INT117212

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 5.83
Pain Relevance 8.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Hcn2) plasma membrane (Hcn2) transmembrane transport (Hcn2)
Anatomy Link Frequency
neurons 5
spinal 1
HCN-2 1
granulosa cells 1
bladder 1
Hcn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 88 100.00 Very High Very High Very High
hCN2 62 100.00 Very High Very High Very High
c fibre 20 99.68 Very High Very High Very High
Trigeminal ganglion neurons 4 99.40 Very High Very High Very High
qutenza 7 98.64 Very High Very High Very High
Calcitonin gene-related peptide 2 98.38 Very High Very High Very High
sodium channel 8 97.32 Very High Very High Very High
Inflammation 14 96.88 Very High Very High Very High
spinal dorsal horn 12 96.52 Very High Very High Very High
dorsal root ganglion 6 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 45 100.00 Very High Very High Very High
Diabetes Mellitus 21 99.74 Very High Very High Very High
Ganglion Cysts 33 99.38 Very High Very High Very High
Nociception 12 99.36 Very High Very High Very High
INFLAMMATION 10 96.88 Very High Very High Very High
Pain 4 87.48 High High
Nervous System Injury 2 86.96 High High
Diabetic Neuropathy 3 79.44 Quite High
Targeted Disruption 1 25.44 Quite Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In double labelling immunohistochemical studies, we have also shown that HCN2 widely co-localizes with calcitonin gene-related peptide, but is almost completely segregated from isolectin-B4 binding, indicating that HCN2 is primarily expressed in peptidergic nociceptive primary afferents.
Gene_expression (expressed) of HCN2 associated with nociception, calcitonin gene-related peptide and hcn2
1) Confidence 0.78 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15016091 Disease Relevance 0.17 Pain Relevance 0.73
The expression of HCN2 in central terminals of peptidergic primary afferents was also verified with electron microscopy.
Gene_expression (expression) of HCN2 associated with hcn2
2) Confidence 0.78 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15016091 Disease Relevance 0.17 Pain Relevance 0.72
In addition, the number of retrogradely labeled neurons from the dura expressing HCN1 and HCN2 was significantly increased to 247% (HCN1) and 171% (HCN2), three days after inflammation.
Gene_expression (expressing) of HCN2 in neurons associated with inflammation, hcn1 and hcn2
3) Confidence 0.75 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.60 Pain Relevance 1.31
HCN1 and HCN2 channel immunoreactivity was observed on the membranes of medium- to large-sized trigeminal ganglion neurons with 76% and 85% of HCN1 and HCN2 expressing neurons also containing the 200 kDa neurofilament protein (associated with myelinated fibers).
Gene_expression (expressing) of HCN2 in neurons associated with ganglion cysts, hcn1, trigeminal ganglion neurons and hcn2
4) Confidence 0.75 Published 2009 Journal Neuroscience Section Abstract Doc Link 19409968 Disease Relevance 0.52 Pain Relevance 0.78
Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.
Gene_expression (expression) of HCN2 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2
5) Confidence 0.75 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.02 Pain Relevance 0.75
Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.
Gene_expression (expression) of HCN2 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2
6) Confidence 0.75 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.02 Pain Relevance 0.73
In the sham NG, HCN1, HCN3, and HCN4 were expressed in the A-fiber neurons; and HCN2, HCN3, and HCN4 were expressed in the C-fiber neurons.
Gene_expression (expressed) of HCN2 in neurons associated with ganglion cysts, c fibre, hcn1 and hcn2
7) Confidence 0.75 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.01 Pain Relevance 0.70
In dye-labeled bladder afferent neurons, HCN-2-positive cells were found in approximately 60% of neurons, and HCN-2 was expressed in both small- and medium-sized neurons with a higher ratio (expression ratio: 61% and 50% of neurons, respectively) compared with unidentified DRG neurons, in which the HCN expression ratio was 47% and 21% of small- and medium-sized cells, respectively.
Gene_expression (expressed) of HCN-2 in bladder associated with dorsal root ganglion
8) Confidence 0.74 Published 2006 Journal Brain Res. Section Abstract Doc Link 16979600 Disease Relevance 0.50 Pain Relevance 0.70
At the mRNA level, HCN2 and HCN4 are highly expressed in the nuclei compared with HCN1 (Ludwig et al., 1998; Monteggia et al., 2000; Santoro et al., 2000; Chen et al., 2005), whereas immunohistochemistry suggests the presence of protein for all three subunits (Notomi & Shigemoto, 2004).
Gene_expression (expressed) of HCN2 associated with hcn1 and hcn2
9) Confidence 0.50 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.16
We have previously demonstrated that hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 (HCN2) is expressed by terminals of peptidergic nociceptive primary afferents in laminae I-IIo of the rat spinal dorsal horn.
Gene_expression (expressed) of HCN2 in spinal associated with nociception, spinal dorsal horn and hcn2
10) Confidence 0.49 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16987220 Disease Relevance 0.17 Pain Relevance 0.50
In the data presented in this report, HCN1 and HCN2 had minimal variation through the aging process, with HCN1 only exhibiting declining levels in the oocytes during reproductive aging.
Gene_expression (exhibiting) of HCN2 in oocytes associated with aging, hcn1 and hcn2
11) Confidence 0.46 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.40 Pain Relevance 0.20
For HCN1, HCN2, and HCN3, the proteins were found in oocytes and in the granulosa cells of primary, preantral, and antral follicles.
Gene_expression (found) of HCN2 in granulosa cells associated with hcn1 and hcn2
12) Confidence 0.46 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.41
HCN-1 and HCN-2 channel isoform immunoreactivity was detected in 82.6% and 88.3%, respectively, and binding of IB4 in 29.4% of all neurons.
Gene_expression (detected) of HCN-2 in HCN-2
13) Confidence 0.17 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18218331 Disease Relevance 0.24 Pain Relevance 0.51

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