INT117249

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.34
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1)
cytoplasm (Tjp1)
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 92.40 High High
ischemia 12 85.92 High High
Inflammation 38 78.88 Quite High
interstitial cystitis 2 50.00 Quite Low
imagery 5 16.48 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uveitis 42 99.84 Very High Very High Very High
Diabetes Mellitus 90 98.60 Very High Very High Very High
Adhesions 6 98.60 Very High Very High Very High
Cv Unclassified Under Development 5 85.92 High High
Diabetic Retinopathy 5 83.96 Quite High
INFLAMMATION 36 78.88 Quite High
Interstitial Cystitis 2 50.00 Quite Low
Pressure And Volume Under Development 9 48.56 Quite Low
Brain Hemorrhage 22 45.20 Quite Low
Hematoma 4 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, immunoelectron microscopy showed that this effect is associated with delocalization as well as diminished immunogold signals of tight junctional proteins, including occludin, claudin 5 and ZO-1 [15].
Negative_regulation (diminished) of ZO-1
1) Confidence 0.29 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
The disruption of ZO-1 is similar to that reported in feline IC.
Negative_regulation (disruption) of ZO-1
2) Confidence 0.23 Published 2004 Journal J. Urol. Section Body Doc Link 15017219 Disease Relevance 0 Pain Relevance 0
Fluorescence of ZO-1 and occludin was decreased in EIU compared to control rats in intercellular spaces (data not shown).
Negative_regulation (decreased) of ZO-1 associated with uveitis
3) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2435159 Disease Relevance 0.54 Pain Relevance 0.10
Chehade et al. (37) reported that occludin but not zona occludens-1 levels are decreased at 2 weeks after the induction of diabetes by STZ injection.
Negative_regulation (decreased) of occludens-1 associated with diabetes mellitus
4) Confidence 0.04 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.80 Pain Relevance 0.18

General Comments

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