INT117120

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 6.53
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Krt14) structural molecule activity (Krt14) nucleus (Krt14)
intracellular (Krt14) cytoplasm (Krt14)
Anatomy Link Frequency
basal cells 2
neuronal 1
filament 1
epithelium 1
peripheral nervous system 1
Krt14 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 55 100.00 Very High Very High Very High
Peripheral nervous system 3 98.68 Very High Very High Very High
Hippocampus 5 88.08 High High
Intracerebroventricular 3 84.80 Quite High
Trigeminal ganglion neurons 1 84.80 Quite High
monoamine 1 77.88 Quite High
withdrawal 4 75.28 Quite High
Spinal cord 5 73.28 Quite High
agonist 10 60.16 Quite High
long-term potentiation 2 54.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 187 99.98 Very High Very High Very High
Cold Sores 89 99.56 Very High Very High Very High
Cancer 1504 98.90 Very High Very High Very High
Sprains And Strains 45 95.40 Very High Very High Very High
Hyperplasia 14 94.16 High High
Apoptosis 36 92.88 High High
Acanthosis 8 86.72 High High
Death 17 85.48 High High
Ganglion Cysts 3 83.92 Quite High
Skin Diseases 6 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, stratified epithelia, like epidermis, express K5/K14 in the basal and K1/K10 in the suprabasal keratinocytes, respectively (Moll et al. 1982; Lane and McLean 2004; Coulombe and Omary 2002).
Gene_expression (express) of K14 in keratinocytes
1) Confidence 0.75 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0 Pain Relevance 0
Such a proliferation-promoting role of Krt14 has been demonstrated in transgenic mice overexpressing Krt14 in pulmonary epithelium [62].
Gene_expression (overexpressing) of Krt14 in epithelium associated with targeted disruption
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.61 Pain Relevance 0
Tumors grown from transplanted G-2 cells (Figure 5A) recapitulated the distinctive features of high-grade WAP-T tumors (Figure 5B), namely a moderate proportion of cells co-expressing Krt14 and Krt8/18.
Gene_expression (expressing) of Krt14 associated with cancer
3) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 1.61 Pain Relevance 0
In subsequent passages slight variations in the individual expression levels of Krt14 and Krt18 (data not shown) and a significant fluctuation in the number of cytokeratin-expressing cells ranging from 40 to 70% were observed.
Gene_expression (expression) of Krt14
4) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.06 Pain Relevance 0
As visualized by IF-staining, the G-2 cell pattern of cytokeratin expression was reproduced in G-2 cell derived clones (Figure S1A–B; shown as example for clones G-2C9 and G-2C11), although according to qPCR analysis the relative levels of Krt14 and Krt18 gene expression varied markedly between clones (Figure S1C–D).
Gene_expression (levels) of Krt14
5) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.14 Pain Relevance 0
In early passages the majority of the G-2 cells expressed both Krt14 (Figure 2G) and Krt18 intermediate filament proteins (Figure 2H); however the usual co-polymerization partner of Krt14, the Krt5 protein, was not detectable by a specific antibody (data not shown).
Gene_expression (expressed) of Krt14 in filament
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
In this respect, it is likely that the pronounced co-expression of Krt14 and Krt8/18 proteins in G-2 culture, but not in G-2 tumors, is attributed to selection in cell culture for a pro-proliferative function of Krt14.
Gene_expression (expression) of Krt14 associated with cancer
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.63 Pain Relevance 0
As visualized by IF-staining, the G-2 cell pattern of cytokeratin expression was reproduced in G-2 cell derived clones (Figure S1A–B; shown as example for clones G-2C9 and G-2C11), although according to qPCR analysis the relative levels of Krt14 and Krt18 gene expression varied markedly between clones (Figure S1C–D).
Gene_expression (expression) of Krt14
8) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.14 Pain Relevance 0
In subsequent passages slight variations in the individual expression levels of Krt14 and Krt18 (data not shown) and a significant fluctuation in the number of cytokeratin-expressing cells ranging from 40 to 70% were observed.
Gene_expression (levels) of Krt14
9) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.06 Pain Relevance 0
In this respect, it is likely that the pronounced co-expression of Krt14 and Krt8/18 proteins in G-2 culture, but not in G-2 tumors, is attributed to selection in cell culture for a pro-proliferative function of Krt14.
Gene_expression (-) of Krt14 associated with cancer
10) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.63 Pain Relevance 0
Compared to K5CrePR1, K14CrePR1 exhibits both less RU486-independent and RU486-induced Cre activity, perhaps because K14 is only expressed in a subset of K5 positive basal cells (see Figure 1B).
Gene_expression (expressed) of K14 in basal cells
11) Confidence 0.45 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2815352 Disease Relevance 0.07 Pain Relevance 0
While K14CrePR1 is less active than K5CrePR1, this may be reflective of fewer K14 positive than K5 positive tracheal basal cells, however, the tissue distribution and tracheal activity of K14 directed Cre activity is similar to what was previously reported with K14CreERT after induction with systemic tamoxifen 5, 18, 19 and is consistent with the K14 expression observed in the murine trachea.
Gene_expression (expression) of K14 in trachea
12) Confidence 0.45 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2815352 Disease Relevance 0.06 Pain Relevance 0
Interestingly, K14 expression appeared restricted to a subset of K5 positive cells in all three conducting airway epithelia (Figure 1B).
Gene_expression (expression) of K14
13) Confidence 0.45 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2815352 Disease Relevance 0 Pain Relevance 0
Immunofluorescence analysis of epidermal differentiation markers revealed appropriate expression of keratin 14 (K14) in the basal layer.
Gene_expression (expression) of K14 in basal layer
14) Confidence 0.39 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.85 Pain Relevance 0
Interestingly, Keratin 14-positive layer of the IFE was markedly expanded in both iK5-TERT mice and iK5-TERTci mice, although Ki-67+ cells were mostly confined in the basal monolayer (Figure 3E).
Gene_expression (expanded) of Keratin 14
15) Confidence 0.39 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.16 Pain Relevance 0.04
We report here that transgenic expression of NGF under control of the K14 keratin promoter can rescue some elements of the peripheral nervous system and restore normal growth and viability to ngf-/- mice.
Gene_expression (expression) of K14 keratin promoter in peripheral nervous system associated with targeted disruption and peripheral nervous system
16) Confidence 0.14 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15010204 Disease Relevance 0.41 Pain Relevance 0.13
Strikingly, when 3 day old spheres were transferred to 3D collagen, ductal structures were formed (Fig. 2B) that expressed CK 14 (Fig. 2C).
Gene_expression (expressed) of CK 14
17) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2329592 Disease Relevance 0 Pain Relevance 0
Previously, we showed that both the ICP0 and ICP4 promoter regions of HSV-1 become transiently enriched in the permissive histone mark acetyl H3 K9,K14 when sodium butyrate (NaB) is used as reactivation stimuli in mice latent with the efficiently reactivating 17Syn+strain of HSV-1 [19], [22], [30].
Gene_expression (enriched) of K14 associated with cold sores and sprains and strains
18) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.76 Pain Relevance 0.04
However, this perinatal lethality can be rescued by transgenic expression of NGF under the K14 keratin promoter, which restores the sensory and sympathetic neuronal populations [12].
Gene_expression (expression) of K14 keratin promoter in neuronal associated with targeted disruption and nerve growth factor
19) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.19 Pain Relevance 0.54
Cytokeratin (CK) 13 was detected in all epithelial cells whereas CK14 expression was limited to basal cells.
Gene_expression (expression) of CK14 in basal cells
20) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695612 Disease Relevance 0.14 Pain Relevance 0.03

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