INT117246

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GABBR1) plasma membrane (GABBR1) transcription factor binding (GABBR1)
cytoplasm (GABBR1) signal transducer activity (GABBR1)
Anatomy Link Frequency
vesicle 1
trachea 1
GABBR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 2 99.92 Very High Very High Very High
gABA 59 99.62 Very High Very High Very High
Opioid 1 98.88 Very High Very High Very High
agonist 2 87.60 High High
GABAergic 46 59.28 Quite High
Central nervous system 3 36.24 Quite Low
Neurotransmitter 4 32.88 Quite Low
Glutamate 5 5.28 Low Low
Nicotine 9 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 5 74.36 Quite High
Nicotine Addiction 68 50.00 Quite Low
Asthma 4 5.00 Very Low Very Low Very Low
Metaplasia 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Pulmonary Disease 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Adenocarcinoma 1 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the GABA-B receptors, both GABBR1 and GABBR2 subunits mRNA have been detected in human airway epithelium and both subunits have been identified by Western analysis and immunohistochemistry in guinea pig trachea [22].
Transcription (detected) of GABBR1 in trachea associated with gaba
1) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.07 Pain Relevance 0.55
We found expression of vesicle fusion and motility genes, ligand- and voltage-gated ion channels, receptor kinases and phosphatases, and, most interestingly, mRNA as well as protein expression of G protein-coupled receptors of neuromediators (corticotropin-releasing hormone 1 [CRH 1] and CRH 2 receptors, orexin/hypocretin 1 and 2 receptors, GABAB receptor, adenosine A(2)B receptor, opioid kappa 1 and mu 1 receptors, and 5-HT 1F receptor).
Spec (found) Transcription (found) of GABAB receptor in vesicle associated with adenocard and opioid
2) Confidence 0.03 Published 2004 Journal Blood Section Abstract Doc Link 15016651 Disease Relevance 0 Pain Relevance 0.18

General Comments

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