INT117232

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.34
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
cleavage 3
hip 1
cartilage 1
articular cartilage 1
urine 1
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
algogenic 2 100.00 Very High Very High Very High
Osteoarthritis 343 99.00 Very High Very High Very High
Pain 14 85.76 High High
Inflammation 44 70.92 Quite High
metalloproteinase 77 59.52 Quite High
Antihistamine 1 59.08 Quite High
Analgesic 2 58.44 Quite High
cva 1 51.40 Quite High
cytokine 43 50.48 Quite High
imagery 35 50.00 Quite Low
Disease Link Frequency Relevance Heat
Otitis Media 80 100.00 Very High Very High Very High
Common Cold 18 99.64 Very High Very High Very High
Otitis Media With Effusion 29 99.48 Very High Very High Very High
Osteoarthritis 356 99.00 Very High Very High Very High
Aseptic Necrosis Of Bone 1 97.96 Very High Very High Very High
Eye Disease 21 97.80 Very High Very High Very High
Hypertrophy 92 94.56 High High
Osteophyte 10 93.88 High High
Pharyngitis 19 93.76 High High
Bronchitis 1 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downregulation of collagen cleavage was not accompanied by significant changes in GAG release in explants cultured in the presence of 10 pg/ml PGE2 (Figure 2).
Localization (cleavage) of collagen in cleavage
1) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.48 Pain Relevance 0.29
The cartilage (triplicate cultures for each analytical point) was cultured for a total of 16 days and analyzed at day 16 for COL2A1 cleavage by collagenases and proteoglycan release.
Spec (analyzed) Localization (cleavage) of COL2A1 in cartilage
2) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.13 Pain Relevance 0.07
2 on the collagen degeneration in OA articular cartilage [3] and that PGE2 can suppress collagen cleavage.
Localization (cleavage) of collagen in cleavage associated with osteoarthritis
3) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.51 Pain Relevance 0.09
We observed an inverse relationship between PGE2 concentration and collagen cleavage activity in OA explant cultures that served as controls by plotting PGE2 concentration versus collagen cleavage in the control OA articular cartilage explants (Figure 1g).
Localization (concentration) of collagen in articular cartilage associated with osteoarthritis
4) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.46 Pain Relevance 0.23
The aim of the study was to present a ANFH of three young persons diagnosed too late that ended with implantation of total hip arthoplasty (THA).
Localization (present) of ANFH in hip
5) Confidence 0.68 Published 2010 Journal Chir Narzadow Ruchu Ortop Pol Section Abstract Doc Link 20695186 Disease Relevance 0.55 Pain Relevance 0.07
The benefit of finding a genetic association with specific genes is that we can begin to understand more about how the parasite triggers the development of ocular disease during embryogenesis and fetal development by examining what is known about the chronological expression and localization of COL2A1 and ABCA4 during development and after birth.
Localization (localization) of COL2A1 associated with eye disease
6) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.37 Pain Relevance 0.03
OME may be a precursor event initiating suppurate AOM but it can be the continuum of AOM as well.
Localization (initiating) of AOM associated with otitis media and otitis media with effusion
7) Confidence 0.52 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC1876255 Disease Relevance 1.55 Pain Relevance 0.12
Occasional algal blooms, comprised of blue-green algae and/or green algae, cause significant challenges in drinking water treatment due to the release of algogenic organic matter (AOM) into water extracellularly and, upon cell lysis, intracellularly.
Localization (release) of AOM associated with algogenic
8) Confidence 0.41 Published 2004 Journal Water Res. Section Abstract Doc Link 15016519 Disease Relevance 0 Pain Relevance 0.17
Gene expression of collagen type-II, collagen type-I, aggrecan, MMP-13, IL-6, Il-1?
Localization (aggrecan) of collagen type-II
9) Confidence 0.22 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.11 Pain Relevance 0
In the present study, prescriptions were highest for AOM and least for the common cold, a pattern observed in Turkey [20] and Scandinavia [21].
Localization (least) of AOM associated with common cold and otitis media
10) Confidence 0.21 Published 2004 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC441403 Disease Relevance 1.63 Pain Relevance 0.09
The cleavage of the type II collagen triple helix by collagenases results in the generation of neoepitopes at cleavage sites.
Localization (helix) of type II collagen in cleavage
11) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.07 Pain Relevance 0.03
When type II collagen is broken down, collagen fragments (CTX II) are released into the circulation and excreted in urine [59].
Localization (released) of type II collagen in urine
12) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 0.47 Pain Relevance 0.11

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