INT117268

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.99
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PLA2G2A) extracellular region (PLA2G2A) endoplasmic reticulum (PLA2G2A)
PLA2G2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 54 100.00 Very High Very High Very High
Potency 7 94.48 High High
Pain 2 89.56 High High
Bile 8 68.56 Quite High
Arthritis 4 65.40 Quite High
Inflammatory mediators 3 60.72 Quite High
antagonist 3 57.12 Quite High
adenocard 1 42.40 Quite Low
nociceptor 1 25.00 Low Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 57 100.00 Very High Very High Very High
Nociception 4 96.84 Very High Very High Very High
Atherosclerotic Plaque 6 90.88 High High
Pain 2 89.56 High High
Atherosclerosis 37 86.64 High High
Disorder Of Lipid Metabolism 18 80.80 Quite High
Pancreatitis 2 66.36 Quite High
Arthritis 4 65.40 Quite High
Adult Respiratory Distress Syndrome 2 64.96 Quite High
Shock 2 63.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies have provided a boost to the research in this field and various approaches have been used to identify the amino acid residues and the specific sites of interaction of myotoxic PLA2s with cell membranes potentially involved in the PLA2-induced inflammatory and nociceptive effects.
PLA2s Binding (interaction) of associated with nociception and inflammation
1) Confidence 0.42 Published 2003 Journal Toxicon Section Abstract Doc Link 15019493 Disease Relevance 0.90 Pain Relevance 0.36
sPLA2-IIA, the possible link between activated RAS, inflammation, and lipidperoxidation: a target for treatment?
sPLA2-IIA Binding (target) of associated with inflammation
2) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.59 Pain Relevance 0.13
-hydroxybutenolide ring is involved in the initial interaction with PLA2 and (3) the hydrophobic nature of the trimethylcyclohexenyl ring system allows non-bonded interactions with the enzyme that enhances the potency of these analogs.
PLA2 Binding (interaction) of associated with potency
3) Confidence 0.24 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852841 Disease Relevance 0 Pain Relevance 0.05
The covalent binding of 46 to bee venom PLA2 has been investigated by mass spectrometry and molecular modeling.
PLA2 Binding (binding) of
4) Confidence 0.21 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852841 Disease Relevance 0.42 Pain Relevance 0.11
In this model, CEase does not have a direct transport role in the absorption of free cholesterol but rather has an indirect role by virtue of its participation with PLA2 in the formation of lysolecithin-containing micelles.
PLA2 Binding (participation) of
5) Confidence 0.05 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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