INT117121

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 17
Disease Relevance 4.92
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa8) protein folding (Hspa8) cytosol (Hspa8)
intracellular (Hspa8) protein complex (Hspa8) response to stress (Hspa8)
Anatomy Link Frequency
brain 3
spermatids 2
plasma 1
livers 1
Hspa8 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 4 99.36 Very High Very High Very High
Paracetamol 30 98.64 Very High Very High Very High
Spinal cord 11 96.00 Very High Very High Very High
midbrain 88 95.32 Very High Very High Very High
Hippocampus 44 94.92 High High
cerebral cortex 22 94.40 High High
ischemia 24 86.28 High High
unmyelinated 7 81.80 Quite High
Demyelination 10 51.72 Quite High
hypoalgesia 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Shock 172 100.00 Very High Very High Very High
Stress 149 99.04 Very High Very High Very High
Atherosclerosis 117 98.48 Very High Very High Very High
Schizophrenia 11 96.56 Very High Very High Very High
Apoptosis 29 87.12 High High
Cv Unclassified Under Development 14 86.28 High High
Infarction 11 85.16 High High
Disease 125 84.96 Quite High
Toxicity 20 84.12 Quite High
Cv General 4 Under Development 11 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCR products of five heat-shock proteins (HSP70-1, HSP70-2, HSP70-3, Hsc70 and HSC70t) were produced in-house and added to the library, to produce a final total of 950 unique gene PCR products.


Gene_expression (products) of Hsc70 associated with shock
1) Confidence 0.65 Published 2001 Journal Genome Biol Section Body Doc Link PMC31483 Disease Relevance 0.18 Pain Relevance 0
Data that corroborate the inducible and constitutive expression of Hspa1a (Hsp70) and Hspa8 (Hsc70), respectively, has been shown by western blot of rat brain regions [91].
Gene_expression (expression) of Hspa8 in brain
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.20
Hspa8 and Hspabp are both ubiquitously expressed at high levels, suggesting Hspa8 is usually stably holding client proteins in an ADP-bound state.
Gene_expression (expressed) of Hspa8
3) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.03
Hspa8 is similarly expressed in all regions and both conditions while Hspa1a is expressed in all regions only after heat shock.
Gene_expression (expressed) of Hspa8 associated with shock
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.10 Pain Relevance 0.27
Data that corroborate the inducible and constitutive expression of Hspa1a (Hsp70) and Hspa8 (Hsc70), respectively, has been shown by western blot of rat brain regions [91].
Gene_expression (expression) of Hsc70 in brain
5) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.23
We examined changes in survival ratio, plasma APAP level and alanine aminotransferase (ALT) activity, and hepatic reduced glutathione (GSH), HSP25, HSP60, HSC70 and HSP70i levels following treatment of mice with APAP (500 mg/kg, p.o.).
Gene_expression (levels) of HSC70 in plasma associated with paracetamol
6) Confidence 0.60 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.32 Pain Relevance 0.92
The classic Heat Shock Cognate 70 genes are all expressed at high levels with the exception Hspa1l, which is reported to be specifically expressed in spermatids [33].
Neg (exception) Gene_expression (expressed) of Cognate 70 in spermatids associated with shock
7) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.86 Pain Relevance 0.08
Hspa8 (Hsc70) is considered to be the essential ‘housekeeping’ member of the 70 kD family which explains its high level of expression (reviewed in [37]).


Gene_expression (expression) of Hsc70
8) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.62 Pain Relevance 0.07
One well-studied functional cluster of genes involved in the folding of cytosolic proteins includes Hspa8, a variety of DnaJs, nucleotide exchange factors Bag1 and Hspbp1 (releasing Hspa8 of ADP), and Hspabp, a stabilizing factor for ADP-bound Hspa8.
Gene_expression (bound) of Hspa8
9) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.03
One well-studied functional cluster of genes involved in the folding of cytosolic proteins includes Hspa8, a variety of DnaJs, nucleotide exchange factors Bag1 and Hspbp1 (releasing Hspa8 of ADP), and Hspabp, a stabilizing factor for ADP-bound Hspa8.
Gene_expression (bound) of Hspa8
10) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.08 Pain Relevance 0.03
However, among the 35 genes that are uniformly highly expressed are several essential house-keeping genes such as Hsc70, BiP, Hsp90, calreticulin, and calnexin.
Gene_expression (expressed) of Hsc70
11) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.08 Pain Relevance 0
The classic Heat Shock Cognate 70 genes are all expressed at high levels with the exception Hspa1l, which is reported to be specifically expressed in spermatids [33].
Gene_expression (expressed) of Cognate 70 in spermatids associated with shock
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.86 Pain Relevance 0.08
These two genes represent the inducible forms of Hsp70, while a related chaperone that is constitutively expressed, Hsc70 (heat-shock cognate 70 stress protein), is present at normal levels in these mice (Hunt et al., 2004).
Gene_expression (expressed) of Hsc70 associated with stress and shock
13) Confidence 0.41 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.33 Pain Relevance 0.07
The aim of the present study was to assess the contribution of the level of expression of heat shock protein 25 (HSP25), 60 (HSP60), 70 (HSC70) and 70i (HSP70i) in mouse livers after a lethal dose of acetaminophen (APAP) to their survival.
Gene_expression (expression) of HSC70 in livers associated with paracetamol and shock
14) Confidence 0.40 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.31 Pain Relevance 0.68
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Gene_expression (production) of HSPA8 associated with chemokine and shock
15) Confidence 0.37 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.42 Pain Relevance 0.05
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Gene_expression (production) of heat shock 70 kDa protein 8 associated with chemokine and shock
16) Confidence 0.37 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.42 Pain Relevance 0.05
For example, the inducible Hsp70 (Hspa1a) is present at extremely low levels in brain, whereas the constitutively expressed Hsp90, Hsc70 an Hsp60 are easily detected [90].
Gene_expression (expressed) of Hsc70 in brain
17) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.06 Pain Relevance 0.15

General Comments

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