INT117222

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 6
Speculated 3
Reported most in Body
Documents 80
Total Number 83
Disease Relevance 51.60
Pain Relevance 12.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
monocytes 14
T cells 8
macrophages 6
ileum 4
intestinal epithelium 4
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1668 100.00 Very High Very High Very High
cytokine 1186 100.00 Very High Very High Very High
Angina 17 100.00 Very High Very High Very High
Inflammatory marker 11 100.00 Very High Very High Very High
rheumatoid arthritis 573 99.96 Very High Very High Very High
spinal inflammation 129 99.90 Very High Very High Very High
Arthritis 479 99.80 Very High Very High Very High
endometriosis 84 99.74 Very High Very High Very High
Osteoarthritis 11 97.16 Very High Very High Very High
chemokine 198 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1961 100.00 Very High Very High Very High
Cancer 139 100.00 Very High Very High Very High
Necrosis 116 100.00 Very High Very High Very High
Pressure And Volume Under Development 34 100.00 Very High Very High Very High
Stable Angina Pectoris 9 100.00 Very High Very High Very High
Rheumatoid Arthritis 884 99.96 Very High Very High Very High
Pancreatitis 5 99.96 Very High Very High Very High
Low Back Pain 129 99.90 Very High Very High Very High
Coronary Artery Disease 36 99.84 Very High Very High Very High
Meningoencephalitis 11 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mild AP, TLR4 expression increased on the first day of admission and then continued to decline for several days.
Positive_regulation (increased) of Gene_expression (expression) of TLR4 associated with pancreatitis
1) Confidence 0.70 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.69 Pain Relevance 0.08
Toll-like receptor 4 expressions on peripheral blood monocytes were enhanced in coronary artery disease even in patients with low C-reactive protein.
Positive_regulation (enhanced) of Gene_expression (expressions) of Toll-like receptor 4 in coronary artery associated with coronary artery disease
2) Confidence 0.69 Published 2006 Journal Life Sci. Section Title Doc Link 17045300 Disease Relevance 1.27 Pain Relevance 0.19
Moreover, TLR4 expression levels in stable angina pectoris (SAP) patients were elevated compared with those in non-CAD subjects (P < 0.05), and those in acute coronary syndrome patients were higher than SAP patients even in low-hsCRP subjects (P < 0.01).
Positive_regulation (elevated) of Gene_expression (expression) of TLR4 associated with stable angina pectoris, acute coronary syndrome, angina and coronary artery disease
3) Confidence 0.69 Published 2006 Journal Life Sci. Section Abstract Doc Link 17045300 Disease Relevance 1.60 Pain Relevance 0.30
We propose that the sterile inflammation process, which occurs in the pelvic cavity upon endometriosis, is able to enhance the epithelial TLR4 expression and thus activate the known downstream signalling cascade.
Positive_regulation (enhance) of Gene_expression (expression) of TLR4 in cavity associated with endometriosis and inflammation
4) Confidence 0.66 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.21 Pain Relevance 0.31
Following microbial insult, cholangiocytes decrease let-7i expression and consequently upregulate TLR4 expression via translational suppression in infected cells, which contributes to epithelial immune responses to microbial infection [37].
Positive_regulation (upregulate) of Gene_expression (expression) of TLR4 associated with infection
5) Confidence 0.65 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.10 Pain Relevance 0.22
Stimulation of alveolar macrophages and monocytes with LPS, however, augmented the expression of TLR4 on both alveolar macrophages and monocytes already after 10 minutes (Figure 4B).
Positive_regulation (augmented) of Gene_expression (expression) of TLR4 in monocytes
6) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.17 Pain Relevance 0
Furthermore, priming with PAF directly led to enhanced LPS-induced IL-8 secretion, thus showing the functional effect of increased TLR4 expression.
Positive_regulation (increased) of Gene_expression (expression) of TLR4
7) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.43 Pain Relevance 0.03
As seen in Figure 4, there appeared to be increased TLR4 expression in cells treated with PAF as compared to unstimulated control.
Positive_regulation (increased) of Gene_expression (expression) of TLR4
8) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.13 Pain Relevance 0.07
Furthermore, in cells over-expressing PAFR, treatment with PAF resulted in a dose-dependent activation of a TLR4 promoter reporter construct, and in an in vivo model, luminal perfusion of an ileal loop with PAF resulted in enhanced intestinal TLR4 gene expression.
