INT117095

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.35
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabra5)
Anatomy Link Frequency
spinal cord 2
dorsal root ganglia 1
Gabra5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 6 99.92 Very High Very High Very High
Peripheral nerve injury 12 98.00 Very High Very High Very High
Spinal cord 12 97.28 Very High Very High Very High
Neuropathic pain 3 94.48 High High
Dorsal horn 3 84.56 Quite High
central sensitization 3 78.32 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 12 98.00 Very High Very High Very High
Neuropathic Pain 3 94.48 High High
Injury 3 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increases in Ca2+ channel alpha2/delta1 subunit, GABAA receptor alpha5 subunit, Na+ channels and nicotinic acetylcholine receptors in both dorsal spinal cord and dorsal root ganglia indicate their potential roles in neuropathic pain control.
Positive_regulation (Increases) of GABAA receptor alpha5 subunit in dorsal root ganglia associated with neuropathic pain and spinal cord
1) Confidence 0.20 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15009134 Disease Relevance 0.48 Pain Relevance 0.56
These regulated genes included Ca2+ channel alpha1E and alpha2/delta1 subunits, alpha subunits for Na+ channel 1 and 6, Na+ channel beta subunit, AMAP receptor GluR3 and 4, GABAA receptor alpha5 subunit, nicotinic acetylcholine receptor alpha5 and beta2 subunits, PKC alpha, betaI and delta isozymes, JNK1-3, ERK2-3, p38 MAPK and BatK and Lyn tyrosine-protein kinases, indicating that several signal transduction pathways were activated in dorsal spinal cord by peripheral nerve injury.
Positive_regulation (included) of GABAA receptor alpha5 subunit in spinal cord associated with nervous system injury, peripheral nerve injury and spinal cord
2) Confidence 0.15 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15009134 Disease Relevance 0.40 Pain Relevance 0.53
Increases in Ca2+ channel alpha2/delta1 subunit, GABAA receptor alpha5 subunit, Na+ channels and nicotinic acetylcholine receptors in both dorsal spinal cord and dorsal root ganglia indicate their potential roles in neuropathic pain control.
Positive_regulation (Increases) of GABAA receptor alpha5 subunit in spinal cord associated with neuropathic pain and spinal cord
3) Confidence 0.07 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15009134 Disease Relevance 0.48 Pain Relevance 0.56

General Comments

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