INT11729

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 2010
Negated 9
Speculated 6
Reported most in Body
Documents 71
Total Number 80
Disease Relevance 44.58
Pain Relevance 9.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
plasma 3
liver 2
pituitary 2
body 2
Chondrocytes 1
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 324 100.00 Very High Very High Very High
cINOD 33 100.00 Very High Very High Very High
Bioavailability 19 100.00 Very High Very High Very High
COX2 5 100.00 Very High Very High Very High
agonist 229 99.90 Very High Very High Very High
Dopamine 226 99.72 Very High Very High Very High
Clonidine 22 99.66 Very High Very High Very High
Somatostatin 206 99.32 Very High Very High Very High
cytokine 82 98.64 Very High Very High Very High
Fibrositis 41 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 324 100.00 Very High Very High Very High
INFLAMMATION 203 100.00 Very High Very High Very High
Insulin Resistance 120 99.98 Very High Very High Very High
Growth Problems 31 99.96 Very High Very High Very High
Prostate Cancer 140 99.86 Very High Very High Very High
Diabetes Mellitus 157 99.84 Very High Very High Very High
Aging 47 99.70 Very High Very High Very High
Hypoglycemia 21 99.64 Very High Very High Very High
Cancer 556 99.56 Very High Very High Very High
Disease 833 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts.
Regulation (Modulation) of insulin-like growth factor 1 in osteoblasts associated with cox2 and osteoarthritis
1) Confidence 0.61 Published 2006 Journal Bone Section Title Doc Link 16257278 Disease Relevance 1.44 Pain Relevance 0.61
In conclusion, this randomized controlled trial did not demonstrate an effect of Acclydine on biologically active IGF1, nor did it demonstrate any benefit in CFS-related outcome measures.
Regulation (effect) of IGF1 associated with chronic fatigue syndrome
2) Confidence 0.61 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1876596 Disease Relevance 0.33 Pain Relevance 0
In addition to regulating the bioavailability of plasma IGFs, IGFBP3 is expressed locally in most if not all tissues including the intestine [31].
Regulation (regulating) of IGF in intestine associated with bioavailability
3) Confidence 0.60 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.05 Pain Relevance 0.05
One possibility is that the chemosensory neurons regulate the activity of the insulin/IGF-1 signaling pathway.
Regulation (regulate) of IGF-1 in chemosensory neurons
4) Confidence 0.60 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2565500 Disease Relevance 0.93 Pain Relevance 0.03
METHODS: We studied the influence of rhIGF-I on the growth of two rhabdomyosarcoma cell lines (Rh30 and Rh1) and on the antitumor effects of vincristine, cisplatin, etoposide, doxorubicin, and topotecan under serum-free and serum-containing conditions.
Regulation (influence) of rhIGF-I
5) Confidence 0.44 Published 2000 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 10647497 Disease Relevance 0 Pain Relevance 0
There was no effect of gender, use of nonsteroidal anti-inflammatory drugs or tricyclic drugs on levels of somatomedin C.
Neg (no) Regulation (effect) of somatomedin C associated with inflammation and cinod
6) Confidence 0.44 Published 1997 Journal J Psychiatr Res Section Abstract Doc Link 9201651 Disease Relevance 0.78 Pain Relevance 0.30
In 2008, Akin et al. [30] reported that GH-IGF axis was affected in the patients with subclinical hypothyroidism and that L-T4 replacement therapy could prevent abnormalities related to GH-IGF axis in them.
Regulation (affected) of IGF associated with hypothyroidism and congenital anomalies
7) Confidence 0.44 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 1.03 Pain Relevance 0
The purpose of this study was to determine the effects of recombinant human GH (rhGH; 0.025 mg/kg.day) and one of two doses of recombinant human insulin-like growth factor-I (rhIGF-I; 0.015 and 0.060 mg/kg, twice daily) on body composition in elderly women.
