INT117186

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 24.19
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
blood 2
regulatory T cells 2
bone marrow 1
brain 1
neural 1
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1105 100.00 Very High Very High Very High
Inflammation 246 100.00 Very High Very High Very High
opiate 2 99.98 Very High Very High Very High
agonist 56 99.44 Very High Very High Very High
adenocard 56 99.00 Very High Very High Very High
rheumatoid arthritis 227 98.16 Very High Very High Very High
Arthritis 39 98.00 Very High Very High Very High
antagonist 184 97.84 Very High Very High Very High
Opioid 17 92.64 High High
drug abuse 3 92.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 285 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 384 99.96 Very High Very High Very High
Cancer 1954 99.86 Very High Very High Very High
Colon Cancer 147 99.80 Very High Very High Very High
Hematologic Neoplasms 7 99.72 Very High Very High Very High
Myocardial Infarction 5 99.68 Very High Very High Very High
Leukemia 73 99.64 Very High Very High Very High
Muscular Dystrophy 210 99.20 Very High Very High Very High
Breast Cancer 245 99.06 Very High Very High Very High
Carcinoma 63 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mRNA expression up to 10-fold, and selectively increase cell-surface CXCR4
Positive_regulation (increase) of CXCR4
1) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.12 Pain Relevance 0.32
within tumors may also increase CXCR4 expression.

13.

Spec (may) Positive_regulation (increase) of CXCR4 associated with cancer
2) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.05 Pain Relevance 0
Recently, it has been demonstrated that the overexpression of HER2/neu in breast cancer enhances the metastatic potential through the upregulation of CXCR4, providing a link between CXCR4 and HER2/neu in tumor progression and metastasis [86].
Positive_regulation (upregulation) of CXCR4 associated with cancer, breast cancer and metastasis
3) Confidence 0.53 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.42 Pain Relevance 0.03
Stromal cells within bone marrow microenvironment constitutively secrete CXCL12 and the activation of CXCR4 induces leukemia cell migration to the marrow microenvironment, providing growth and drug resistance signals.
Positive_regulation (activation) of CXCR4 in bone marrow associated with leukemia
4) Confidence 0.53 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.53 Pain Relevance 0.03
of the CXCR4 gene lead to aberrant
Positive_regulation (lead) of CXCR4
5) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.43 Pain Relevance 0.08
A2b adenosine receptors on human colorectal carcinoma cells to upregulate CXCR4
Positive_regulation (upregulate) of CXCR4 associated with adenocard and colon cancer
6) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.07 Pain Relevance 0.33
Application of the CXCR4 receptor agonist SDF-1alpha (50 nM) further increased the FRET signal from tagged CXCR4 receptors, an effect that was inhibited by the CXCR4 antagonist AMD3100.
Positive_regulation (increased) of CXCR4 associated with antagonist and agonist
7) Confidence 0.50 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15014135 Disease Relevance 0.18 Pain Relevance 0.46
This paper will review recently identified mechanisms of opiate-induced CXCR4 impairment in neurons and introduce results from pilot studies in human brain tissue, which highlight the role of the protein ferritin heavy chain in HIV neuropathology in patients with history of drug abuse.
Positive_regulation (induced) of CXCR4 in brain associated with drug abuse, acquired immune deficiency syndrome or hiv infection and opiate
8) Confidence 0.49 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20627326 Disease Relevance 0.37 Pain Relevance 0.36
Of these patients, 8 were categorized in the first group as exhibiting a percentage of CD133+CXCR4+CD34- cells localized above the threshold level for their corresponding age (mean age±SD: 9.17±3.01), while 11 patients were in the second ground, showing values below the regression line (mean age±SD: 10.91±3.04).
Positive_regulation (percentage) of CXCR4
9) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.35 Pain Relevance 0
These data suggest that the levels of circulating CD133+CXCR4+CD34- cells could be a biomarker for DMD.
Positive_regulation (circulating) of CXCR4 associated with muscular dystrophy
10) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.84 Pain Relevance 0
The

existence of a mechanism of 15dPGJ2-induced CXCR4 downregulation

Positive_regulation (induced) of CXCR4
11) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.44 Pain Relevance 0.23
This increase in cell-surface CXCR4 enables the
Positive_regulation (increase) of CXCR4
12) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.08 Pain Relevance 0.31
and indeed components of the extracellular matrix itself, can upregulate CXCR4
Positive_regulation (upregulate) of CXCR4 in extracellular matrix
13) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.24 Pain Relevance 0
In a subgroup of 19 DMD patients after 24 months of follow-up, increased levels of CD133+CXCR4+CD34- cells was shown to be associated with a phenotype characterised by slower disease progression.
Positive_regulation (increased) of CXCR4 associated with muscular dystrophy and disease progression
14) Confidence 0.46 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2377332 Disease Relevance 0.77 Pain Relevance 0
In patients with AMI, a significant increase in CD34+/CXCR4+, CD117+, c-met+ and CD34/CD117+ stem cell number the in peripheral blood was demonstrated with parallel increase in mRNA expression for early cardiac, muscle and endothelial markers in peripheral blood mononuclear cells.
Positive_regulation (increase) of CXCR4 in mononuclear cells associated with myocardial infarction
15) Confidence 0.44 Published 2005 Journal Folia Histochem. Cytobiol. Section Abstract Doc Link 16382890 Disease Relevance 1.00 Pain Relevance 0.32
Indeed, in hematological malignancies, tumor cells use CXCR4 for dissemination and progression of the disease, because interactions of CXCR4 with its ligand are critical for hematopoietic cells trafficking and homing to lymphatic tissues [132].
Positive_regulation (use) of CXCR4 in hematopoietic cells associated with cancer, hematologic neoplasms and disease
16) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.46 Pain Relevance 0.09
More recently, several studies proposed that CXCR4-dependent activation of ERK1/2 was mediated by transactivation of tyrosine kinase receptors.
Positive_regulation (activation) of CXCR4-dependent
17) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.60 Pain Relevance 0.10
A similar mechanism was also demonstrated in breast cancer cell lines, showing that estrogen-dependent proliferation involves the synthesis of CXCL12 (identified as estradiol-dependent gene), that causes an autocrine stimulation of CXCR4 and the subsequent activation of c-Src that, in turn, induces a ligand-independent activation of EGFR and ERK1/2 phosphorylation [41].
Positive_regulation (stimulation) of CXCR4 associated with breast cancer
18) Confidence 0.35 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.85 Pain Relevance 0.20
It was shown that in leukemia cells, several growth and survival factors from the tumor microenvironment, including CXCR4 activation, induce PI3K activation.
Positive_regulation (activation) of CXCR4 associated with leukemia and cancer
19) Confidence 0.35 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.37 Pain Relevance 0
The transactivation of HER2/neu through CXCL12 stimulation of CXCR4 and Src activation cells was also demonstrated, in breast and prostate cancers [41–43].

3.

Positive_regulation (stimulation) of CXCR4 associated with prostate cancer
20) Confidence 0.35 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.88 Pain Relevance 0.22

General Comments

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