INT117189

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 24.27
Pain Relevance 5.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
stromal cell 1
immune cells 1
OC 316 1
germ cell 1
OC 314 1
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1264 100.00 Very High Very High Very High
cytokine 47 100.00 Very High Very High Very High
Kinase C 36 99.80 Very High Very High Very High
antagonist 358 99.46 Very High Very High Very High
Arthritis 30 97.94 Very High Very High Very High
Central nervous system 38 97.48 Very High Very High Very High
agonist 72 96.40 Very High Very High Very High
opiate 3 95.60 Very High Very High Very High
rheumatoid arthritis 46 95.28 Very High Very High Very High
imagery 92 92.08 High High
Disease Link Frequency Relevance Heat
Disease 194 99.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 972 99.58 Very High Very High Very High
Glioma 32 99.52 Very High Very High Very High
Cancer 2550 98.96 Very High Very High Very High
Ovarian Cancer 794 98.60 Very High Very High Very High
Infection 252 98.60 Very High Very High Very High
Hematologic Neoplasms 9 98.36 Very High Very High Very High
Nasopharynx Cancer 2 97.96 Very High Very High Very High
Arthritis 32 97.94 Very High Very High Very High
Immunodeficiency 21 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CXCR4 gene is constitutively expressed, and CXCR4 protein has been
CXCR4 protein Binding (been) of
1) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.26 Pain Relevance 0.07
Until recently, CXCR4 was considered to be the only receptor for CXCL12, but
CXCR4 Binding (recently) of
2) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.17 Pain Relevance 0.07
CXCR4 has been
CXCR4 Binding (been) of
3) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.86 Pain Relevance 0.04
Regulation of CXCR4 receptor dimerization by the chemokine SDF-1alpha and the HIV-1 coat protein gp120: a fluorescence resonance energy transfer (FRET) study.
CXCR4 Binding (dimerization) of associated with chemokine and acquired immune deficiency syndrome or hiv infection
4) Confidence 0.37 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15014135 Disease Relevance 0.28 Pain Relevance 0.34
FRET analysis of tagged hCD4 constructs demonstrated that there was significant association of hCD4 and CXCR4, as well as hCD4 dimerization.
CXCR4 Binding (association) of
5) Confidence 0.37 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15014135 Disease Relevance 0.07 Pain Relevance 0.34
Alterations of CXCL12/CXCR4 signaling are implicated in different neuropathologies, including the neurological complications of HIV infection.
CXCR4 Binding (Alterations) of associated with acquired immune deficiency syndrome or hiv infection and infection
6) Confidence 0.37 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20627326 Disease Relevance 0.19 Pain Relevance 0.32
In three other ovarian cancer cell lines (OC 314, OC 315, OC 316), it was demonstrated that CXCL12/CXCR4 interaction induces a dose-dependent cell proliferation through ERK1/2 and Akt activation that was dependent on EGFR phosphorylation caused by a mechanism involving the activity of the cytosolic tyrosine kinase c-Src [40].
CXCR4 Binding (interaction) of in OC 316 associated with ovarian cancer
7) Confidence 0.36 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.52 Pain Relevance 0.09
Different studies demonstrated that in mouse germ cell migration and survival requires the CXCL12/CXCR4 interaction [106, 107].
CXCR4 Binding (interaction) of in germ cell
8) Confidence 0.36 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.36 Pain Relevance 0.03
In normal cells, upon activation, CXCR4 dimerizes and transduces several intracellular signals (Figure 2).
CXCR4 Binding (dimerizes) of
9) Confidence 0.36 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.84 Pain Relevance 0.11
Indeed, in hematological malignancies, tumor cells use CXCR4 for dissemination and progression of the disease, because interactions of CXCR4 with its ligand are critical for hematopoietic cells trafficking and homing to lymphatic tissues [132].
CXCR4 Binding (interactions) of in hematopoietic cells associated with cancer, hematologic neoplasms and disease
10) Confidence 0.36 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.50 Pain Relevance 0.06
groups to be a ligand for LESTR/fusin/CD184, and the name CXCR4 was proposed [8, 9].
LESTR Binding (ligand) of
11) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.33 Pain Relevance 0.13
groups to be a ligand for LESTR/fusin/CD184, and the name CXCR4 was proposed [8, 9].
fusin Binding (ligand) of
12) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.33 Pain Relevance 0.13
groups to be a ligand for LESTR/fusin/CD184, and the name CXCR4 was proposed [8, 9].
CD184 Binding (ligand) of
13) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.33 Pain Relevance 0.13
the ER, and CXCR4 protein which binds to CXCL12 is also retained in the ER,
CXCR4 protein Binding (binds) of
14) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.41 Pain Relevance 0
To understand the molecular basis for these differences, we tagged the rat CXCR4 receptor with enhanced cyan (ECFP) and yellow (EYFP) derivatives of the green fluorescent protein and investigated CXCR4 receptor dimerization in human embryonic kidney (HEK)-tsA201 cells using fluorescence resonance energy transfer (FRET).
CXCR4 Binding (dimerization) of in embryonic kidney
15) Confidence 0.35 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15014135 Disease Relevance 0.25 Pain Relevance 0.27
Indeed, the widespread metastatic lesions suggest the expression of chemokine receptor CXCR4 which has been associated with a high rate of metastatic potential of human nasopharyngeal carcinoma [6].
CXCR4 Binding (associated) of associated with chemokine and nasopharynx cancer
16) Confidence 0.35 Published 2008 Journal The Open AIDS Journal Section Body Doc Link PMC2556196 Disease Relevance 2.04 Pain Relevance 0.09
The fluorescence lifetime images are pseudo-colored to facilitate recognition of areas with increased interaction between CXCR4 and PKC?
CXCR4 Binding (interaction) of associated with kinase c
17) Confidence 0.34 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.42 Pain Relevance 0.36
In the last years, several molecules able to target CXCR4 or CXCL12 have been developed to interfere with tumor growth, including pharmacological inhibitors, antagonists, and specific antibodies.
CXCR4 Binding (target) of associated with cancer and antagonist
18) Confidence 0.28 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2798669 Disease Relevance 0.72 Pain Relevance 0.29
Although for many years the interaction between CXCR4 and CXCL12 was thought to be unique, more recently, it was reported that CXCL12 binds also to another receptor, named CXCR7 [34].
CXCR4 Binding (interaction) of
19) Confidence 0.28 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.27 Pain Relevance 0.18
In particular, this notion is further supported by the different mechanisms resulting from CXCR4 inhibition: (a) the reversal of stromal cell interactions responsible of tumor cell survival; (b) the blockade of proangiogenic activity of CXCL12 and the reduction of the dissemination and migration ability of tumor cells; (c) the blockade of tumor growth through autocrine/paracrine signaling mediated by CXCL12/CXCR4 interaction; (d) the mobilization of tumor cells from tissues to increase their sensitivity to conventional chemoterapeutic agents.
CXCR4 Binding (interaction) of in stromal cell associated with cancer
20) Confidence 0.27 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.78 Pain Relevance 0.10

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