INT117050

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.41
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GLA) extracellular region (GLA) Golgi apparatus (GLA)
lysosome (GLA) cytoplasm (GLA)
Anatomy Link Frequency
skin 1
body 1
GLA (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 2 75.00 Quite High
Lasting pain 1 70.52 Quite High
Nicotine 48 46.96 Quite Low
imagery 3 45.76 Quite Low
Dermatone 3 43.04 Quite Low
Pain 13 25.00 Low Low
agonist 54 17.28 Low Low
Glutamate 84 5.00 Very Low Very Low Very Low
Potency 11 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 52 99.48 Very High Very High Very High
Lysosome Storage Disease 7 99.40 Very High Very High Very High
Carpal Tunnel Syndrome 10 95.84 Very High Very High Very High
Disease 15 94.20 High High
Pain 15 70.52 Quite High
Nervous System Injury 2 69.04 Quite High
Lysosomal Storage Diseases 1 68.64 Quite High
Diabetic Nephropathy 2 56.04 Quite High
Targeted Disruption 44 29.28 Quite Low
Congenital Anomalies 5 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the fixed association of ALA and GLA proved to be a useful tool and may be proposed for controlling symptoms and improving the evolution of CTS, especially in the earlier stages of disease.
GLA Binding (association) of associated with carpal tunnel syndrome and disease
1) Confidence 0.47 Published 2009 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 19499849 Disease Relevance 0.44 Pain Relevance 0.07
To understand how the enzyme cleaves galactose from glycoproteins and glycolipids, we also determined the structure of the complex of alpha-GAL with its catalytic product.
alpha-GAL Spec (determined) Binding (complex) of
2) Confidence 0.42 Published 2004 Journal J. Mol. Biol. Section Abstract Doc Link 15003450 Disease Relevance 0.57 Pain Relevance 0.07
Here, a promoter activator binds the GLA promoter in the nuclei of cells and enhances GLA transcription, thereby increasing the synthesis of mutant GLA protein.
GLA promoter Binding (binds) of
3) Confidence 0.37 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.28 Pain Relevance 0
Fabry disease is a rare X-linked lysosomal storage disorder caused by deficient activity of alpha-galactosidase A (alpha-Gal A) resulting in the storage of glycosphingolipids, especially globotriaosylceramide (Gb3), in cells throughout the body, causing life-threatening renal, cardiac, and cerebrovascular complications in hemizygous males and some heterozygous females.
alpha-Gal A Binding (activity) of in body associated with fabry disease and lysosome storage disease
4) Confidence 0.36 Published 2005 Journal Medicine (Baltimore) Section Abstract Doc Link 16148726 Disease Relevance 0.41 Pain Relevance 0
Electromyography showed a statistically significant improvement with ALA/GLA, but not with the multivitamin product.
GLA Binding (improvement) of
5) Confidence 0.36 Published 2009 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 19499849 Disease Relevance 0.45 Pain Relevance 0.07
The statistical relationship of residual GALA enzyme levels to skin-moisture in the analysis model value further corroborates a known association of hidrosis and residual GALA enzyme activity in Fabry disease.
GALA enzyme Binding (association) of in skin associated with fabry disease
6) Confidence 0.31 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2585087 Disease Relevance 0.25 Pain Relevance 0
Human sensory evaluation was also performed using a model soup containing MRPs conjugated with GalA, GlcNH2, and Xyl using a quantitative descriptive analysis and a 7-point intensity scale.
GalA Binding (conjugated) of
7) Confidence 0.09 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0
To test if the effect of MRPs on the Bz-insensitive NaCl CT response is dependent upon the conjugated sugar moiety, the 1000–5000 Da peptide was conjugated with GalA, GlcNH2, Glc, Fru, or Xyl.
GalA Binding (conjugated) of
8) Confidence 0.09 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0
This suggests that ethanol produces mixture interactions with GalA-MRP resulting in a decrease in the salt perception.
GalA Binding (interactions) of
9) Confidence 0.09 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0

General Comments

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