INT11710

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.15
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINC1) extracellular region (SERPINC1) plasma membrane (SERPINC1)
Anatomy Link Frequency
plasma 2
blood 1
platelet 1
SERPINC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 13 99.52 Very High Very High Very High
cva 16 96.88 Very High Very High Very High
Inflammation 47 96.16 Very High Very High Very High
corticosteroid 1 95.92 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 3 84.84 Quite High
Central nervous system 13 79.72 Quite High
ischemia 3 76.76 Quite High
Migraine 61 76.20 Quite High
carpal tunnel syndrome 13 72.48 Quite High
Peripheral nervous system 1 70.80 Quite High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 4 100.00 Very High Very High Very High
Polymyositis 5 98.20 Very High Very High Very High
Coagulation Disorder 11 97.28 Very High Very High Very High
Cv General 3 Under Development 13 96.88 Very High Very High Very High
Thrombosis 20 96.64 Very High Very High Very High
INFLAMMATION 49 96.16 Very High Very High Very High
Cytomegalovirus Infection 23 94.64 High High
Arrhythmia Under Development 2 92.40 High High
Body Weight 3 89.12 High High
Livedo Reticularis 2 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of thrombin-antithrombin III complex (TAT) was markedly increased in Patient 1.
Positive_regulation (increased) of antithrombin
1) Confidence 0.59 Published 1996 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8752690 Disease Relevance 1.22 Pain Relevance 0.25
Most were also investigated with electrocardiograms, ultrasound of the precerebral vessels and cerebral magnetic resonance imaging (MRI), as well as extensive blood chemistry screening for coagulation parameters, hemoglobin (Hb), platelet count, erythrocyte sedimentation rate (ESR), activated partial thromboplastin time (APPT), fibrinogen, protein S and C, lupus anticoagulant and anticardiolipin antibodies, homocystein and antithrombin 3.
Spec (partial) Positive_regulation (activated) of antithrombin 3 in blood associated with systemic lupus erythematosus and imagery
2) Confidence 0.45 Published 2007 Journal BMC Med Section Body Doc Link PMC1939710 Disease Relevance 0.30 Pain Relevance 0.42
In addition, clinical manifestations, coronary arteriographic findings, and increased plasma levels of thrombin-antithrombin III complex suggest that cardiac involvement in polymyositis accelerates intracoronary thrombus formation and/or coronary spasm.
Positive_regulation (increased) of thrombin-antithrombin III in plasma associated with polymyositis, cva and thrombosis
3) Confidence 0.43 Published 1992 Journal Kokyu To Junkan Section Abstract Doc Link 1589649 Disease Relevance 1.27 Pain Relevance 0.47
Furthermore, biologically, the effect of antithrombin may be modified directly by bacterial endotoxins because porins (nonspecific channels of the bacterial outer membrane that allow transmembrane passage of nutrient molecules that are usually small and hydrophilic) not only enhanced thrombin activity but also inhibited the enhanced antithrombin activity resulting from antithrombin administration [74].
Positive_regulation (enhanced) of antithrombin
4) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.42 Pain Relevance 0.03
However, supranormal levels have not been achieved in human trials because the highest dose regimens could only induce 200–250% antithrombin activity.
Positive_regulation (induce) of antithrombin
5) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.91 Pain Relevance 0.13
No pathological values for prothrombin time ratio, activated partial thromboplastin time, plasma antithrombin III, protein C and S activity were found.
Positive_regulation (activated) of antithrombin III in plasma
6) Confidence 0.12 Published 2005 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1198216 Disease Relevance 1.50 Pain Relevance 0.11
Earlier studies have shown correlation between TEG variables and routine coagulation tests (platelet count, prothrombin time, activated partial thromboplastin time, antithrombin and fibrinogen) [9,10].
Spec (partial) Positive_regulation (activated) of antithrombin in platelet
7) Confidence 0.03 Published 2009 Journal Thromb J Section Body Doc Link PMC2777119 Disease Relevance 0.53 Pain Relevance 0.06

General Comments

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