INT117219

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.66
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOD2) plasma membrane (NOD2) enzyme binding (NOD2)
cytoplasm (NOD2)
Anatomy Link Frequency
bowel 1
Paneth cells 1
NOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 21 99.58 Very High Very High Very High
Inflammation 79 98.76 Very High Very High Very High
agonist 9 91.56 High High
cytokine 70 82.88 Quite High
Inflammatory mediators 3 81.04 Quite High
anesthesia 1 77.20 Quite High
antagonist 4 73.84 Quite High
ischemia 1 64.32 Quite High
Fibrositis 97 62.40 Quite High
Inflammatory response 12 58.80 Quite High
Disease Link Frequency Relevance Heat
Crohn's Disease 12 99.66 Very High Very High Very High
Disease 43 99.58 Very High Very High Very High
INFLAMMATION 83 98.76 Very High Very High Very High
Familial Mediterranean Fever 25 92.52 High High
Endotoxemia 5 89.28 High High
Syndrome 10 89.24 High High
Infection 123 87.12 High High
Bacterial Respiratory Disease 8 86.88 High High
Injury 16 86.60 High High
Death 14 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We thus hypothesize that alternative splicing of the two novel isoforms contributes to the upregulation of NOD2 protein levels observed under inflammatory conditions and the high constitutive expression in distinct cell types, i.e. monocytic cells and, possibly, Paneth cells.
Positive_regulation (upregulation) of NOD2 in Paneth cells associated with inflammation
1) Confidence 0.69 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.38 Pain Relevance 0.17
Since the activation of Nod1 and Nod2 leads to the activation of NF?
Positive_regulation (activation) of Nod2
2) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.05
To determine to what extent the lipopolysaccharide-induced TNF-alpha production capacity in vivo and ex vivo is determined by polymorphisms in toll-like receptor-4 (TLR4), the TNF-alpha promoter region and Nod2, we screened for two TLR4 polymorphisms, a Nod2 polymorphism and the TNF-alpha promoter polymorphisms.
Positive_regulation (toll-like) of Nod2
3) Confidence 0.47 Published 2004 Journal Cytokine Section Abstract Doc Link 15016407 Disease Relevance 0.45 Pain Relevance 0.14
B phosphorylation upon PGN-ECndss treatment as well as IL-6 inducibility after UV exposure suggest a functional Nod1/Nod2-initiated NF?
Positive_regulation (functional) of Nod2
4) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.68 Pain Relevance 0.27
B phosphorylation upon PGN-ECndss treatment as well as IL-6 inducibility after UV exposure suggest a functional Nod1/Nod2-initiated NF?
Positive_regulation (suggest) of Nod2
5) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.68 Pain Relevance 0.27
An obvious paradoxon is created by the fact that "loss-of function" variants in NOD2 have been genetically associated with a higher risk for the development of Crohn disease, whereas higher levels of NOD2 protein have been detected by several groups independent from the respective NOD2 genotype.
Positive_regulation (levels) of NOD2 associated with crohn's disease
6) Confidence 0.46 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.44 Pain Relevance 0.10
This situation would be similar to the role of NOD2 in Crohn's disease, in which wild type NOD2, also a member of the NLR family [40], inhibits TLR2 (toll-like receptor-2) activation by peptidoglycan, while mutated NOD2 fails to inhibit TLR2, leading to chronic inflammation in the bowel [41].
Positive_regulation (activation) of NOD2 in bowel associated with inflammation, crohn's disease and disease
7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.95 Pain Relevance 0.23
In addition, CARD15, also known as NOD2, was upregulated in infected cells.
Positive_regulation (upregulated) of NOD2
8) Confidence 0.18 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.25 Pain Relevance 0
The nucleotide-binding oligomerization domain 2 (NOD2) is activated by muramyl dipeptide (MDP), which is another degradation product of the peptidoglycan produced by lysozyme and other (bacterial) peptidoglycan hydrolases.
Positive_regulation (activated) of NOD2
9) Confidence 0.10 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.36 Pain Relevance 0.06
Activation of NOD1 and NOD2 results in the translocation of NF-?
Positive_regulation (Activation) of NOD2
10) Confidence 0.10 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.47 Pain Relevance 0.04

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