INT117101

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 7.93
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
embryos 3
aorta 2
endothelial cells 2
plasma 1
mesenteric artery 1
Sod1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 115 93.96 High High
allodynia 21 88.12 High High
Potency 23 87.28 High High
B1 receptor 91 82.32 Quite High
cINOD 6 72.96 Quite High
Bioavailability 40 57.56 Quite High
Spinal cord 39 46.00 Quite Low
antagonist 13 44.96 Quite Low
anesthesia 16 35.40 Quite Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 203 99.82 Very High Very High Very High
Motor Neuron Diseases 64 99.72 Very High Very High Very High
Disease 126 98.24 Very High Very High Very High
Gestational Diabetes 27 98.08 Very High Very High Very High
Diabetes Mellitus 190 97.00 Very High Very High Very High
Obesity 91 96.96 Very High Very High Very High
Disease Progression 10 95.80 Very High Very High Very High
Stress 70 94.16 High High
Pressure And Volume Under Development 42 93.40 High High
Increased Venous Pressure Under Development 60 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, to assess the underlying mechanisms by which exercise training ameliorates the vascular responsiveness in this particular model we have chosen to analyze SOD-1 expression in both arteries and plasma NOx- concentration for two reasons.
Spec (analyze) Gene_expression (expression) of SOD-1 in plasma
1) Confidence 0.67 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.06 Pain Relevance 0.13
This is consistent with previous reports in porcine aorta showing that chronic exercise training increases SOD-1 expression associated with improvement in relaxing response [42,43].
Gene_expression (expression) of SOD-1 in aorta
2) Confidence 0.67 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0 Pain Relevance 0.04
In order to evaluate the contribution of Cu/Zn superoxide dismutase (SOD-1) in endothelial cells in response to exercise training, aortic and mesenteric expression of SOD-1 was determined by Western blotting assays.
Gene_expression (expression) of SOD-1 in endothelial cells
3) Confidence 0.67 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.05 Pain Relevance 0
Therefore, our findings clearly show a strong relationship between the improvement in relaxing response seen in trained animals and up-regulation of SOD-1 expression.
Gene_expression (expression) of SOD-1
4) Confidence 0.67 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0 Pain Relevance 0.05
Interestingly, in both aortic and mesenteric rings, an increase in SOD-1 expression in trained groups was found.
Gene_expression (expression) of SOD-1
5) Confidence 0.67 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0 Pain Relevance 0.11
The results of the present studies also reveal that melatonin may influence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment.
Gene_expression (expression) of Cu-Zn SOD
6) Confidence 0.61 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15009511 Disease Relevance 0.14 Pain Relevance 0.22
Sexual dimorphism in phenotypic onset has also been observed in an ALS animal model expressing mutant human SOD1 genes [26]–[29].
Gene_expression (expressing) of SOD1 associated with motor neuron diseases
7) Confidence 0.56 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2845661 Disease Relevance 2.06 Pain Relevance 0
Transgenic rats expressing the mutant TDP gene displayed a wider range of neurodegeneration than transgenic rodents expressing mutant SOD1 genes [29], [52]–[54], with neurodegeneration predominantly affecting the motor system.
Gene_expression (expressing) of SOD1 associated with targeted disruption
8) Confidence 0.56 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2845661 Disease Relevance 1.68 Pain Relevance 0
The results of the present studies also reveal that melatonin may influence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment.
Gene_expression (expression) of Cu-Zn SOD
9) Confidence 0.53 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15009511 Disease Relevance 0.14 Pain Relevance 0.22
We found decreased gene expression of CuZnSOD, MnSOD, and Gpx-1 in MD embryos (both nonmalformed embryos of STZ-induced diabetic rats [MDn group] and malformed littermates [MDm group]) compared with N embryos.
Gene_expression (expression) of CuZnSOD in embryos associated with diabetes mellitus
10) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.45 Pain Relevance 0
One important finding in the present study was that maternal diabetes diminishes the antioxidative defense gene expression in the embryos, as evidenced by decreased expression of CuZnSOD, MnSOD, and Gpx-1 in MDn and MDm offspring, which may be responsible for a decrease in AOE activity (52).
Gene_expression (expression) of CuZnSOD in embryos associated with gestational diabetes
11) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.25 Pain Relevance 0
Thus, expression of copper zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), and sonic hedgehog homolog (Shh) were decreased, and bone morphogenetic protein-4 (Bmp-4) was increased, in the MD embryos compared with the N embryos.
Gene_expression (expression) of CuZnSOD in embryos
12) Confidence 0.53 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2584142 Disease Relevance 0.61 Pain Relevance 0
Expression of Cu/Zn superoxide dismutase (SOD-1) was assessed by Western blotting.


Gene_expression (Expression) of SOD-1
13) Confidence 0.52 Published 2008 Journal BMC Physiol Section Abstract Doc Link PMC2443377 Disease Relevance 0.34 Pain Relevance 0
Data from Western blotting analysis in isolated aorta and mesenteric arteries from trained animals fed with standard chow or high caloric diet (TR and TRD groups) showed an increase in the expression of antioxidant enzyme SOD-1, approximately 30%.
Gene_expression (expression) of SOD-1 in aorta
14) Confidence 0.52 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.11 Pain Relevance 0.11
The present study is the first to show that physical preconditioning at moderate intensity restores the impairment of relaxing response in mesenteric rings from high caloric diet-fed rats, which was positively associated with reduction in triglycerides concentration and up-regulation in SOD-1 expression.
Gene_expression (expression) of SOD-1
15) Confidence 0.52 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.46 Pain Relevance 0.06
In mesenteric artery, SOD-1 expression was significantly reduced in SDD animals, but not in aortic rings (Figure 5).


Gene_expression (expression) of SOD-1 in mesenteric artery
16) Confidence 0.52 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.18 Pain Relevance 0.11
Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats

Background

Gene_expression (expression) of SOD-1
17) Confidence 0.52 Published 2008 Journal BMC Physiol Section Title Doc Link PMC2443377 Disease Relevance 0.47 Pain Relevance 0
Exposure of human endothelial cells to 20 mM glucose for 1–2 weeks increased mRNA expression of CuZnSOD and MnSOD [48].
Gene_expression (expression) of CuZnSOD in endothelial cells
18) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.77 Pain Relevance 0.43
Another parallel was that high glucose sensitivity correlated with high peroxiredoxin and superoxide dismutase 1 expression, suggesting that oxidative radical scavenging preserves normal glucose sensing.
Gene_expression (expression) of superoxide dismutase 1
19) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0.15 Pain Relevance 0

General Comments

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