INT117254

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PMP22) plasma membrane (PMP22)
Anatomy Link Frequency
leukocyte 2
Schwann cells 2
PMP22 (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 1 99.80 Very High Very High Very High
agonist 4 99.54 Very High Very High Very High
gABA 69 99.36 Very High Very High Very High
Sciatic nerve 2 98.68 Very High Very High Very High
c fibre 42 95.84 Very High Very High Very High
dorsal root ganglion 13 90.56 High High
unmyelinated 38 77.72 Quite High
GABA receptor 1 70.36 Quite High
Central nervous system 3 44.32 Quite Low
Action potential 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Berylliosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Carpal Tunnel Syndrome 1 99.80 Very High Very High Very High
Ganglion Cysts 13 90.56 High High
Neuropathic Pain 4 47.96 Quite Low
Nociception 8 18.48 Low Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Amputation 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers.
Regulation (involve) of Gene_expression (deletion) of peripheral myelin protein 22 in leukocyte associated with berylliosis, cancer and carpal tunnel syndrome
1) Confidence 0.37 Published 2004 Journal Scand J Work Environ Health Section Abstract Doc Link 15018031 Disease Relevance 0.30 Pain Relevance 0.10
However both GABAA and GABAB receptors have been immunohistochemically identified in cultured Schwann cells from rat [30] and segments of rat sciatic nerve [31] and their activation by GABA agonists has been suggested to influence the expression of myelin proteins P0 and PMP22 [30].
Regulation (influence) of Gene_expression (expression) of PMP22 in Schwann cells associated with gaba, agonist and sciatic nerve
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.51 Pain Relevance 0.83

General Comments

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