INT11708

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Context Info
Confidence 0.44
First Reported 1988
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.29
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SCT) cellular_component (SCT)
Anatomy Link Frequency
plasma 1
brainstem 1
pancreatic duct 1
Stomach 1
Heart 1
SCT (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 11 100.00 Very High Very High Very High
Cholecystokinin 11 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Somatostatin 1 99.92 Very High Very High Very High
narcan 8 99.40 Very High Very High Very High
fibrosis 2 99.08 Very High Very High Very High
Serotonin 10 98.60 Very High Very High Very High
Acupuncture 26 98.34 Very High Very High Very High
gABA 4 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 61 99.84 Very High Very High Very High
Fibrosis 2 99.08 Very High Very High Very High
Ulcers 7 97.12 Very High Very High Very High
Knee Osteoarthritis 2 97.04 Very High Very High Very High
Exocrine Pancreatic Insufficiency 1 96.80 Very High Very High Very High
Pancreatitis 10 93.72 High High
Gallbladder Disease 12 92.04 High High
Autism 44 88.80 High High
Death 1 74.40 Quite High
Disease 5 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We characterized the effect of exogenous secretin administration on the width of the pancreatic duct in nine healthy domestic cats.
Regulation (effect) of secretin in pancreatic duct
1) Confidence 0.44 Published 2010 Journal Vet Radiol Ultrasound Section Abstract Doc Link 20166401 Disease Relevance 0.19 Pain Relevance 0.20
Likewise, Levy et al. [17] came to the conclusion that a single dose of secretin is not effective in changing behavior and communication in children with PDD if compared to placebo.
Regulation (effective) of secretin
2) Confidence 0.43 Published 2005 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC1308834 Disease Relevance 0.52 Pain Relevance 0
Twelve healthy men were tested in a double-blind intra-subject design receiving either 0.1 IU/kg salmon calcitonin (sCT) or 1.0 IU/kg sCT or saline solution during a 20 min IV infusion. sCT significantly increased latency of wave V of the brainstem auditory evoked potential (BAEP).
Regulation (receiving) of sCT in brainstem associated with medulla
3) Confidence 0.40 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1589561 Disease Relevance 0 Pain Relevance 0.13
OBJECTIVE: To evaluate the effects of oral salmon calcitonin (sCT) on Lequesne's algofunctional index scores and on biomarkers of joint metabolism in knee osteoarthritis.
Regulation (effects) of sCT in knee associated with knee osteoarthritis and osteoarthritis
4) Confidence 0.29 Published 2006 Journal Arthritis Rheum. Section Abstract Doc Link 17009253 Disease Relevance 0.17 Pain Relevance 0.09
Using the "Bi-Digital O-Ring Test Molecular Identification Method", the author also found that within the boundary of most acupuncture points and meridian lines (including Heart, Stomach, and Triple Burner) were high concentrations of neurotransmitters and hormones, including Acetylcholine, Methionine-Enkephalin, Beta-Endorphin, ACTH, Secretin, Cholecystokinin, Norepinephrine, Serotonin, and GABA.
Regulation (concentrations) of Secretin in Heart associated with gaba, neurotransmitter, enkephalin, acupuncture, serotonin and cholecystokinin
5) Confidence 0.28 Published 1989 Journal Acupunct Electrother Res Section Abstract Doc Link 2575347 Disease Relevance 0 Pain Relevance 0.97
Intravenous administration of naloxone (40 micrograms/kg/hr) had no effect on serum gastrin and secretin concentrations or on the gastric acid secretion stimulated by pentagastrin (n = 8).
Neg (no) Regulation (effect) of secretin associated with narcan
6) Confidence 0.21 Published 1993 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 8112709 Disease Relevance 0 Pain Relevance 0.81
The concentrations of secretin and CCK in plasma and the pancreatic enzyme and volume secretions were unaffected by the addition of trypsin, but the initial bile acid output and the bicarbonate secretion in the period after gallbladder emptying were reduced during perfusion with trypsin.
Regulation (concentrations) of secretin in plasma associated with bile and cholecystokinin
7) Confidence 0.17 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3227303 Disease Relevance 0.17 Pain Relevance 0.26
The relaxation of SO following meals is predominantly under the influence of Cholecystokinin and secretin.
Regulation (influence) of secretin associated with cholecystokinin
8) Confidence 0.11 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702883 Disease Relevance 0.18 Pain Relevance 0.14
Using the "Bi-Digital O-Ring Test Molecular Identification Method", the author also found that within the boundary of most acupuncture points and meridian lines (including Heart, Stomach, and Triple Burner) were high concentrations of neurotransmitters and hormones, including Acetylcholine, Methionine-Enkephalin, Beta-Endorphin, ACTH, Secretin, Cholecystokinin, Norepinephrine, Serotonin, and GABA.
Regulation (concentrations) of Secretin in Stomach associated with gaba, neurotransmitter, enkephalin, acupuncture, serotonin and cholecystokinin
9) Confidence 0.10 Published 1989 Journal Acupunct Electrother Res Section Abstract Doc Link 2575347 Disease Relevance 0 Pain Relevance 0.97
As in the study with young adults, neither dose of indiplon-IR produced any significant changes on the DSST, SCT or VAS at any time point.
Neg (neither) Regulation (changes) of SCT associated with sleep disorders
10) Confidence 0.09 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.41 Pain Relevance 0
However, there were no significant changes in sereum ir-secretin, somatostatin, and vasoactive intestinal polypeptide levels as well as ulcer healing and HP prevalence between the two groups.
Neg (no) Regulation (changes) of ir-secretin associated with ulcers and somatostatin
11) Confidence 0.09 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7821104 Disease Relevance 0.64 Pain Relevance 0.19
Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin.
Regulation (Sensitivity) of secretin associated with neuropeptide
12) Confidence 0.08 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 10860858 Disease Relevance 0 Pain Relevance 0.31

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