INT117308

Context Info Confidence 0.59 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.16 Pain Relevance 0.86

extracellular space (Lep) extracellular region (Lep) intracellular (Lep) lipid metabolic process (Lep)

Anatomy Link Frequency plasma 2 3T3-L1 2 adipocytes 2 Lep (Rattus norvegicus)

Pain Link Frequency Relevance Heat aspirin 8 92.00 Inflammation 25 90.32 qutenza 3 82.48 cytokine 5 80.08 Cholecystokinin 2 78.48 Inflammatory mediators 2 67.68 antagonist 1 63.60 Hippocampus 5 53.84 Thalamus 3 52.60 Osteoarthritis 21 50.00

Disease Link Frequency Relevance Heat Ulcers 11 99.50 Obesity 21 97.52 Sprains And Strains 2 96.52 INFLAMMATION 29 90.32 Necrosis 4 89.72 Cancer 3 89.36 Body Weight 32 84.56 Disease 6 58.36 Nicotine Addiction 1 58.08 Frailty 22 50.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Bleau et al. [1] described Lactobacillus-induced decrease in leptin release by adipocyte derived from SJL mice, whereas the same Lactobacillus preparation led to an increase in leptin release when used to treat C57BL/6 adipocytes.

Negative_regulation (decrease) of Localization (release) of leptin in adipocytes associated with obesity

1) Confidence 0.59 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.40 Pain Relevance 0.13

Hp-LPS injected repeatedly suppressed the gastric acid secretion, up-regulated leptin mRNA and protein, and increased plasma leptin and gastrin levels.

Negative_regulation (suppressed) of Localization (secretion) of leptin in plasma associated with ulcers

2) Confidence 0.16 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15024038 Disease Relevance 0.88 Pain Relevance 0.50

In addition, berberine reduced secretion of leptin, which regulates appetite and energy metabolism, from 3T3-L1 adipocytes.

Negative_regulation (reduced) of Localization (secretion) of leptin in 3T3-L1 associated with obesity

3) Confidence 0.05 Published 2009 Journal Nutr J Section Body Doc Link PMC2739863 Disease Relevance 0.88 Pain Relevance 0.24

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