INT117145

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.67
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1)
Anatomy Link Frequency
HFL1 4
macrophage 2
bone marrow 2
bands 2
bladder 2
Thbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 53 100.00 Very High Very High Very High
chemokine 11 100.00 Very High Very High Very High
Bioavailability 4 80.24 Quite High
Pain 2 68.68 Quite High
Paracetamol 2 68.32 Quite High
addiction 1 50.00 Quite Low
cytokine 27 26.76 Quite Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 59 100.00 Very High Very High Very High
Cancer 590 99.44 Very High Very High Very High
Adhesions 10 99.36 Very High Very High Very High
Malignant Neoplastic Disease 13 98.80 Very High Very High Very High
Melanoma 41 97.80 Very High Very High Very High
Leukemia 31 96.40 Very High Very High Very High
Reprotox - General 1 14 95.88 Very High Very High Very High
Bladder Cancer 93 94.56 High High
Esophageal Cancer 2 91.32 High High
Glioblastoma 2 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second hypothesis is that TSP-1 depletion limits the contribution of TSP-1 to TGF-?
Negative_regulation (limits) of Gene_expression (depletion) of TSP-1
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
Densitometric quantitation of TSP-1 bands from three independent experiments showed that adding NEM before shear reduced TSP-1 protein depletion during shear by approximately 50% (data not shown).
Negative_regulation (reduced) of Gene_expression (depletion) of TSP-1 protein in bands
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess production of the endogenous angiogenesis inhibitor thrombospondin-1 and prevents tumor growth.
Negative_regulation (suppresses) of Gene_expression (production) of thrombospondin-1 associated with inflammation and cancer
3) Confidence 0.31 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1800345 Disease Relevance 1.20 Pain Relevance 0.22
Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and malignant progression in melanoma [101].
Negative_regulation (reduced) of Gene_expression (expression) of thrombospondin-1 associated with malignant neoplastic disease and melanoma
4) Confidence 0.24 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.09 Pain Relevance 0.07
Microvessel and thrombospondin-1 distribution in UPII-SV40T bladder
Negative_regulation (Microvessel) of Gene_expression (distribution) of thrombospondin-1 in bladder
5) Confidence 0.24 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.81 Pain Relevance 0
However, the TSP-1 overexpressing construct inhibited growth of DU-145 xenografts in Balb/c mice.
Negative_regulation (inhibited) of Gene_expression (overexpressing) of TSP-1
6) Confidence 0.24 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.53 Pain Relevance 0.04
In the present study, we monitored the expression of RGS1, CC3, THBS1, vWF, MADH7, and a novel gene encoding a secreted protein in irradiated Jurkat, TK6, HeLa, and HFL1 cells.
Negative_regulation (monitored) of Gene_expression (expression) of THBS1 in HFL1
7) Confidence 0.24 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
Real-time reverse transcription-polymerase chain reaction analysis revealed that V-PYRRO/NO administration suppressed the expression of inflammation-related genes such as macrophage inflammatory protein-2, CXC chemokine, thrombospondin-1, intracellular adhesion molecular-1, and interleukin-6.
Negative_regulation (suppressed) of Gene_expression (expression) of thrombospondin-1 in macrophage associated with chemokine, inflammation and adhesions
8) Confidence 0.13 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.75 Pain Relevance 0.25
In the present study, we monitored the expression of RGS1, CC3, THBS1, vWF, MADH7, and a novel gene encoding a secreted protein in irradiated Jurkat, TK6, HeLa, and HFL1 cells.
Negative_regulation (monitored) of in HeLa Gene_expression (expression) of THBS1 in HFL1
9) Confidence 0.08 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
In the present study, we monitored the expression of RGS1, CC3, THBS1, vWF, MADH7, and a novel gene encoding a secreted protein in irradiated Jurkat, TK6, HeLa, and HFL1 cells.
Negative_regulation (monitored) of in TK6 Gene_expression (expression) of THBS1 in HFL1
10) Confidence 0.08 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
“Angiogenesis switch” in leukemia is documented by increased bone marrow MVD (Figures 2(a) and 2(b)), increased expression of HIF-1, multiple proangiogenic factors (VEGF, bFGF, angiopoietin-2), soluble VEGFR, and decreased expression of endogenous angiogenesis inhibitors, such as thrombospondin-1 [11, 12].
Negative_regulation (decreased) of Gene_expression (expression) of thrombospondin-1 in bone marrow associated with leukemia
11) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.06 Pain Relevance 0

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