INT117223

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 4
Speculated 12
Reported most in Abstract
Documents 348
Total Number 362
Disease Relevance 206.18
Pain Relevance 54.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
monocytes 34
macrophages 19
epithelial cells 13
alveolar macrophages 13
T cells 13
TLR4 (Homo sapiens)
TLR4 - T399I (1) TLR4 - D299G (1)
Pain Link Frequency Relevance Heat
agonist 2046 100.00 Very High Very High Very High
COX2 7 100.00 Very High Very High Very High
spinal inflammation 481 99.96 Very High Very High Very High
cytokine 4493 99.92 Very High Very High Very High
depression 15 99.92 Very High Very High Very High
tolerance 296 99.86 Very High Very High Very High
Arthritis 1465 99.84 Very High Very High Very High
Bile 188 99.84 Very High Very High Very High
endometriosis 758 99.78 Very High Very High Very High
addiction 51 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 620 100.00 Very High Very High Very High
Necrosis 454 100.00 Very High Very High Very High
Cirrhosis 2074 99.98 Very High Very High Very High
Obesity 607 99.98 Very High Very High Very High
Low Back Pain 481 99.96 Very High Very High Very High
Carcinoma 305 99.96 Very High Very High Very High
Biliary Liver Cirrhosis 136 99.96 Very High Very High Very High
Pancreatitis 30 99.96 Very High Very High Very High
Atherosclerosis 178 99.92 Very High Very High Very High
Coronary Artery Disease 93 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mild AP, TLR4 expression increased on the first day of admission and then continued to decline for several days.
Gene_expression (expression) of TLR4 associated with pancreatitis
1) Confidence 0.78 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.69 Pain Relevance 0.08
On the seventh day, TLR4 expression was almost normal compared with that of the normal control.
Gene_expression (expression) of TLR4
2) Confidence 0.78 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.66 Pain Relevance 0.08
Alterations of Toll-like receptor 4 expression on peripheral blood monocytes during the early stage of human acute pancreatitis.
Gene_expression (expression) of Toll-like receptor 4 in monocytes associated with pancreatitis
3) Confidence 0.78 Published 2007 Journal Dig. Dis. Sci. Section Title Doc Link 17415654 Disease Relevance 0.68 Pain Relevance 0.09
PBMCs were isolated, and TLR4 and CD14 expression on PBMCs was detected by flow cytometer.
Gene_expression (expression) of TLR4
4) Confidence 0.78 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.71 Pain Relevance 0.09
We sought to study Toll-like receptor 4 (TLR4) expression on peripheral blood mononuclear cells (PBMCs) during the early stage of human acute pancreatitis (AP).
Gene_expression (expression) of Toll-like receptor 4 in mononuclear cells associated with pancreatitis
5) Confidence 0.78 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.62 Pain Relevance 0.08
We sought to study Toll-like receptor 4 (TLR4) expression on peripheral blood mononuclear cells (PBMCs) during the early stage of human acute pancreatitis (AP).
Gene_expression (expression) of TLR4 in mononuclear cells associated with pancreatitis
6) Confidence 0.78 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.62 Pain Relevance 0.08
We investigated whether the TLR4 expression levels on human peripheral blood monocytes were associated with serum hsCRP levels or the occurrence of coronary artery diseases (CAD).
Gene_expression (expression) of TLR4 in blood associated with coronary artery disease
7) Confidence 0.77 Published 2006 Journal Life Sci. Section Abstract Doc Link 17045300 Disease Relevance 1.06 Pain Relevance 0.12
The combined measurement of serum hsCRP and the TLR4 expression on peripheral blood monocytes, especially among low-hsCRP subjects, may become a new coronary risk marker.
Gene_expression (expression) of TLR4 in monocytes
8) Confidence 0.77 Published 2006 Journal Life Sci. Section Abstract Doc Link 17045300 Disease Relevance 1.41 Pain Relevance 0.25
Among the low-hsCRP subjects, the TLR4 expression levels were higher in CAD patients than in non-CAD subjects (P < 0.05, after being adjusted for other risk factors).
