INT117100

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.18
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
aorta 4
endothelial cells 2
Sod1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 55 94.52 High High
allodynia 21 88.72 High High
Potency 8 87.92 High High
B1 receptor 91 82.92 Quite High
cINOD 6 73.52 Quite High
antagonist 13 44.96 Quite Low
Bioavailability 16 42.68 Quite Low
cOX1 2 25.00 Low Low
bradykinin 13 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 43 94.76 High High
Insulin Resistance 25 89.64 High High
Neuropathic Pain 26 88.72 High High
Pressure And Volume Under Development 27 88.28 High High
Diabetes Mellitus 25 74.24 Quite High
INFLAMMATION 14 73.04 Quite High
Obesity 37 59.92 Quite High
Increased Venous Pressure Under Development 24 46.12 Quite Low
Body Weight 14 41.44 Quite Low
Hypertension 4 5.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with previous reports in porcine aorta showing that chronic exercise training increases SOD-1 expression associated with improvement in relaxing response [42,43].
Positive_regulation (increases) of Gene_expression (expression) of SOD-1 in aorta
1) Confidence 0.60 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0 Pain Relevance 0.04
Interestingly, in both aortic and mesenteric rings, an increase in SOD-1 expression in trained groups was found.
Positive_regulation (increase) of Gene_expression (expression) of SOD-1
2) Confidence 0.60 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0 Pain Relevance 0.11
Data from Western blotting analysis in isolated aorta and mesenteric arteries from trained animals fed with standard chow or high caloric diet (TR and TRD groups) showed an increase in the expression of antioxidant enzyme SOD-1, approximately 30%.
Positive_regulation (increase) of Gene_expression (expression) of SOD-1 in aorta
3) Confidence 0.41 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.11 Pain Relevance 0.11
Therefore, our findings clearly show a strong relationship between the improvement in relaxing response seen in trained animals and up-regulation of SOD-1 expression.
Positive_regulation (regulation) of Gene_expression (expression) of SOD-1
4) Confidence 0.41 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0 Pain Relevance 0.07
The results of the present studies also reveal that melatonin may influence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment.
Spec (may) Positive_regulation (influence) of Gene_expression (expression) of Cu-Zn SOD
5) Confidence 0.40 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15009511 Disease Relevance 0.14 Pain Relevance 0.22
The results of the present studies also reveal that melatonin may influence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment.
Spec (may) Positive_regulation (influence) of Gene_expression (expression) of Cu-Zn SOD
6) Confidence 0.40 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15009511 Disease Relevance 0.14 Pain Relevance 0.22
Exposure of human endothelial cells to 20 mM glucose for 1–2 weeks increased mRNA expression of CuZnSOD and MnSOD [48].
Positive_regulation (increased) of Gene_expression (expression) of CuZnSOD in endothelial cells
7) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.78 Pain Relevance 0.43

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