INT117096

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.68
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Wnt4) Golgi apparatus (Wnt4) cell-cell signaling (Wnt4)
cytoplasm (Wnt4) anatomical structure development (Wnt4) extracellular space (Wnt4)
Anatomy Link Frequency
ducts 2
sciatic nerve 1
uterine 1
Wnt4 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 2 99.66 Very High Very High Very High
hyperexcitability 1 99.26 Very High Very High Very High
Peripheral nerve injury 4 94.16 High High
pain pelvic 4 75.36 Quite High
spinal dorsal horn 2 75.28 Quite High
qutenza 2 25.00 Low Low
Dorsal horn 1 25.00 Low Low
c fibre 1 25.00 Low Low
imagery 24 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 260 100.00 Very High Very High Very High
Nervous System Injury 9 99.90 Very High Very High Very High
Hyperandrogenism 16 99.08 Very High Very High Very High
Aplasia 116 97.92 Very High Very High Very High
Infertility 20 97.08 Very High Very High Very High
Congenital Anomalies 21 92.20 High High
Cv General 4 Under Development 4 88.80 High High
Polydactyly 8 87.44 High High
Confusion 4 85.84 High High
Diabetes Mellitus 12 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This new syndrome due to WNT4 mutations in XX women and characterized by absence of Müllerian ducts derivatives, hyperandrogenism and kidney optional adysplasia [80,81], is close but different from MRKH syndrome; therefore, it should be referred to as a proper name, such as "WNT4 syndrome" or "WNT4 defects" and be consequently recorded under an appropriate OMIM number.
Gene_expression (syndrome) of WNT4 in ducts associated with syndrome and hyperandrogenism
1) Confidence 0.67 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1832178 Disease Relevance 1.00 Pain Relevance 0
The dominant-negative mutation of WNT4 may then produce two distinct effects, hyperandrogenism and uterine aplasia.
Gene_expression (produce) of WNT4 in uterine associated with aplasia and hyperandrogenism
2) Confidence 0.59 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1832178 Disease Relevance 0.53 Pain Relevance 0
WNT4 defects
Gene_expression (defects) of WNT4
3) Confidence 0.58 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1832178 Disease Relevance 1.55 Pain Relevance 0.08
This new syndrome due to WNT4 mutations in XX women and characterized by absence of Müllerian ducts derivatives, hyperandrogenism and kidney optional adysplasia [80,81], is close but different from MRKH syndrome; therefore, it should be referred to as a proper name, such as "WNT4 syndrome" or "WNT4 defects" and be consequently recorded under an appropriate OMIM number.
Gene_expression (defects) of WNT4 in ducts associated with syndrome and hyperandrogenism
4) Confidence 0.58 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1832178 Disease Relevance 1.00 Pain Relevance 0
In the present study, we examined the involvement of these pathways in the development of hyperexcitability after sciatic nerve injury (SNI) by detecting the intracellular signal molecule.
Gene_expression (detecting) of signal molecule in sciatic nerve associated with nervous system injury, sciatic nerve and hyperexcitability
5) Confidence 0.01 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15009135 Disease Relevance 0.61 Pain Relevance 0.31

General Comments

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