INT117122

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa8) protein folding (Hspa8) cytosol (Hspa8)
intracellular (Hspa8) protein complex (Hspa8) response to stress (Hspa8)
Anatomy Link Frequency
brain 4
plasma 2
Hspa8 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 15 99.04 Very High Very High Very High
cerebral cortex 4 89.60 High High
Hippocampus 8 88.24 High High
midbrain 16 87.20 High High
Spinal cord 2 86.08 High High
Inflammation 2 25.00 Low Low
medulla 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Hsan 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 30 88.20 High High
Injury 2 78.40 Quite High
Clinical Trials And Case Reports 2 50.00 Quite Low
INFLAMMATION 2 25.00 Low Low
Necrosis 1 25.00 Low Low
Disease 20 5.00 Very Low Very Low Very Low
Stress 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data that corroborate the inducible and constitutive expression of Hspa1a (Hsp70) and Hspa8 (Hsc70), respectively, has been shown by western blot of rat brain regions [91].
Positive_regulation (inducible) of Gene_expression (expression) of Hspa8 in brain
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.20
Data that corroborate the inducible and constitutive expression of Hspa1a (Hsp70) and Hspa8 (Hsc70), respectively, has been shown by western blot of rat brain regions [91].
Positive_regulation (inducible) of Gene_expression (expression) of Hsc70 in brain
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.23
We examined changes in survival ratio, plasma APAP level and alanine aminotransferase (ALT) activity, and hepatic reduced glutathione (GSH), HSP25, HSP60, HSC70 and HSP70i levels following treatment of mice with APAP (500 mg/kg, p.o.).
Spec (examined) Positive_regulation (following) of Gene_expression (levels) of HSC70 in plasma associated with paracetamol
3) Confidence 0.36 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.32 Pain Relevance 0.98

General Comments

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