INT117244

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.19
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GABBR1) plasma membrane (GABBR1) transcription factor binding (GABBR1)
cytoplasm (GABBR1) signal transducer activity (GABBR1)
Anatomy Link Frequency
epithelium 4
vesicle 1
papilla 1
GABBR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABA receptor 5 100.00 Very High Very High Very High
adenocard 3 99.92 Very High Very High Very High
GABAergic 208 99.88 Very High Very High Very High
melanocortin 1 receptor 11 99.62 Very High Very High Very High
Opioid 1 98.88 Very High Very High Very High
gABA 246 98.60 Very High Very High Very High
Transcranial magnetic stimulation 36 98.60 Very High Very High Very High
Thalamus 11 93.68 High High
Cannabinoid 9 71.32 Quite High
anesthesia 10 62.28 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 272 100.00 Very High Very High Very High
Targeted Disruption 1 89.04 High High
Schizophrenia 106 82.64 Quite High
Congenital Anomalies 3 79.28 Quite High
Sleep Disorders 6 79.04 Quite High
Unconsciousness 6 76.52 Quite High
Dementia 2 64.12 Quite High
Affective Disorder 1 63.56 Quite High
Disorganized Schizophrenia 1 47.68 Quite Low
Cannabis Dependence 24 31.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 11 GABAergic gene expressed in the large airway epithelium of smokers included synthesis-related genes GAD67; receptors GABRB2, GABRB3, GABRE, GABRG1, GABRP, GABBR1; transport-related genes GAT-1,GAT-2 and metabolism-related genes GABA-T, ALDH5A1.
Gene_expression (expressed) of GABBR1 in epithelium associated with gaba, nicotine addiction and gabaergic
1) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.32 Pain Relevance 0.71
The 12 GABAergic gene expressed in the small airway epithelium of smokers included synthesis-related genes GAD67; receptors GABRB2, GABRB3, GABRE, GABRG1, GABRP, GABRR2, GABBR1; transport-related genes GAT-1,GAT-2 and metabolism-related genes GABA-T, ALDH5A1.
Gene_expression (expressed) of GABBR1 in epithelium associated with gaba, nicotine addiction and gabaergic
2) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.41 Pain Relevance 0.61
The 13 GABAergic genes expressed in the small airway epithelium of nonsmokers included synthesis-related genes GAD67; receptors GABRB2, GABRB3, GABRG1, GABRG3, GABRE, GABRP, GABRR2, GABBR1; transport-related genes GAT-1,GAT-2 and metabolism-related genes GABA-T, ALDH5A1.
Gene_expression (expressed) of GABBR1 in epithelium associated with gaba and gabaergic
3) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.41 Pain Relevance 0.65
The 13 GABAergic genes expressed in the large airway epithelium of nonsmokers included synthesis-related genes GAD67; receptors GABRB2, GABRB3, GABRE, GABRP, GABRR2, GABBR1, GABBR2; transport-related genes GAT-1,GAT-2, BGT-1 and metabolism-related genes GABA-T, ALDH5A1.
Gene_expression (expressed) of GABBR1 in epithelium associated with gaba and gabaergic
4) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.25 Pain Relevance 0.72
For the detection of GABAB-mediated cortical inhibition, the TMS measurement of the contralateral cortical silent period (CSP) seems to be a useful tool (Siebner et al. 1998; Werhahn et al. 1999).
Gene_expression (detection) of GABAB associated with transcranial magnetic stimulation
5) Confidence 0.12 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.55 Pain Relevance 0.55
We found expression of vesicle fusion and motility genes, ligand- and voltage-gated ion channels, receptor kinases and phosphatases, and, most interestingly, mRNA as well as protein expression of G protein-coupled receptors of neuromediators (corticotropin-releasing hormone 1 [CRH 1] and CRH 2 receptors, orexin/hypocretin 1 and 2 receptors, GABAB receptor, adenosine A(2)B receptor, opioid kappa 1 and mu 1 receptors, and 5-HT 1F receptor).
Gene_expression (expression) of GABAB receptor in vesicle associated with adenocard and opioid
6) Confidence 0.06 Published 2004 Journal Blood Section Abstract Doc Link 15016651 Disease Relevance 0 Pain Relevance 0.18
2 GABAA receptors, with denser GABA receptor expression in VB than in RTN [40-58].
Gene_expression (expression) of GABA receptor associated with gaba receptor
7) Confidence 0.02 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074352 Disease Relevance 0.24 Pain Relevance 0.44
Such pigment switching is controlled by the interaction of two genes: the melanocortin-1 receptor (Mc1r), which encodes a seven-transmembrane receptor expressed in melanocytes, and its ligand, agouti, whose protein product is secreted from nearby dermal papilla cells and acts to inhibit Mc1r signaling.
Gene_expression (expressed) of seven-transmembrane receptor in papilla associated with melanocortin 1 receptor
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0.49

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