Positive_regulation (enhanced) of Gene_expression (expression) of TLR4 gene
9) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.80 Pain Relevance 0.15
We show that perfusion of PAF in the lumen of the ileum in this experimental model results in an increase of TLR4 expression in mucosal scrapings that is not seen either in the mucosa of sham-perfused animals or in the mucosa outside of the perfused loop either in the PAF-perfused or sham perfused animals.
Positive_regulation (increase) of Gene_expression (expression) of TLR4 in ileum
10) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.44 Pain Relevance 0
We have found that in various human and rodent tissue culture models of intestinal epithelium, stimulation with PAF results in an upregulation of TLR4 expression, correlating with an enhanced TLR4 ligand-induced inflammatory gene expression.
Positive_regulation (upregulation) of Gene_expression (expression) of TLR4 in intestinal epithelium associated with inflammation
11) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.05 Pain Relevance 0.18
Following stimulation of cells with cPAF, we observed a dose- and time-dependent increase in TLR4 gene expression using Real Time PCR analysis (Figure 2a and b).
Positive_regulation (increase) of Gene_expression (expression) of TLR4 gene
12) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.28 Pain Relevance 0.05
More directly, we have recently shown in an established neonatal rat model and a novel neonatal murine model of NEC, that bacteria and TLR4 play a significant role in experimental NEC, likely via an interaction of intraluminal bacteria and aberrantly overexpressed TLR4 in enterocytes [16].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TLR4 in enterocytes associated with neonatal necrotizing enterocolitis
13) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.71 Pain Relevance 0.12
Platelet-activating factor induced TLR4 expression is inhibited by STAT3 and NF?
Positive_regulation (induced) of Gene_expression (expression) of TLR4 in Platelet
14) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Expression of TLR2 and TLR4 has been shown to be increased in the synovial tissue of RA patients compared with healthy donors or osteoarthritis samples [108], [109].
Positive_regulation (increased) of Gene_expression (Expression) of TLR4 associated with osteoarthritis and arthritis
15) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.92 Pain Relevance 0.38
The combined measurement of serum hsCRP and the TLR4 expression on peripheral blood monocytes, especially among low-hsCRP subjects, may become a new coronary risk marker.
Positive_regulation (measurement) of Gene_expression (expression) of TLR4 in monocytes
16) Confidence 0.49 Published 2006 Journal Life Sci. Section Abstract Doc Link 17045300 Disease Relevance 1.43 Pain Relevance 0.26
To determine to what extent the lipopolysaccharide-induced TNF-alpha production capacity in vivo and ex vivo is determined by polymorphisms in toll-like receptor-4 (TLR4), the TNF-alpha promoter region and Nod2, we screened for two TLR4 polymorphisms, a Nod2 polymorphism and the TNF-alpha promoter polymorphisms.
Positive_regulation (screened) of Gene_expression (polymorphism) of TLR4
17) Confidence 0.49 Published 2004 Journal Cytokine Section Abstract Doc Link 15016407 Disease Relevance 0.49 Pain Relevance 0.15
healthy controls could be explained by increased expression of TLR4 receptors
Positive_regulation (increased) of Gene_expression (expression) of TLR4
18) Confidence 0.49 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.30 Pain Relevance 0.48
We test the hypothesis that the pro-inflammatory signaling indirectly stimulates the transcriptional activation of endotoxin receptor (TLR4); which quantitatively is expressed by the linear function (HP,R), (4b).
Positive_regulation (activation) of Gene_expression (expressed) of TLR4 associated with inflammation
19) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.23 Pain Relevance 0.19
These results suggest that TLR-4 expression on ascites cells of a macrophage lineage is essential for ascites cells to produce TNF-alpha in relation to OK-432 stimulation and for subsequent positive clinical responses in locoregional immunotherapy using OK-432 for malignant ascites from gastric cancer.
Positive_regulation (essential) of Gene_expression (expression) of TLR-4 in macrophage associated with malignant neoplastic disease, pressure and volume under development and stomach cancer
20) Confidence 0.48 Published 2006 Journal Anticancer Res. Section Abstract Doc Link 17094388 Disease Relevance 1.77 Pain Relevance 0.08

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