INT117246

Context Info Confidence 0.38 First Reported 2004 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.07 Pain Relevance 0.72

extracellular region (GABBR1) plasma membrane (GABBR1) transcription factor binding (GABBR1) cytoplasm (GABBR1) signal transducer activity (GABBR1)

Anatomy Link Frequency vesicle 1 trachea 1 GABBR1 (Homo sapiens)

Pain Link Frequency Relevance Heat adenocard 2 99.92 gABA 59 99.62 Opioid 1 98.88 agonist 2 87.60 GABAergic 46 59.28 Central nervous system 3 36.24 Neurotransmitter 4 32.88 Glutamate 5 5.28 Nicotine 9 5.00 antagonist 4 5.00

Disease Link Frequency Relevance Heat Generalized Anxiety Disorder 5 74.36 Nicotine Addiction 68 50.00 Asthma 4 5.00 Metaplasia 3 5.00 Hyperplasia 2 5.00 Pulmonary Disease 2 5.00 Stress 2 5.00 Sleep Disorders 1 5.00 Adenocarcinoma 1 5.00 Nervous System Malformation 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of the GABA-B receptors, both GABBR1 and GABBR2 subunits mRNA have been detected in human airway epithelium and both subunits have been identified by Western analysis and immunohistochemistry in guinea pig trachea [22].

Transcription (detected) of GABBR1 in trachea associated with gaba

1) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.07 Pain Relevance 0.55

We found expression of vesicle fusion and motility genes, ligand- and voltage-gated ion channels, receptor kinases and phosphatases, and, most interestingly, mRNA as well as protein expression of G protein-coupled receptors of neuromediators (corticotropin-releasing hormone 1 [CRH 1] and CRH 2 receptors, orexin/hypocretin 1 and 2 receptors, GABAB receptor, adenosine A(2)B receptor, opioid kappa 1 and mu 1 receptors, and 5-HT 1F receptor).

Spec (found) Transcription (found) of GABAB receptor in vesicle associated with adenocard and opioid

2) Confidence 0.03 Published 2004 Journal Blood Section Abstract Doc Link 15016651 Disease Relevance 0 Pain Relevance 0.18

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