INT117203

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.40
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, IL6) aging (IL1B, IL6) extracellular region (IL1B, IL6)
cytosol (IL1B) signal transduction (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
blood 1
internal 1
IL1B (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 35 100.00 Very High Very High Very High
Inflammatory marker 3 98.82 Very High Very High Very High
cytokine 20 93.60 High High
sSRI 1 91.04 High High
antidepressant 3 89.52 High High
chemokine 13 70.24 Quite High
Inflammation 12 68.40 Quite High
Inflammatory mediators 1 51.68 Quite High
Snapping jaw 2 50.00 Quite Low
metalloproteinase 5 34.00 Quite Low
Disease Link Frequency Relevance Heat
Depression 38 100.00 Very High Very High Very High
INFLAMMATION 16 98.66 Very High Very High Very High
Major Depressive Disorder 25 90.24 High High
Acute-phase Reaction 1 89.04 High High
Fatigue 2 72.84 Quite High
Schizophrenia 50 59.16 Quite High
Temporomandibular Joint Syndrome 2 58.32 Quite High
Adhesions 1 52.20 Quite High
Metabolic Syndrome 2 45.08 Quite Low
Vascular Dementia 1 33.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: It has been shown that the presence of IL-1beta and IL-6 in synovial fluid may be indicators of possible unsuccessful treatment following arthrocentesis for internal derangement of the TMJ.


IL-1beta Binding (presence) of IL-6 in internal
1) Confidence 0.20 Published 2004 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 15015157 Disease Relevance 0.06 Pain Relevance 0
A recent meta-analysis on inflammatory markers in depressed patients has confirmed a consistent positive association between depression and IL-6, and IL-1 and the acute phase protein CRP levels in peripheral blood [40].
IL-1 Binding (association) of IL-6 in blood associated with depression and inflammatory marker
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820097 Disease Relevance 1.34 Pain Relevance 0.51

General Comments

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