INT117043

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.30
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itga1)
Anatomy Link Frequency
leukocyte 2
lymphocyte 1
TMJ 1
Itga1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 6 97.96 Very High Very High Very High
Inflammation 14 97.24 Very High Very High Very High
Spinal cord 2 95.68 Very High Very High Very High
isoflurane 2 94.80 High High
anesthesia 2 94.12 High High
Multiple sclerosis 17 81.12 Quite High
Pain 1 80.04 Quite High
Inflammatory response 1 74.68 Quite High
Snapping jaw 4 50.00 Quite Low
Osteoarthritis 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 37 99.64 Very High Very High Very High
Adhesions 11 98.80 Very High Very High Very High
Central Nervous System Disease 6 97.96 Very High Very High Very High
INFLAMMATION 19 97.24 Very High Very High Very High
Colitis 12 94.40 High High
Multiple Sclerosis 50 93.44 High High
Tick Infestations 3 89.92 High High
Temporomandibular Joint Syndrome 4 87.52 High High
Osteoarthritis 2 86.80 High High
Recurrence 1 82.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P-selectin glycoprotein ligand-1 (PSGL-1) and very late antigen-4 (VLA-4) are expressed on leukocytes and play an important role in leukocyte-endothelial cell adhesive interactions.
Gene_expression (expressed) of VLA-4 in leukocyte
1) Confidence 0.37 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15001428 Disease Relevance 0.39 Pain Relevance 0.13
Monoclonal antibodies 2PH1 (anti-PSGL-1) and PS/2 (anti-VLA-4) or the combination of both were injected intravenously, and leukocyte adhesion was observed for 60 min in colonic submucosal venules by intravital microscopy (IVM) under isoflurane/N(2)O anesthesia.
Gene_expression (injected) of VLA-4 in leukocyte associated with anesthesia, isoflurane and adhesions
2) Confidence 0.28 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15001428 Disease Relevance 0.67 Pain Relevance 0.18
Immunohistostaining was carried out to examine the expression of discoidin domain receptor 2 (Ddr2), a type II collagen receptor, matrix metalloproteinase-13 (Mmp-13), and Mmp-derived type II collagen fragments in the articular cartilage of condyles from the mouse TMJ.
Spec (examine) Gene_expression (expression) of collagen receptor in TMJ
3) Confidence 0.13 Published 2009 Journal Osteoarthr. Cartil. Section Body Doc Link 19230720 Disease Relevance 0.17 Pain Relevance 0
On the fourth day of infestation, the results of flow cytometry indicated that 2% of the host's splenocytes were expressing high levels of CD49 (alpha4 integrin of VLA-4) and low levels of CD11a (alphaL subunit of the integrin LFA-1).
Gene_expression (expressing) of VLA-4
4) Confidence 0.08 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.50 Pain Relevance 0.08
In contrast, splenic T cells showed significantly increased apoptosis, reduced surface levels of LFA-1, CD44 and VLA-4 and impaired lymphocyte migration to the inflamed CNS [19].
Gene_expression (levels) of VLA-4 in lymphocyte associated with central nervous system and apoptosis
5) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 1.56 Pain Relevance 0.38

General Comments

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