Regulation (effects) of IGF in body
8) Confidence 0.44 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7539817 Disease Relevance 0 Pain Relevance 0
GH response to provocation and circulating IGF-I and IGF-binding protein-3 concentrations, the IGF-I generation test and clinical response to GH therapy in children with beta-thalassaemia.
Regulation (response) of IGF-I associated with thalassemia
9) Confidence 0.42 Published 1998 Journal Eur. J. Endocrinol. Section Title Doc Link 9578506 Disease Relevance 0.64 Pain Relevance 0.16
Furthermore, all subjects in the present study were healthy, with no known confounding disease or condition that may influence IGF-1 or IGFBP-3 concentrations.
Spec (may) Regulation (influence) of IGF-1 associated with disease
10) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669552 Disease Relevance 1.16 Pain Relevance 0
Furthermore, subjects were often not matched for gender and/or age, both known to influence systemic IGF-1 and IGFBP-3 concentrations.
Regulation (influence) of IGF-1
11) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671651 Disease Relevance 1.29 Pain Relevance 0
Furthermore, all subjects in the present study were healthy, with no known confounding disease or condition that may influence IGF-1 or IGFBP-3 concentrations.
Spec (may) Regulation (influence) of IGF-1 associated with disease
12) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671651 Disease Relevance 1.16 Pain Relevance 0
Furthermore, subjects were often not matched for gender and/or age, both known to influence systemic IGF-1 and IGFBP-3 concentrations.
Regulation (influence) of IGF-1
13) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669552 Disease Relevance 1.29 Pain Relevance 0
RESULTS: A total of 13 cases of injection-site lipoatrophy were reported, of which ten were in females and three occurred after the first injection; all cases were independent of PEG-GH dose or IGF1 levels, either basal or under treatment.
Neg (independent) Regulation (independent) of IGF1
14) Confidence 0.39 Published 2009 Journal Eur. J. Endocrinol. Section Body Doc Link 19654233 Disease Relevance 0 Pain Relevance 0
Plasma and tissue IGFBPs modulate the bioavailability of IGF-I and IGF-II and possess anti-proliferative and pro-apoptotic properties.
Regulation (modulate) of IGF-I in Plasma associated with apoptosis and bioavailability
15) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.03 Pain Relevance 0.05
The ternary complex stabilize the concentration of IGF-1 in plasma and regulates the efflux of free IGF-1 from the vascular space [14].
Regulation (regulates) of IGF-1 in plasma
16) Confidence 0.38 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.20 Pain Relevance 0
In general, patients with ESRD appear to exhibit normal or high concentrations of IGF-I and considerably elevated concentrations of IGFBP-I and IGFBP-III, which increase with declining renal function,13 demonstrating that the GH–IGF-I axis is affected on several levels.
Regulation (affected) of IGF-I associated with chronic renal failure
17) Confidence 0.37 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.50 Pain Relevance 0
The changes in IGF-I and IGFBPs in patients with RA were associated with nonsignificantly higher 24-hour total GH production rates.
Regulation (changes) of IGF-I associated with rheumatoid arthritis
18) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.84 Pain Relevance 0.39
The most striking effects of leptin in obese patients, that is the up-regulation of IGF-1, collagen type 2 and MMP-13, were found with the highest concentration of leptin.
Regulation (regulation) of IGF-1 associated with obesity
19) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.98 Pain Relevance 0.05
To determine whether systemic and/or intraovarian concentrations of insulin-like growth factor-I (IGF-I) are affected by short-term fasting, 24 heifers were blocked by weight and, within block, were assigned to one of three treatments: fasted for 0 h (controls; n = 8), fasted for 24 h (n = 8), or fasted for 48 h (n = 8).
Spec (whether) Regulation (affected) of IGF-I
20) Confidence 0.27 Published 1992 Journal Biol. Reprod. Section Abstract Doc Link 1591347 Disease Relevance 0 Pain Relevance 0.07

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