INT117112

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 87
Total Number 98
Disease Relevance 40.34
Pain Relevance 31.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
hippocampus 2
muscle 2
nucleus accumbens 2
neuronal 2
neurons 2
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 149 100.00 Very High Very High Very High
qutenza 23 100.00 Very High Very High Very High
Kinase C 71 99.80 Very High Very High Very High
midbrain 9 99.76 Very High Very High Very High
Hippocampus 39 99.64 Very High Very High Very High
antagonist 334 99.52 Very High Very High Very High
Anterior cingulate cortex 102 99.52 Very High Very High Very High
GABAergic 13 99.52 Very High Very High Very High
intrathecal 44 99.48 Very High Very High Very High
Morphine 63 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 341 100.00 Very High Very High Very High
Pain 190 100.00 Very High Very High Very High
Targeted Disruption 177 99.78 Very High Very High Very High
Frailty 242 99.60 Very High Very High Very High
Nervous System Injury 64 99.24 Very High Very High Very High
INFLAMMATION 466 99.12 Very High Very High Very High
Reprotox - General 1 170 99.12 Very High Very High Very High
Neuropathic Pain 78 99.12 Very High Very High Very High
Hypersensitivity 49 99.00 Very High Very High Very High
Muscular Atrophy 143 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased number of unmyelinated fibers in the DN MEK mice could be a result of reduced ERK activity during development.
Negative_regulation (reduced) of ERK associated with unmyelinated
1) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.39 Pain Relevance 0.54
A recent paper reported decreased basal ERK activity in the hippocampi of the DN MEK mice [31].
Negative_regulation (decreased) of ERK
2) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.33 Pain Relevance 0.29
It is unlikely that the decrease in basal hippocampal ERK activity could produce decreased nociception in the DN MEK mice.
Negative_regulation (decrease) of ERK associated with nociception
3) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.51 Pain Relevance 0.36
Furthermore, U0126, a specific inhibitor of the ERK pathway suppressed the persistent pain by formalin.
Negative_regulation (inhibitor) of ERK associated with pain and lasting pain
4) Confidence 0.52 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17662046 Disease Relevance 0.93 Pain Relevance 1.13
We found here for the first time that nerve injury produces a sustained and significant reduction in protein levels of phosphorylated-ERK and -p38 in cytosolic preparations of the mouse lower midbrain.
Negative_regulation (reduction) of ERK in midbrain associated with nervous system injury and midbrain
5) Confidence 0.51 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15009639 Disease Relevance 0.34 Pain Relevance 1.22
The inhibition of ERK activity by i.c.v. pre-treatment with either PD98059 or U0126 impaired the morphine-induced place preference.
Negative_regulation (inhibition) of ERK associated with morphine
6) Confidence 0.51 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15009639 Disease Relevance 0.32 Pain Relevance 1.31
As an underlying mechanism of COX-2 inhibition, these extracts diminished TPA-stimulated catalytic activity of extracellular signal-regulated protein kinase (ERK), which is known to regulate the activation of eukaryotic transcription factors mediating COX-2 induction.
Negative_regulation (diminished) of ERK
7) Confidence 0.46 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.41 Pain Relevance 0.21
evidence was published on the combined use of ERK cascade inhibition and PPAR?
Negative_regulation (inhibition) of ERK cascade
8) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.66 Pain Relevance 0.11
Cocaine and delta-9-tetrahydrocannabinol (THC) activate extracellular signal-regulated kinase (ERK) in the striatum and blockade of the ERK pathway prevents establishment of conditioned place preference to these drugs.
Negative_regulation (blockade) of ERK in striatum associated with delta-9-tetrahydrocannabinol and cocaine
9) Confidence 0.43 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078556 Disease Relevance 0 Pain Relevance 0.43
Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis.
Negative_regulation (reduced) of ERK in hippocampus associated with qutenza, hippocampus and neurodegenerative disease
10) Confidence 0.42 Published 2010 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 20954075 Disease Relevance 0.55 Pain Relevance 0.84
If it were the case, blockade of the ERK pathway by SL327 would not impair the induction of locomotor sensitization but only its expression.
Negative_regulation (blockade) of ERK
11) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.07
A significant inhibition of ERK activation was observed in all the analyzed regions of mice pre-treated with 30 mg/kg of SL327.
Negative_regulation (inhibition) of ERK
12) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.19
The acute locomotor responses were only moderately affected by the pharmacological blockade of ERK pathway by systemic administration of the selective MEK inhibitor, SL327.
Negative_regulation (blockade) of ERK
13) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.19
These results clearly showed that the D-amph-induced behavioral sensitization did not develop if the ERK pathway was blocked before each D-amph treatment.
Negative_regulation (blocked) of ERK
14) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.23
Furthermore, direct inhibition of the ERK signaling cascade in vivo using the MEK inhibitor SL327 recapitulates the actions of psychostimulants in hyperactive mice and prevents the locomotor-enhancing effects of amphetamine in normal animals.
Negative_regulation (inhibition) of ERK
15) Confidence 0.41 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954211 Disease Relevance 0.52 Pain Relevance 0.31
However, administration of amphetamine or methylphenidate to these mice reveals that inhibition of ERK signaling is a common determinant for the ability of these drugs to antagonize hyperactivity.
Negative_regulation (inhibition) of ERK associated with attention deficit hyperactivity disorder
16) Confidence 0.41 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954211 Disease Relevance 0.60 Pain Relevance 0.44
However, anti-NGF treatment did not reduce p-ERK and c-Fos expression at 20 and 90 min, respectively, following fracture.
Neg (not) Negative_regulation (reduce) of ERK
17) Confidence 0.41 Published 2007 Journal Pain Section Abstract Doc Link 17693023 Disease Relevance 0.93 Pain Relevance 0.94
We previously showed that in mice, there is a reduced second phase of licking/lifting behavior following attenuation of ERK activity by intrathecal injection of the MEK inhibitor, PD 98059 [7].
Negative_regulation (attenuation) of ERK associated with intrathecal
18) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.59 Pain Relevance 0.52
We show here, using transgenic mice with reduced neuronal ERK activity, that neuronal ERK plays a key role in the development of inflammatory nociceptive behavior, and contributes to the processing of thermal hyperalgesia.
Negative_regulation (reduced) of ERK in neuronal associated with nociception, targeted disruption, inflammation and thermal hyperalgesia
19) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 1.06 Pain Relevance 0.59
Furthermore, bupivacaine significantly diminished the ERK activation, which may underlie its anti-proliferative actions.
Negative_regulation (diminished) of ERK
20) Confidence 0.41 Published 2010 Journal Acta Pharmacol. Sin. Section Body Doc Link 20228829 Disease Relevance 0.06 Pain Relevance 0

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