INT117308

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.16
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 2
3T3-L1 2
adipocytes 2
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 8 92.00 High High
Inflammation 25 90.32 High High
qutenza 3 82.48 Quite High
cytokine 5 80.08 Quite High
Cholecystokinin 2 78.48 Quite High
Inflammatory mediators 2 67.68 Quite High
antagonist 1 63.60 Quite High
Hippocampus 5 53.84 Quite High
Thalamus 3 52.60 Quite High
Osteoarthritis 21 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ulcers 11 99.50 Very High Very High Very High
Obesity 21 97.52 Very High Very High Very High
Sprains And Strains 2 96.52 Very High Very High Very High
INFLAMMATION 29 90.32 High High
Necrosis 4 89.72 High High
Cancer 3 89.36 High High
Body Weight 32 84.56 Quite High
Disease 6 58.36 Quite High
Nicotine Addiction 1 58.08 Quite High
Frailty 22 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bleau et al. [1] described Lactobacillus-induced decrease in leptin release by adipocyte derived from SJL mice, whereas the same Lactobacillus preparation led to an increase in leptin release when used to treat C57BL/6 adipocytes.
Negative_regulation (decrease) of Localization (release) of leptin in adipocytes associated with obesity
1) Confidence 0.59 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.40 Pain Relevance 0.13
Hp-LPS injected repeatedly suppressed the gastric acid secretion, up-regulated leptin mRNA and protein, and increased plasma leptin and gastrin levels.
Negative_regulation (suppressed) of Localization (secretion) of leptin in plasma associated with ulcers
2) Confidence 0.16 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15024038 Disease Relevance 0.88 Pain Relevance 0.50
In addition, berberine reduced secretion of leptin, which regulates appetite and energy metabolism, from 3T3-L1 adipocytes.
Negative_regulation (reduced) of Localization (secretion) of leptin in 3T3-L1 associated with obesity
3) Confidence 0.05 Published 2009 Journal Nutr J Section Body Doc Link PMC2739863 Disease Relevance 0.88 Pain Relevance 0.24

General Comments

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