INT117245

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.45
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CRHR1) signal transducer activity (CRHR1)
Anatomy Link Frequency
C127 2
vesicle 1
CRHR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 100.00 Very High Very High Very High
Inflammation 8 99.04 Very High Very High Very High
depression 2 97.56 Very High Very High Very High
drug abuse 1 96.96 Very High Very High Very High
adenocard 2 96.68 Very High Very High Very High
Opioid 1 95.64 Very High Very High Very High
addiction 1 78.80 Quite High
Neuropeptide 3 75.00 Quite High
agonist 1 69.12 Quite High
Pain 85 46.76 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.04 Very High Very High Very High
Disease 8 98.64 Very High Very High Very High
Anxiety Disorder 2 97.92 Very High Very High Very High
Depression 2 97.56 Very High Very High Very High
Drug Dependence 1 96.96 Very High Very High Very High
Chronic Renal Failure 8 93.08 High High
Syndrome 9 92.00 High High
Growth Hormone Deficiency 28 88.00 High High
Enteropathy 1 76.48 Quite High
Inflammatory Bowel Disease 1 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-peptide CRF1 antagonists have been recently synthesized for the treatment of CNS related diseases, such as anxiety, depression and drug abuse.
Gene_expression (synthesized) of CRF1 associated with depression, drug abuse, antagonist, anxiety disorder and disease
1) Confidence 0.51 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 15974983 Disease Relevance 1.53 Pain Relevance 0.56
We found expression of vesicle fusion and motility genes, ligand- and voltage-gated ion channels, receptor kinases and phosphatases, and, most interestingly, mRNA as well as protein expression of G protein-coupled receptors of neuromediators (corticotropin-releasing hormone 1 [CRH 1] and CRH 2 receptors, orexin/hypocretin 1 and 2 receptors, GABAB receptor, adenosine A(2)B receptor, opioid kappa 1 and mu 1 receptors, and 5-HT 1F receptor).
Gene_expression (expression) of corticotropin-releasing hormone 1 in vesicle associated with adenocard and opioid
2) Confidence 0.37 Published 2004 Journal Blood Section Abstract Doc Link 15016651 Disease Relevance 0 Pain Relevance 0.17
Device reliability encompasses not only the ability of the device to deliver the injection of r-hGH each time it is used, but also to confirm that the correct dose has been administered.
Gene_expression (injection) of r-hGH
3) Confidence 0.11 Published 2006 Journal BMC Endocr Disord Section Body Doc Link PMC1618831 Disease Relevance 0 Pain Relevance 0
However, all existing r-hGH products are administered subcutaneously, usually on a daily basis, and this can lead to problems with adherence [12].
Gene_expression (products) of r-hGH
4) Confidence 0.11 Published 2006 Journal BMC Endocr Disord Section Body Doc Link PMC1618831 Disease Relevance 0.45 Pain Relevance 0
Initially, r-hGH was produced using genetically engineered bacterial cells (Escherichia coli) [7], but in 1987 a mammalian cell-derived r-hGH preparation (produced by murine C127 cells) was introduced [8].
Gene_expression (produced) of r-hGH in C127
5) Confidence 0.10 Published 2006 Journal BMC Endocr Disord Section Body Doc Link PMC1618831 Disease Relevance 0.74 Pain Relevance 0
Initially, r-hGH was produced using genetically engineered bacterial cells (Escherichia coli) [7], but in 1987 a mammalian cell-derived r-hGH preparation (produced by murine C127 cells) was introduced [8].
Gene_expression (produced) of r-hGH in C127
6) Confidence 0.10 Published 2006 Journal BMC Endocr Disord Section Body Doc Link PMC1618831 Disease Relevance 0.73 Pain Relevance 0

General Comments

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