INT117117

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 10.10
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (REM1) GTPase activity (REM1)
Anatomy Link Frequency
neuronal 1
eye 1
stage 1 1
egg 1
REM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 23 99.92 Very High Very High Very High
Clonidine 12 99.70 Very High Very High Very High
abdominal pain 15 99.46 Very High Very High Very High
addiction 31 98.22 Very High Very High Very High
primary somatosensory cortex 150 98.02 Very High Very High Very High
Hippocampus 189 96.76 Very High Very High Very High
gABA 6 96.64 Very High Very High Very High
agonist 12 93.36 High High
Analgesic 3 84.64 Quite High
anticonvulsant 3 79.48 Quite High
Disease Link Frequency Relevance Heat
Apnoea 55 99.96 Very High Very High Very High
Suicidal Behaviour 1032 99.90 Very High Very High Very High
Gastric Motility Disorder 105 99.78 Very High Very High Very High
Abdominal Pain 15 99.46 Very High Very High Very High
Schizophrenia 606 99.08 Very High Very High Very High
Disease 75 98.28 Very High Very High Very High
Heart Rate Under Development 3 95.68 Very High Very High Very High
Premenstrual Syndrome 103 95.60 Very High Very High Very High
Hallucination 106 94.36 High High
Fever 3 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low-dose clonidine significantly increased the amount of REM sleep and decreased the amount of non-REM (NREM) sleep during the second one-third of the drug nights compared to the corresponding hours of baseline night recordings.
Positive_regulation (increased) of REM associated with clonidine
1) Confidence 0.40 Published 2004 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 15009817 Disease Relevance 0 Pain Relevance 1.01
Similarly, of the 62 GES, 32(51%), 17 men and 15 women had knowledge on CAMs and 18(29%), five men and 13 women, had personally experienced CAMs.
Positive_regulation (had) of GES
2) Confidence 0.17 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2862934 Disease Relevance 0 Pain Relevance 0.06
Because of the dependence of REM sleep on the integrity of the cholinergic system, theoretically, one may predict increased REM sleep in cholinesterase inhibitor-treated AD patients [90].
Positive_regulation (increased) of REM associated with addiction and disease
3) Confidence 0.16 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.85 Pain Relevance 0.09
Keshavan et al. [38] found that those schizophrenic patients who exhibited suicidal behavior had increased overall REM activity and REM time.
Positive_regulation (increased) of REM associated with suicidal behaviour and schizophrenia
4) Confidence 0.13 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1845151 Disease Relevance 1.55 Pain Relevance 0.04
Keshavan et al. [38] found that those schizophrenic patients who exhibited suicidal behavior had increased overall REM activity and REM time.
Positive_regulation (increased) of REM associated with suicidal behaviour and schizophrenia
5) Confidence 0.13 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1845151 Disease Relevance 1.56 Pain Relevance 0.04
These findings might explane the anti-suicidal role of clozapine since increasing REM sleep has been correlated with increased suicide risk.
Positive_regulation (increasing) of REM associated with suicidal behaviour
6) Confidence 0.12 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1845151 Disease Relevance 1.68 Pain Relevance 0
-aminobutyric acid; GG = genioglossus (muscle); OSA = obstructive sleep apnoea; REM = rapid eye movement; SSRI = selective serotonin reuptake inhibitors; TRH = thyrotropin-releasing hormone.



Positive_regulation (movement) of REM in eye associated with apnoea and ssri
7) Confidence 0.08 Published 2001 Journal Respir Res Section Body Doc Link PMC59518 Disease Relevance 0.48 Pain Relevance 0.18
Reference [52] Total sleep time, SE (%), SWS (min), and REM sleep (min and %) were increased, whereas SOL (min), ROL (min), WASO, stage 1 sleep (min and %), and stage 2 sleep (%) were decreased.
Positive_regulation (increased) of REM in stage 1
8) Confidence 0.06 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.99 Pain Relevance 0
Spindle-range LFP activity in itself is certainly not sufficient to induce IEG expression, or else SWS and IS would also lead to IEG upregulation, like REM sleep does.
Positive_regulation (upregulation) of REM
9) Confidence 0.03 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.16 Pain Relevance 0.07
Post-experience reactivation of neuronal firing in S1 peaked during SWS (Figure 3), while IEG expression linked to synaptic remodeling was specifically upregulated during post-stimulation REM sleep episodes (Figures 4A and 4B).
Positive_regulation (upregulated) of REM in neuronal associated with primary somatosensory cortex
10) Confidence 0.03 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.08 Pain Relevance 0.37
Despite the link between cortical IEG upregulation and post-experience REM sleep, analysis of the relation between IEG expression in S1 and time spent in REM sleep within 60?
Positive_regulation (upregulation) of REM associated with primary somatosensory cortex
11) Confidence 0.03 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.24 Pain Relevance 0.62
Patients then underwent GES by consuming a meal of one whole scrambled egg (85 calories) with 2 pieces of white bread (133 calories)/1 pat of butter (36 calories) and 50-100 cm3 of water for a total calorie count of 254 calories.
Positive_regulation (underwent) of GES in egg associated with heart rate under development
12) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978393 Disease Relevance 0.93 Pain Relevance 0.24
Consecutive patients with chronic abdominal pain or suspected GP (n = 120) underwent GES performed as part of their diagnostic medical workup.
Positive_regulation (underwent) of GES associated with abdominal pain and gastric motility disorder
13) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978393 Disease Relevance 1.05 Pain Relevance 0.31
This study is a retrospective case-control analysis of 120 patients who underwent GES with provocative testing at the University of Florida department of Nuclear Medicine from July to November 2009.
Positive_regulation (underwent) of GES
14) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978393 Disease Relevance 0.55 Pain Relevance 0.31

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