INT117205

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 9.40
Pain Relevance 4.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
neuronal 1
hypothalamus 1
thyroid 1
liver 1
vesicle 1
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 159 99.84 Very High Very High Very High
fluoxetine 11 99.36 Very High Very High Very High
Inflammation 175 95.84 Very High Very High Very High
Arthritis 330 93.60 High High
Hippocampus 19 92.80 High High
Potency 14 91.00 High High
antagonist 43 88.80 High High
Neuropeptide 5 88.12 High High
rheumatoid arthritis 69 87.12 High High
Pain 12 87.12 High High
Disease Link Frequency Relevance Heat
Stress 35 100.00 Very High Very High Very High
Targeted Disruption 59 99.20 Very High Very High Very High
Cancer 155 98.96 Very High Very High Very High
Diabetes Mellitus 147 98.54 Very High Very High Very High
Weight Loss 2 97.24 Very High Very High Very High
Inflammatory Bowel Disease 4 96.40 Very High Very High Very High
INFLAMMATION 191 93.76 High High
Experimental Arthritis 196 93.60 High High
Thyroid Disease 6 92.80 High High
Systemic Lupus Erythematosus 21 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten years later a second receptor was identified in mice, rats and humans, and was named ER?
Transcription (named) of ER
1) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.27 Pain Relevance 0.37
Here, we chose to investigate the relative contribution of ER?
Spec (investigate) Transcription (contribution) of ER
2) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.37 Pain Relevance 0.65
Next, we chose to further study the role of the different ERs in mice in vivo using well-described ER?
Transcription (described) of ER
3) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.79 Pain Relevance 0.32
titration study in vivo provides evidence that ERB-79 at 3 mg/kg subcutaneous does not demonstrate significant ER?
Neg (not) Transcription (demonstrate) of ER
4) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.85 Pain Relevance 0.40
ERalpha mRNA was present at all stages and highest at estrus.
Transcription (present) of ERalpha
5) Confidence 0.53 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15936815 Disease Relevance 0.49 Pain Relevance 0.69
In fact, in the present in vivo study, the mRNA levels of the truncated ER?
Transcription (levels) of ER
6) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.57 Pain Relevance 0
In summary, the present data demonstrate that ER?
Transcription (demonstrate) of ER
7) Confidence 0.47 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.33 Pain Relevance 0.07
These studies were conducted in non-neuronal cells, however, western blot, immunohistochemical and surface biotinylated protein studies have confirmed the presence of both ER?
Transcription (presence) of ER in neuronal
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0 Pain Relevance 0.08
As a precautionary measure metabolic profiling of new ER?
Transcription (profiling) of ER
9) Confidence 0.41 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.32 Pain Relevance 0.16
Protein expression of intracellular Ca2+ regulatory proteins, ER stress markers and ?
Transcription (markers) of ER associated with stress
10) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.21 Pain Relevance 0
Furthermore, each of the evaluation items, with the exception of ESR and CRP, used to calculate DAS28-ESR, CDAI and SDAI progressively improved during the TCZ treatment.
Neg (exception) Transcription (exception) of ESR
11) Confidence 0.22 Published 2010 Journal Mod Rheumatol Section Body Doc Link PMC2999727 Disease Relevance 0.40 Pain Relevance 0.06
In control, when the animals were injected with 200 mM N-Methyl-D-glucamine dithiocarbamate sodium salt and 200 mM ferrous sulfate (FeSO4) complex without a prior LPS injection, characteristic line of ESR spectrum was not detected in the liver (Fig. 3A).
Neg (not) Transcription (detected) of ESR in liver
12) Confidence 0.15 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 0 Pain Relevance 0
By contrast, the C96Y PNDM-associated mutant proinsulin is localized to the expanded ER and is not transported from the ER to the Golgi and packaged into secretory granules
Neg (not) Transcription (transported) of ER associated with diabetes mellitus
13) Confidence 0.11 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.60 Pain Relevance 0
We previously reported that hydralazine induces in vitro and in vivo, demethylation and transcriptional reactivation at the mRNA and protein levels of the ER, RAR?
Transcription (levels) of ER
14) Confidence 0.10 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1131894 Disease Relevance 0.63 Pain Relevance 0
We found that fluoxetine also significantly reduced the expression of estrogen receptor (ER)beta1 mRNA by 4-fold in both the hypothalamus and the telencephalon and ERalpha mRNA by 1.7-fold in the telencephalon.
Transcription (expression) of estrogen receptor in hypothalamus associated with fluoxetine
15) Confidence 0.09 Published 2008 Journal Physiol. Genomics Section Abstract Doc Link 18765858 Disease Relevance 0 Pain Relevance 0.91
The ratio of the mRNA levels of ER?
Transcription (levels) of ER
16) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
mRNA is in agreement with a previous study where the ER mRNA levels were shown to be similar in OVX controls and after ICI or TAM treatment [35].
Transcription (levels) of ER
17) Confidence 0.06 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.16 Pain Relevance 0
In this study we examined the effects of these compounds on the mRNA levels of the GH receptor/GH binding protein, IGF-I, ER?
Transcription (levels) of ER
18) Confidence 0.05 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.20 Pain Relevance 0.16
We studied the effects on mRNA levels of the growth hormone (GH) receptor, insulin-like growth factor-I (IGF-I), ER?
Transcription (levels) of ER
19) Confidence 0.05 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC156658 Disease Relevance 0.08 Pain Relevance 0.04
In addition, ER-GFP-C was also detected in the cytosolic fraction with a distribution similar to that of the endogenous TcCRT (Figure 5B), thus demonstrating that the TcCRT-C is sufficient to sustain retrotranslocation.
Transcription (detected) of ER-GFP
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0

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