitis)
6) Confidence 0.06 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.18 Pain Relevance 0.18
All patients included with histological diagnosis of NASH (borderline or NASH) had steatosis.
NASH Binding (diagnosis) of associated with nash(non-alcoholic steatohepatitis)
7) Confidence 0.06 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.24 Pain Relevance 0.21

General Comments

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