INT117033

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2009
Negated 4
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 11.46
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (JAG1) structural molecule activity (JAG1) plasma membrane (JAG1)
Anatomy Link Frequency
oral cavity 1
meninges 1
AWs 1
ducts 1
AGS 1
JAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 10 99.96 Very High Very High Very High
Chronic pancreatitis 8 97.56 Very High Very High Very High
Bile 5 94.44 High High
anesthesia 3 93.48 High High
cytokine 10 80.64 Quite High
spinal inflammation 2 66.36 Quite High
Inflammation 5 61.16 Quite High
backache 2 52.48 Quite High
palliative 4 51.36 Quite High
Paracetamol 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Alagille Syndrome 208 100.00 Very High Very High Very High
Skin Cancer 90 100.00 Very High Very High Very High
Squamous Cell Carcinoma 122 99.84 Very High Very High Very High
Cancer 169 99.76 Very High Very High Very High
Adenocarcinoma 124 99.36 Very High Very High Very High
Apoptosis 22 98.76 Very High Very High Very High
Syndrome 1 98.40 Very High Very High Very High
Pancreatitis 8 97.56 Very High Very High Very High
Congenital Anomalies 82 97.36 Very High Very High Very High
Body Weight 20 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Full maturity takes up to two years after birth to be achieved, and involves the normal expression of signalling pathways such as that responsible for the JAG1 genes (aberrations occur in Alagille's syndrome), amino acid transport and insulin growth factors.
Gene_expression (expression) of JAG1 associated with syndrome
1) Confidence 0.65 Published 2003 Journal Semin Neonatol Section Abstract Doc Link 15001122 Disease Relevance 0.10 Pain Relevance 0.15
However, glottis was not confirmed even with AWS in the oral cavity, and we could not intubate with AWS.
Neg (not) Gene_expression (confirmed) of AWS in oral cavity associated with alagille syndrome
2) Confidence 0.58 Published 2009 Journal Masui Section Abstract Doc Link 19928514 Disease Relevance 0.38 Pain Relevance 0.09
Of note, there was no specific AHD coverage of competencies on collaboration, communication and health advocacy in this formal curriculum cycle (Table 1).
Neg (no) Gene_expression (coverage) of AHD associated with alagille syndrome
3) Confidence 0.53 Published 2007 Journal BMC Med Educ Section Body Doc Link PMC2186308 Disease Relevance 0.85 Pain Relevance 0
For example, there was no specific AHD coverage of competencies on collaboration, communication and health advocacy in the first 3-year formal curriculum cycle, although we were mandated to teach these competencies by the accreditation bodies.
Neg (no) Gene_expression (coverage) of AHD associated with alagille syndrome
4) Confidence 0.53 Published 2007 Journal BMC Med Educ Section Body Doc Link PMC2186308 Disease Relevance 0.33 Pain Relevance 0.05
Interestingly, despite the increase in AW responses during activation, simultaneous deflection of the PW and AWs produced VPM responses that resembled the PW response, as if the AWs were not stimulated.
Gene_expression (produced) of AWs in AWs associated with thalamus
5) Confidence 0.52 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16306412 Disease Relevance 0 Pain Relevance 0.41
Laryngeal views measured by percentage of glottic opening score were improved significantly using the Pentax-AWS.
Gene_expression (using) of Pentax-AWS associated with alagille syndrome
6) Confidence 0.41 Published 2008 Journal Anaesthesia Section Abstract Doc Link 18477277 Disease Relevance 0.66 Pain Relevance 0
Two genes, BMP7 and JAG1, were also among the 23 genes that had 4-fold or greater expression in SCC than in AD reported in a separate paper [29].
Gene_expression (expression) of JAG1 associated with adenocarcinoma and squamous cell carcinoma
7) Confidence 0.33 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.56 Pain Relevance 0
Five out of the 17 genes (CRABP2, CRIP2, FOS, JAG1, and MST1R) were among the differentially expressed markers between AD and SCC in the original report publishing the Database 1 [16].
Gene_expression (expressed) of JAG1 associated with squamous cell carcinoma and adenocarcinoma
8) Confidence 0.33 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.37 Pain Relevance 0
1) Screen using either WOD or AHD as independent indicators;
Gene_expression (using) of AHD associated with alagille syndrome
9) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2613887 Disease Relevance 0.48 Pain Relevance 0.07
The results of this study indicate that WOD and AHD, either independently or in combination, can be used as an effective screening method to detect undiagnosed vertebral deformities.
Gene_expression (used) of AHD associated with alagille syndrome and congenital anomalies
10) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2613887 Disease Relevance 1.33 Pain Relevance 0.05
The use of whole tumor cells as a source of Ags has the theoretical potential to elicit a broader immune response to tumor-associated Ags than it would be achieved by pulsing DCs with defined tumor Ags.
Gene_expression (source) of Ags associated with alagille syndrome and cancer
11) Confidence 0.24 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 1.70 Pain Relevance 0
Here we describe a human DC-vaccine named DC/Apo-Nec composed of autologous ex vivo generated DCs that have phagocytosed an apoptotic/necrotic mixture of four allogeneic melanoma cell lines [21] expressing known melanoma-associated Ags.
Gene_expression (expressing) of Ags associated with alagille syndrome, skin cancer and apoptosis
12) Confidence 0.19 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 1.57 Pain Relevance 0.10
Subsequent immunohistochemical studies have also failed to find cytokeratin expression in the meninges and AGs [44,45,49].
Spec (find) Gene_expression (expression) of AGs in meninges
13) Confidence 0.18 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.09 Pain Relevance 0
Immunohistochemistry showed that Jagged1 was not expressed in normal pancreatic ducts, while it was highly expressed in ectatic ducts.
Neg (not) Gene_expression (expressed) of Jagged1 in ducts
14) Confidence 0.07 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.04 Pain Relevance 0.60
The expression of selected genes in gastric epithelial cells AGS and MKN45 was monitored by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR).
Gene_expression (expression) of AGS in AGS
15) Confidence 0.02 Published 2005 Journal Helicobacter Section Body Doc Link 15904477 Disease Relevance 0 Pain Relevance 0

General Comments

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