Gene_expression (expression) of TLR4 associated with coronary artery disease
9) Confidence 0.77 Published 2006 Journal Life Sci. Section Abstract Doc Link 17045300 Disease Relevance 1.51 Pain Relevance 0.25
In conclusion, the TLR4 expression levels on peripheral blood monocytes in CAD patients were higher than those in non-CAD subjects and correlated with disease activity, even in low-hsCRP subjects.
Gene_expression (expression) of TLR4 in monocytes associated with coronary artery disease and disease
10) Confidence 0.77 Published 2006 Journal Life Sci. Section Abstract Doc Link 17045300 Disease Relevance 1.54 Pain Relevance 0.28
Toll-like receptor 4 expressions on peripheral blood monocytes were enhanced in coronary artery disease even in patients with low C-reactive protein.
Gene_expression (expressions) of Toll-like receptor 4 in coronary artery associated with coronary artery disease
11) Confidence 0.77 Published 2006 Journal Life Sci. Section Title Doc Link 17045300 Disease Relevance 1.14 Pain Relevance 0.18
Moreover, TLR4 expression levels in stable angina pectoris (SAP) patients were elevated compared with those in non-CAD subjects (P < 0.05), and those in acute coronary syndrome patients were higher than SAP patients even in low-hsCRP subjects (P < 0.01).
Gene_expression (expression) of TLR4 associated with stable angina pectoris, acute coronary syndrome, angina and coronary artery disease
12) Confidence 0.77 Published 2006 Journal Life Sci. Section Abstract Doc Link 17045300 Disease Relevance 1.57 Pain Relevance 0.29
Almost all therapeutic vaccine adjuvant approaches use ligands for one of the Toll-like receptors (TLR) expressed on DC.
Gene_expression (expressed) of Toll
13) Confidence 0.75 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.17 Pain Relevance 0.13
Macrophages and dendritic cells (DCs) express numerous Toll-like receptors (TLRs) [10] and respond to microbial pathogens by producing type I interferons (IFN) and cytokines.
Gene_expression (express) of Toll in dendritic cells associated with cytokine
14) Confidence 0.75 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.68 Pain Relevance 0.05
Recently, there is research effort to elucidate the unknown mechanism that drives the regulation of TLR4 expression [61] and research findings [62] support the potential role of pro-inflammatory cytokines to up-regulate the TLR expression.
Gene_expression (expression) of TLR4 associated with inflammation and cytokine
15) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.25 Pain Relevance 0.21
Thus, the predominant expression of TLR4, observed in uterine tissues, might reflect the occurrence of sterile inflammation during the menstrual cycle.
Gene_expression (expression) of TLR4 in uterine associated with inflammation
16) Confidence 0.74 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.44 Pain Relevance 0.10
We propose that the sterile inflammation process, which occurs in the pelvic cavity upon endometriosis, is able to enhance the epithelial TLR4 expression and thus activate the known downstream signalling cascade.
Gene_expression (expression) of TLR4 in cavity associated with endometriosis and inflammation
17) Confidence 0.74 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.20 Pain Relevance 0.31
Co-immunostainings on menstrual effluents confirmed that CD14 positive dendritic cells and monocytes (figure 2K) as well as CD163 positive resident macrophages (figure 2L) expressed TLR4 protein.
Gene_expression (expressed) of TLR4 protein in macrophages
18) Confidence 0.74 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.31 Pain Relevance 0.08
In addition, we report the expression of TLR4 protein on immune cells such as monocytes and macrophages, in menstrual phase samples (figure 2J).
Gene_expression (expression) of TLR4 protein in macrophages
19) Confidence 0.74 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.21 Pain Relevance 0.07
TLR3 and TLR4 expression is deregulated in peritoneal endometriosis
Gene_expression (expression) of TLR4 associated with endometriosis
20) Confidence 0.74 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.10 Pain Relevance 0.05

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