INT117197

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 8.30
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Zmat3) RNA binding (Zmat3) nucleus (Zmat3)
intracellular (Zmat3)
Anatomy Link Frequency
PBL 2
lymph nodes 1
liver 1
bone marrow 1
spleen 1
Zmat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 1 98.28 Very High Very High Very High
Enkephalin 1 97.80 Very High Very High Very High
MU agonist 4 96.28 Very High Very High Very High
cINOD 6 94.96 High High
anesthesia 91 87.48 High High
ketamine 45 86.68 High High
opioid receptor 4 85.88 High High
Demyelination 20 76.48 Quite High
agonist 3 74.88 Quite High
Central nervous system 30 74.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 719 100.00 Very High Very High Very High
Stomach Cancer 4 99.86 Very High Very High Very High
Apoptosis 3 99.50 Very High Very High Very High
Sprains And Strains 62 99.00 Very High Very High Very High
Cytomegalovirus Infection 3 98.84 Very High Very High Very High
Paralysis 4 93.36 High High
INFLAMMATION 3 91.68 High High
Cancer 1 90.00 High High
Bordatella Infection 1 87.68 High High
Exsanguination 45 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Supersensitization was observed in cells expressing wild-type Galpha, but this was lost on PTX treatment.
Gene_expression (expressing) of wild-type Galpha
1) Confidence 0.05 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15014136 Disease Relevance 0.16 Pain Relevance 0.81
To examine the presence of circulating anti-hPLAP antibodies in serum of wild-type rats that had previously received cells from hPLAP-tg rats, wild-type and transgenic peripheral blood cells were incubated for 30 min on ice with 10 ?
Gene_expression (rats) of wild-type in blood cells associated with targeted disruption
2) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.24 Pain Relevance 0
To test whether wild-type recipients develop antibodies against hPLAP after injection of cells from transgenic donor rats of the same strain, we intraperitoneally or subcutaneously injected wild-type F344 rats with PBL from hPLAP-tg rats three times with an 11-day interval between the injections.
Gene_expression (rats) of wild-type in PBL associated with targeted disruption and sprains and strains
3) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.72 Pain Relevance 0
Immune response of wild-type rats after syngeneic transplantation of cells from hPLAP-tg rats
Gene_expression (rats) of wild-type
4) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.28 Pain Relevance 0
To examine the development of antibody production against transgenic cells, we repeatedly exposed wild-type rats to PBL from hPLAP-tg donors.
Gene_expression (rats) of wild-type associated with targeted disruption
5) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.33 Pain Relevance 0.21
However, as shown in Fig. 2C, repeated intraperitoneal injection of transgenic PBL induced an antibody response in wild-type rats.
Gene_expression (rats) of wild-type in PBL associated with targeted disruption
6) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.77 Pain Relevance 0
l undiluted serum from naïve wild-type rats or from wild-type rats that had received transgenic PBL earlier.
Gene_expression (rats) of wild-type associated with targeted disruption
7) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.39 Pain Relevance 0.08
However, histological analysis of lung, liver, spleen, lymph nodes, and bone failed to show any evidence of hPLAP-expressing cells from transgenic donors in the wild-type recipients, suggesting that it was not possible to syngeneically transplant cells from transgenic donors into wild-type rats (Fig. 1).
Gene_expression (expressing) of wild-type in liver associated with targeted disruption
8) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.43 Pain Relevance 0
To test a cellular immune response to hPLAP in wild-type rats, we performed mixed lymphocyte reaction protocols.
Gene_expression (rats) of wild-type in lymphocyte
9) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.82 Pain Relevance 0
Transplantation of transgenic blood and bone marrow cells into wild-type recipients
Gene_expression (recipients) of wild-type in blood associated with targeted disruption
10) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.44 Pain Relevance 0.11
Non-immune mouse IgG1 (MOPC-21, Sigma) and cell suspensions from wild-type rats were used as negative controls.
Gene_expression (rats) of wild-type
11) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.05 Pain Relevance 0
Fig. 3A–C shows that in irradiated wild-type rats transplanted with hPLAP-tg bone marrow [WT (hPLAP-BMT)] all hematopoietic cells are of donor origin, and stably express hPLAP, 4 weeks post-transplantation.
Gene_expression (rats) of wild-type in hematopoietic cells
12) Confidence 0.04 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.25 Pain Relevance 0.06
We established two independent WTC.DMY-dmy lines, expressing each Mrs2 wild-type cDNA under the control of a cytomegalovirus (CMV) promoter (Figure S2A), and found that all dmy/dmy transgenic rats exhibited a completely normal phenotype, with no paralysis of the hind limbs.
Gene_expression (expressing) of wild-type in hind limbs associated with targeted disruption, cytomegalovirus infection and paralysis
13) Confidence 0.02 Published 2011 Journal PLoS Genetics Section Body Doc Link PMC3017111 Disease Relevance 0.85 Pain Relevance 0.13
However, histological analysis of lung, liver, spleen, lymph nodes, and bone failed to show any evidence of hPLAP-expressing cells from transgenic donors in the wild-type recipients, suggesting that it was not possible to syngeneically transplant cells from transgenic donors into wild-type rats (Fig. 1).
Gene_expression (expressing) of wild-type in lung associated with targeted disruption
14) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.43 Pain Relevance 0
However, histological analysis of lung, liver, spleen, lymph nodes, and bone failed to show any evidence of hPLAP-expressing cells from transgenic donors in the wild-type recipients, suggesting that it was not possible to syngeneically transplant cells from transgenic donors into wild-type rats (Fig. 1).
Gene_expression (expressing) of wild-type in lymph nodes associated with targeted disruption
15) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.43 Pain Relevance 0
However, histological analysis of lung, liver, spleen, lymph nodes, and bone failed to show any evidence of hPLAP-expressing cells from transgenic donors in the wild-type recipients, suggesting that it was not possible to syngeneically transplant cells from transgenic donors into wild-type rats (Fig. 1).
Gene_expression (expressing) of wild-type in spleen associated with targeted disruption
16) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.43 Pain Relevance 0
Transplantation of transgenic blood and bone marrow cells into wild-type recipients
Gene_expression (recipients) of wild-type in bone marrow associated with targeted disruption
17) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC1899491 Disease Relevance 0.44 Pain Relevance 0.11
Apoptosis in gastric cancer cells expressing wild-type p53 is induced through up-regulation of bax and down-regulation of bcl-2 and that regulation of the bax-bcl-2 heterodimer may be a major target of NSAIDs.
Gene_expression (expressing) of wild-type p53 associated with cinod, apoptosis and stomach cancer
18) Confidence 0.01 Published 2008 Journal Cancer Invest. Section Abstract Doc Link 18798056 Disease Relevance 0.81 Pain Relevance 0.53
Interestingly, the single particle EM structures of the GluA2 wild-type and GluA2 L504Y were significantly different (Fig. 7a, b).
Gene_expression (wild-type) of wild-type
19) Confidence 0.01 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0

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