INT117223
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In mild AP, TLR4 expression increased on the first day of admission and then continued to decline for several days. | |||||||||||||||
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On the seventh day, TLR4 expression was almost normal compared with that of the normal control. | |||||||||||||||
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Alterations of Toll-like receptor 4 expression on peripheral blood monocytes during the early stage of human acute pancreatitis. | |||||||||||||||
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PBMCs were isolated, and TLR4 and CD14 expression on PBMCs was detected by flow cytometer. | |||||||||||||||
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We sought to study Toll-like receptor 4 (TLR4) expression on peripheral blood mononuclear cells (PBMCs) during the early stage of human acute pancreatitis (AP). | |||||||||||||||
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We sought to study Toll-like receptor 4 (TLR4) expression on peripheral blood mononuclear cells (PBMCs) during the early stage of human acute pancreatitis (AP). | |||||||||||||||
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We investigated whether the TLR4 expression levels on human peripheral blood monocytes were associated with serum hsCRP levels or the occurrence of coronary artery diseases (CAD). | |||||||||||||||
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The combined measurement of serum hsCRP and the TLR4 expression on peripheral blood monocytes, especially among low-hsCRP subjects, may become a new coronary risk marker. | |||||||||||||||
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Among the low-hsCRP subjects, the TLR4 expression levels were higher in CAD patients than in non-CAD subjects (P < 0.05, after being adjusted for other risk factors). | |||||||||||||||
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In conclusion, the TLR4 expression levels on peripheral blood monocytes in CAD patients were higher than those in non-CAD subjects and correlated with disease activity, even in low-hsCRP subjects. | |||||||||||||||
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Toll-like receptor 4 expressions on peripheral blood monocytes were enhanced in coronary artery disease even in patients with low C-reactive protein. | |||||||||||||||
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Moreover, TLR4 expression levels in stable angina pectoris (SAP) patients were elevated compared with those in non-CAD subjects (P < 0.05), and those in acute coronary syndrome patients were higher than SAP patients even in low-hsCRP subjects (P < 0.01). | |||||||||||||||
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Almost all therapeutic vaccine adjuvant approaches use ligands for one of the Toll-like receptors (TLR) expressed on DC. | |||||||||||||||
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Macrophages and dendritic cells (DCs) express numerous Toll-like receptors (TLRs) [10] and respond to microbial pathogens by producing type I interferons (IFN) and cytokines. | |||||||||||||||
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Recently, there is research effort to elucidate the unknown mechanism that drives the regulation of TLR4 expression [61] and research findings [62] support the potential role of pro-inflammatory cytokines to up-regulate the TLR expression. | |||||||||||||||
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Thus, the predominant expression of TLR4, observed in uterine tissues, might reflect the occurrence of sterile inflammation during the menstrual cycle. | |||||||||||||||
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We propose that the sterile inflammation process, which occurs in the pelvic cavity upon endometriosis, is able to enhance the epithelial TLR4 expression and thus activate the known downstream signalling cascade. | |||||||||||||||
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Co-immunostainings on menstrual effluents confirmed that CD14 positive dendritic cells and monocytes (figure 2K) as well as CD163 positive resident macrophages (figure 2L) expressed TLR4 protein. | |||||||||||||||
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In addition, we report the expression of TLR4 protein on immune cells such as monocytes and macrophages, in menstrual phase samples (figure 2J). | |||||||||||||||
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TLR3 and TLR4 expression is deregulated in peritoneal endometriosis | |||||||||||||||
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