INT117299

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 1.58
Pain Relevance 6.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)
Anatomy Link Frequency
astrocyte 4
blood 1
nervous system 1
carotid artery 1
heart 1
S100b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 24 99.92 Very High Very High Very High
anesthesia 20 99.42 Very High Very High Very High
tetrodotoxin 21 99.26 Very High Very High Very High
Serotonin 24 99.14 Very High Very High Very High
sSRI 18 99.00 Very High Very High Very High
sodium channel 7 98.80 Very High Very High Very High
Calcium channel 7 97.12 Very High Very High Very High
Glutamate 9 94.72 High High
antidepressant 12 93.64 High High
Central nervous system 20 82.68 Quite High
Disease Link Frequency Relevance Heat
Metastasis 71 99.72 Very High Very High Very High
Non-small-cell Lung Cancer 2 94.96 High High
Stroke 8 93.36 High High
Lung Cancer 5 92.20 High High
INFLAMMATION 4 74.28 Quite High
Cv General 4 Under Development 3 72.84 Quite High
Disease 9 66.16 Quite High
Injury 5 65.20 Quite High
Skin Cancer 4 60.00 Quite High
Death 6 41.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when slices were transferred to a medium containing oxygen and glucose (reoxygenation conditions, or REO), S100B release reached 500% of its control value.
Localization (release) of S100B
1) Confidence 0.78 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.03
Mechanism of S100b release from rat cortical slices determined under basal and stimulated conditions.
Localization (release) of S100b
2) Confidence 0.78 Published 2010 Journal Neurochem. Res. Section Title Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.20
Blockade of calcium channels with verapamil, chelating the Ca(+2) ions with BAPTA or blockade of sodium channels with tetrodotoxin (TTX) did not alter OGD- and REO-induced S100B release.
Localization (release) of S100B associated with tetrodotoxin, calcium channel and sodium channel
3) Confidence 0.78 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.41
Additionally, calcium and sodium currents that are sensitive to verapamil and TTX, respectively, are unlikely to contribute to the enhanced S100B release observed under these conditions.
Localization (release) of S100B associated with tetrodotoxin
4) Confidence 0.78 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.37
Moreover, we found that serotonin (possibly via the 5HT1A receptor) reduces S100B secretion and antagonizes the effect of fluoxetine on S100B secretion.
Localization (secretion) of S100B associated with serotonin and fluoxetine
5) Confidence 0.78 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.74
Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin.
Localization (Secretion) of S100B in astrocyte associated with serotonin and fluoxetine
6) Confidence 0.78 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.63
Here, we measured S100B secretion directly in hippocampal astrocyte cultures and hippocampal slices exposed to fluoxetine and observed a significant increment of S100B release in the presence of this SSRI, apparently dependent on protein kinase A (PKA).
Localization (release) of S100B in astrocyte associated with ssri and fluoxetine
7) Confidence 0.78 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.71
S100B is a calcium-binding protein, produced and secreted by astrocytes, which has a putative paracrine neurotrophic activity.
Localization (secreted) of S100B in astrocytes
8) Confidence 0.73 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.35
Moreover, individual inhibition of PKC, PLA(2) or PLC all failed to attenuate the S100B release determined under control condition or enhanced by either OGD or REO.
Localization (release) of S100B
9) Confidence 0.68 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.30
Incubation of rat cortical slices in a medium that was not containing oxygen and glucose (oxygen-glucose deprivation, OGD) caused a 200% increase in the release of S100B.
Localization (release) of S100B
10) Confidence 0.68 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0
Neither inhibition of nitric oxide (NO) synthase by L-NAME nor addition of the NO donors sodium nitroprussid (SNP) or hydroxylamine (HA) to the medium altered basal S100B release.
Localization (release) of S100B
11) Confidence 0.68 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19823932 Disease Relevance 0 Pain Relevance 0.22
Moreover, we found that serotonin (possibly via the 5HT1A receptor) reduces S100B secretion and antagonizes the effect of fluoxetine on S100B secretion.
Localization (secretion) of S100B associated with serotonin and fluoxetine
12) Confidence 0.68 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.75
Here, we measured S100B secretion directly in hippocampal astrocyte cultures and hippocampal slices exposed to fluoxetine and observed a significant increment of S100B release in the presence of this SSRI, apparently dependent on protein kinase A (PKA).
Localization (secretion) of S100B in astrocyte associated with ssri and fluoxetine
13) Confidence 0.68 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.67
Although several clinical studies have shown that increased serum concentrations of protein S100B predict ischaemic brain damage after cardiac surgery, S100B may also be released from the heart or other injured tissue.
Localization (released) of S100B in heart
14) Confidence 0.67 Published 2004 Journal Anaesthesia Section Abstract Doc Link 15023104 Disease Relevance 0.06 Pain Relevance 0.05
S100B is a nervous system specific cytoplasmic protein found in astrocytes and is released into circulation when the blood brain barrier is breached [78].
Localization (released) of S100B in nervous system
15) Confidence 0.63 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2556333 Disease Relevance 1.31 Pain Relevance 0.28
Cerebral and extracerebral release of protein S100B in cardiac surgical patients.
Localization (release) of S100B
16) Confidence 0.59 Published 2004 Journal Anaesthesia Section Title Doc Link 15023104 Disease Relevance 0.07 Pain Relevance 0.07
S-100B release did not differ at any time point between patients who needed and patients who did not need a shunt, in either the arterial or the venous blood samples.
Localization (release) of S-100B in blood
17) Confidence 0.52 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17521874 Disease Relevance 0.07 Pain Relevance 0.27
The aim of the study was to evaluate whether cross-clamping of the carotid artery for carotid endarterectomy (CEA) under local anesthesia is associated with the same S-100B release pattern as during general anesthesia, where an increase in S-100B concentration in the jugular vein blood of 120% has been reported.
Localization (release) of S-100B in carotid artery associated with anesthesia
18) Confidence 0.51 Published 2007 Journal Ann Vasc Surg Section Abstract Doc Link 17521874 Disease Relevance 0 Pain Relevance 0.36
S-100B release during carotid endarterectomy under local anesthesia.
Localization (release) of S-100B associated with anesthesia
19) Confidence 0.45 Published 2007 Journal Ann Vasc Surg Section Title Doc Link 17521874 Disease Relevance 0.06 Pain Relevance 0.38

General Comments

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