INT117147

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 15.33
Pain Relevance 6.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl2) extracellular region (Cxcl2)
Anatomy Link Frequency
macrophage 10
liver 2
pleural cavity 2
neutrophils 2
Cxcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 414 100.00 Very High Very High Very High
cytokine 363 100.00 Very High Very High Very High
chemokine 118 100.00 Very High Very High Very High
agonist 27 99.70 Very High Very High Very High
Dextromethorphan 14 99.68 Very High Very High Very High
ischemia 58 97.24 Very High Very High Very High
Inflammatory response 92 96.12 Very High Very High Very High
Morphine 9 91.64 High High
cINOD 1 83.32 Quite High
antagonist 13 78.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 493 100.00 Very High Very High Very High
Necrosis 106 99.70 Very High Very High Very High
Lung Injury 32 99.68 Very High Very High Very High
Sprains And Strains 55 99.16 Very High Very High Very High
Corneal Disease 24 98.84 Very High Very High Very High
Adhesions 17 98.04 Very High Very High Very High
Infection 146 97.48 Very High Very High Very High
Cv Unclassified Under Development 58 97.24 Very High Very High Very High
Injury 320 97.08 Very High Very High Very High
Lung Cancer 21 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
polyclonal antibody, the protein expression of MIP-2 and KC significantly decreased in the IL-1?
Negative_regulation (decreased) of Gene_expression (expression) of MIP-2
1) Confidence 0.55 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.06 Pain Relevance 0.26
polyclonal antibody, the severity of corneal disease was significantly reduced, and this was accompanied by a reduction in corneal PMN cells, bacterial load, and MIP-2 mRNA and protein expression.
Negative_regulation (reduction) of Gene_expression (expression) of MIP-2 associated with corneal disease
2) Confidence 0.55 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.35 Pain Relevance 0.24
Selective antagonism of the C3a receptor significantly attenuated production of MIP-2 and KC, whereas C5a receptor antagonism and prevention of membrane attack complex (MAC) formation did not have a significant effect on MIP-2 and KC production [34].
Negative_regulation (attenuated) of Gene_expression (production) of MIP-2
3) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.71 Pain Relevance 0.25
It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.
Negative_regulation (inhibits) of Gene_expression (production) of MIP-2 in macrophage associated with chemokine, inflammation and disease
4) Confidence 0.41 Published 2001 Journal Mediators Inflamm Section Abstract Doc Link PMC1781695 Disease Relevance 0.91 Pain Relevance 0.46
The results showed that MIP-2 protein expression levels were reduced significantly (p=0.000) one, three, five, and seven days post-infection in the MIP-2 treated group compared to the infected group and that the KC protein expression levels decreased slightly (p>0.05).
Negative_regulation (reduced) of Gene_expression (expression) of MIP-2 protein associated with infection
5) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.49 Pain Relevance 0.28
The peak expression levels of MIP-2, KC, and IL-1?
Negative_regulation (levels) of Gene_expression (expression) of MIP-2
6) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.90 Pain Relevance 0.36
It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.
Negative_regulation (inhibits) of Gene_expression (production) of inflammatory protein-2 in macrophage associated with chemokine, inflammation and disease
7) Confidence 0.36 Published 2001 Journal Mediators Inflamm Section Abstract Doc Link PMC1781695 Disease Relevance 0.91 Pain Relevance 0.46
Real-time reverse transcription-polymerase chain reaction analysis revealed that V-PYRRO/NO administration suppressed the expression of inflammation-related genes such as macrophage inflammatory protein-2, CXC chemokine, thrombospondin-1, intracellular adhesion molecular-1, and interleukin-6.
Negative_regulation (suppressed) of Gene_expression (expression) of macrophage inflammatory protein-2 in macrophage associated with chemokine, inflammation and adhesions
8) Confidence 0.29 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.74 Pain Relevance 0.25
Further, estrogen at physiological levels reduces IL-6, and MIP-2 production in many cell types, including macrophages [27,31,32].
Negative_regulation (reduces) of Gene_expression (production) of MIP-2 in macrophages
9) Confidence 0.28 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.45 Pain Relevance 0.12
However, our study indicated that during the late phase of hepatic IR, cholinergic agonists significantly inhibited CXC chemokine production (i.e., MIP-2), which did not correlate with neutrophil infiltration and the liver IR injury.
Negative_regulation (inhibited) of Gene_expression (production) of MIP-2 in liver associated with chemokine, injury and agonist
10) Confidence 0.24 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 1.10 Pain Relevance 0.58
Deltorphin-Dvariant, but not DADLE or DPDPE, dose-dependently reduced both TNFalpha and MIP-2 production.
Negative_regulation (reduced) of Gene_expression (production) of MIP-2
11) Confidence 0.22 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The data show that delta2- but not delta1-opioid agonists suppress LPS-induced p38 MAPK activation and expression of TNFalpha and MIP-2.


Neg (not) Negative_regulation (suppress) of Gene_expression (expression) of MIP-2
12) Confidence 0.22 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0
Indeed the hAFSC injected ATN mice showed a decrease in JE, M-CSF, MIP-2, MPC-5 and KC expression, when versus the ATN mice treated with vehicle solution (PBS) or just ATN induction (Figure 8B and Table S2).
Negative_regulation (decrease) of Gene_expression (expression) of MIP-2 associated with necrosis
13) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 1.02 Pain Relevance 0.47
PPADS prevented neither the production of MIP-2, nor the changes in W/D weight ratio and permeability index following ventilation.
Negative_regulation (prevented) of Gene_expression (production) of MIP-2
14) Confidence 0.19 Published 2008 Journal Respir Res Section Body Doc Link PMC2627837 Disease Relevance 0.82 Pain Relevance 0.15
Strain differences in V2O5-induced inflammatory chemokine (KC, MIP-2, MCP-1) expression
Negative_regulation (chemokine) of Gene_expression (expression) of MIP-2 associated with chemokine, inflammation and sprains and strains
15) Confidence 0.16 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 1.20 Pain Relevance 0.34
Such an event in the pleural cavity was preceded by increased levels of KC and MIP-2 at 1 and 2 h.
Negative_regulation (preceded) of Gene_expression (levels) of MIP-2 in pleural cavity
16) Confidence 0.15 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.65 Pain Relevance 0.25
Real-time RT-PCR analysis revealed that DM administration suppressed the expression of a variety of inflammation-related genes such as macrophage inflammatory protein-2, CXC chemokine, thrombospondin-1, intercellular adhesion molecular-1 and interleukin-6.
Negative_regulation (suppressed) of Gene_expression (expression) of inflammatory protein-2 in macrophage associated with chemokine, inflammation, dextromethorphan and adhesions
17) Confidence 0.12 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15627475 Disease Relevance 1.06 Pain Relevance 0.79
The decreased synthesis of MIP-2 and inflammatory cytokines coupled with the decreased release of galectin-3 result in reduced migration of neutrophils to the site of infection, thereby increasing susceptibility to S. pneumoniae infection after morphine treatment.
Negative_regulation (decreased) of Gene_expression (synthesis) of MIP-2 in neutrophils associated with inflammation, infection, morphine and cytokine
18) Confidence 0.09 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15611267 Disease Relevance 0.77 Pain Relevance 0.87
These results suggest that a vaccine targeting sialidase effectively suppresses P. acnes-induced production of the pro-inflammatory cytokine MIP-2 in the mice.


Negative_regulation (suppresses) of Gene_expression (production) of MIP-2 associated with inflammation and cytokine
19) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 1.19 Pain Relevance 0.44

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