INT117252

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 12.44
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTT1) cytoplasm (GSTT1)
Anatomy Link Frequency
leukocyte 2
GSTT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 2 90.40 High High
drug abuse 2 25.92 Quite Low
Angina 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 402 99.64 Very High Very High Very High
Cancer 54 99.20 Very High Very High Very High
Coronary Artery Disease 342 99.16 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

20 99.10 Very High Very High Very High
Disease 30 98.84 Very High Very High Very High
Diabetes Mellitus 44 98.82 Very High Very High Very High
Hypertension 40 98.62 Very High Very High Very High
Berylliosis 2 94.16 High High
Myocardial Infarction 20 92.24 High High
Obesity 28 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers.
Regulation (involve) of GSTT1 in leukocyte associated with berylliosis, cancer and carpal tunnel syndrome
1) Confidence 0.45 Published 2004 Journal Scand J Work Environ Health Section Abstract Doc Link 15018031 Disease Relevance 0.28 Pain Relevance 0.09
As we considered the effect of GSTM1/GSTT1 genotype on the multivessel disease, there was no significant difference in GSTM1/GSTT1 genotype in relation to the number of involved vessel in both smokers and non-smokers (Table 7).
Regulation (effect) of GSTT1 associated with nicotine addiction and disease
2) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.27 Pain Relevance 0
Also the effect of GSTT1 gene polymorphism on smoking-related CAD showed the same tendency as GSTM1 gene (OR, 2.00, CI, 1.05-3.84).
Regulation (effect) of GSTT1 associated with coronary artery disease and nicotine addiction
3) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2526535 Disease Relevance 1.30 Pain Relevance 0
Also, there was no significant effect of GSTM1/GSTT1 genotype on the severity of CAD (Table 8).
Neg (no) Regulation (effect) of GSTT1 associated with coronary artery disease
4) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.44 Pain Relevance 0
After adjusting other coronary risk factors such as hypertension, diabetes, dyslipidemia, age, and sex than smoking, the interactive effect GSTM1/GSTT1 gene and smoking on CAD remained statistically significant (in smokers with GSTM1 null genotype, OR, 2.01, CI, 1.13-3.69, p=0.01/in smokers with GSTT1 null genotype, OR, 1.89, CI, 1.03-3.13, p=0.02) (Table 5, 6).
Regulation (effect) of GSTT1 associated with coronary artery disease, nicotine addiction, diabetes mellitus and hypertension
5) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.24 Pain Relevance 0
Therefore, our aim is to investigate the possible relevance of the GSTM1 and GSTT1 polymorphisms either individually or combined (haplotype) on the development of CAD.
Spec (possible) Regulation (relevance) of GSTT1 associated with coronary artery disease
6) Confidence 0.42 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.48 Pain Relevance 0
The variables showing an association (p < .05) in Table 2 were then put into a stepwise multiple logistic regression, in order to study the possible combined effect of the GSTT1 plus GSTM1 haplotype with other risk factors on CAD manifestation.
Spec (possible) Regulation (effect) of GSTT1 associated with coronary artery disease
7) Confidence 0.42 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.73 Pain Relevance 0
The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers.
Regulation (involve) of glutathione-S-transferase theta 1 in leukocyte associated with berylliosis, cancer and carpal tunnel syndrome
8) Confidence 0.39 Published 2004 Journal Scand J Work Environ Health Section Abstract Doc Link 15018031 Disease Relevance 0.28 Pain Relevance 0.09

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