INT117213

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.05
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga4)
Anatomy Link Frequency
spinal 1
neurons 1
mesenteric artery 1
primary sensory neurons 1
Cnga4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
hCN2 28 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
HCN1 2 100.00 Very High Very High Very High
spinal dorsal horn 12 96.52 Very High Very High Very High
trigeminal ganglion 4 93.60 High High
Neurotransmitter 1 87.92 High High
substance P 5 75.00 Quite High
Spinal cord 3 71.60 Quite High
dorsal rhizotomy 2 69.12 Quite High
Migraine 4 67.36 Quite High
Disease Link Frequency Relevance Heat
Nociception 11 98.84 Very High Very High Very High
Ganglion Cysts 4 93.60 High High
Headache 4 67.36 Quite High
Pain 3 57.00 Quite High
Targeted Disruption 1 25.44 Quite Low
Migraine Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyperpolarization-activated cyclic nucleotide-gated cation channel proteins (HCN1-4), which are potentially able to modulate membrane excitability, are abundantly expressed by neurons in spinal dorsal root ganglia (DRG).
Gene_expression (expressed) of cyclic nucleotide-gated cation channel in neurons associated with hcn1
1) Confidence 0.50 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15016091 Disease Relevance 0.07 Pain Relevance 0.36
Expression of hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 in axon terminals of peptidergic nociceptive primary sensory neurons in the superficial spinal dorsal horn of rats.
Gene_expression (Expression) of cyclic nucleotide-gated cation channel in primary sensory neurons associated with nociception, pain and spinal dorsal horn
2) Confidence 0.50 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 15016091 Disease Relevance 0.15 Pain Relevance 0.59
The CNGA4 and B1 subunit mRNAs were detected in cerebral arteries and CNGA2 also in the mesenteric artery.
Gene_expression (detected) of CNGA4 in mesenteric artery
3) Confidence 0.44 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16808996 Disease Relevance 0.66 Pain Relevance 0.68
We have previously demonstrated that hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 (HCN2) is expressed by terminals of peptidergic nociceptive primary afferents in laminae I-IIo of the rat spinal dorsal horn.
Gene_expression (expressed) of cyclic nucleotide-gated cation channel in spinal associated with nociception, spinal dorsal horn and hcn2
4) Confidence 0.18 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16987220 Disease Relevance 0.17 Pain Relevance 0.50

General Comments

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