INT117116

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.57
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
melanocytes 4
epidermis 2
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 26 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
antagonist 1 98.68 Very High Very High Very High
cytokine 2 84.64 Quite High
Neuropeptide 2 83.40 Quite High
Inflammation 2 77.52 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 14 99.84 Very High Very High Very High
Freckles 14 97.22 Very High Very High Very High
Premature Aging 1 91.60 High High
Malignant Neoplastic Disease 3 79.40 Quite High
INFLAMMATION 2 77.52 Quite High
Stress 2 75.00 Quite High
Erythema 1 62.20 Quite High
Blister 2 56.24 Quite High
Melanoma 3 53.64 Quite High
Ocular Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.
Positive_regulation (mediated) of Positive_regulation (activation) of MC1R in melanocytes associated with melanocortin 1 receptor
1) Confidence 0.49 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19659742 Disease Relevance 0.23 Pain Relevance 0.36
The effect of alpha-MSH on 8-oxodG induction was mediated by activation of the melanocortin 1 receptor (MC1R), as it was absent in melanocytes expressing loss-of-function MC1R, and blocked by concomitant treatment with an analog of agouti signaling protein (ASIP), ASIP-YY.
Positive_regulation (mediated) of Positive_regulation (activation) of melanocortin 1 receptor in melanocytes associated with melanocortin 1 receptor
2) Confidence 0.49 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19659742 Disease Relevance 0.23 Pain Relevance 0.36
Exposure to UVR increases the synthesis of the photoprotective eumelanin on activation of MC1R, a melanoma susceptibility gene.
Positive_regulation (increases) of Positive_regulation (activation) of MC1R associated with skin cancer
3) Confidence 0.48 Published 2006 Journal FASEB J. Section Abstract Doc Link 16877522 Disease Relevance 0.20 Pain Relevance 0.07
Activation of the MC1R by binding of an agonist stimulates the synthesis of eumelanin primarily via activation of adenylate cyclase.
Positive_regulation (stimulates) of Positive_regulation (Activation) of MC1R associated with melanocortin 1 receptor and agonist
4) Confidence 0.44 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.14 Pain Relevance 0.83
A charge-changing mutation at the position homologous to 92 (E92K) is associated with melanism in mice, chicken, quail and bananaquit (Coereba flaveola)[19-21,8] and in vitro studies in mouse and chicken have shown that the mutation causes constitutive activation of MC1R [19,22].
Positive_regulation (causes) of Positive_regulation (activation) of MC1R associated with freckles
5) Confidence 0.40 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2553801 Disease Relevance 0.35 Pain Relevance 0
Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo.
Positive_regulation (radiation-induced) of Positive_regulation (upregulation) of melanocortin-1 receptor in epidermis associated with melanocortin 1 receptor
6) Confidence 0.36 Published 2004 Journal J. Invest. Dermatol. Section Title Doc Link 15009732 Disease Relevance 0.38 Pain Relevance 0.29
Therapeutic use of MC1R-specific antibodies targeting cytokine-induced MC1R potentially requires expression of the target molecule on the surfaces of tumor cells.
Positive_regulation (requires) of Positive_regulation (cytokine-induced) of MC1R
7) Confidence 0.35 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17325166 Disease Relevance 0.05 Pain Relevance 0

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