INT11732

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 15.73
Pain Relevance 8.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
plasma 2
paraventricular hypothalamic nucleus 1
nerve 1
brain 1
nucleus 1
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 83 100.00 Very High Very High Very High
depression 26 100.00 Very High Very High Very High
Nerve growth factor 12 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Clonidine 3 99.98 Very High Very High Very High
cytokine 15 99.62 Very High Very High Very High
Inflammatory response 9 99.30 Very High Very High Very High
antagonist 20 99.20 Very High Very High Very High
orphanin 4 99.00 Very High Very High Very High
Arthritis 56 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 32 100.00 Very High Very High Very High
Depression 31 100.00 Very High Very High Very High
Cancer 16 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Natriuresis 3 100.00 Very High Very High Very High
Appetite Loss 21 99.98 Very High Very High Very High
Myocardial Infarction 9 99.84 Very High Very High Very High
INFLAMMATION 89 99.42 Very High Very High Very High
Neuropathic Pain 97 99.38 Very High Very High Very High
Cardiovascular Disease 3 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, there was a significant decrease in mRNA level of corticotropin-releasing factor in the paraventricular hypothalamic nucleus in the HLJDT-treated rats.
Negative_regulation (decrease) of factor in paraventricular hypothalamic nucleus
1) Confidence 0.30 Published 2000 Journal Life Sci. Section Abstract Doc Link 10658920 Disease Relevance 0.73 Pain Relevance 0.65
Diabetic cystopathy correlates with a long-term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root Ganglia.
Negative_regulation (decrease) of factor in nerve associated with nerve growth factor and diabetes mellitus
2) Confidence 0.14 Published 2002 Journal J. Urol. Section Title Doc Link 12187278 Disease Relevance 0.86 Pain Relevance 0.45
Clonidine prevents corticotropin releasing factor-induced epileptogenic activity in rats.
Negative_regulation (prevents) of factor associated with clonidine
3) Confidence 0.14 Published 1992 Journal Epilepsia Section Title Doc Link 1592016 Disease Relevance 0 Pain Relevance 0.31
A new theory proposes that neuropathy may arise as a consequence of loss of neurotrophic insulin-like growth factor (IGF) activity due to diabetes, superimposed on a slow continual loss due to aging.
Negative_regulation (loss) of factor associated with aging, diabetes mellitus and neuropathic pain
4) Confidence 0.11 Published 1996 Journal Exp. Neurol. Section Abstract Doc Link 8690062 Disease Relevance 0.97 Pain Relevance 0.23
It is suggested that the long-searched corticotropin releasing factor and PRL release-inhibiting factor may be a sauvagine-like peptide.
Negative_regulation (inhibiting) of factor
5) Confidence 0.09 Published 1981 Journal Peptides Section Abstract Doc Link 6178095 Disease Relevance 0.09 Pain Relevance 0.14
Chemotactic activity of the nondialyzable chemotactic factor was reduced after treatment with heat (56 degrees C, 30 min) or trypsin.
Negative_regulation (reduced) of factor
6) Confidence 0.08 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7648987 Disease Relevance 0.09 Pain Relevance 0.48
Chemotactic activity of a 25-kDa factor was reduced by the antibody against the antibody against KC/gro protein, but that of a 55-kDa factor was not reduced.
Negative_regulation (reduced) of factor
7) Confidence 0.08 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7648987 Disease Relevance 0.07 Pain Relevance 0.57
Inhibition of platelet-activating factor receptors in hippocampal plasma membranes attenuates the inflammatory nociceptive response in rats.
Negative_regulation (Inhibition) of factor in plasma associated with nociception and inflammation
8) Confidence 0.08 Published 2006 Journal Brain Res. Section Title Doc Link 16774744 Disease Relevance 0.73 Pain Relevance 0.54
However, whether such an action is mediated through a depression on epidermal growth factor (EGF) is undefined.
Negative_regulation (depression) of factor associated with depression
9) Confidence 0.08 Published 2000 Journal Life Sci. Section Abstract Doc Link 11210723 Disease Relevance 0.71 Pain Relevance 0.53
The inactivation of rat atrial natriuretic factor (ANF) was studied using a bioassay, ANF-stimulated guanylate cyclase activity.
Negative_regulation (inactivation) of factor associated with natriuresis
10) Confidence 0.07 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2973321 Disease Relevance 0.17 Pain Relevance 0.09
A decrease in the factor may cause PG I2 deficiency, resulting in coronary thrombosis or vasospasm and consequently in acute myocardial infarction.
Negative_regulation (decrease) of factor associated with increased venous pressure under development, thrombosis related under development and myocardial infarction
11) Confidence 0.04 Published 1986 Journal Jpn Heart J Section Abstract Doc Link 3553641 Disease Relevance 1.18 Pain Relevance 0.29
This conclusion is based in the following observations: (a) rats in our model display reduced anxiety on an elevated plus-maze; (b) in the forced swim test, these rats exhibit behavioral characteristics associated with stronger ability for stress coping; and (c) these animals have reduced basal and stress-induced plasma levels of such stress-related neuroendocrine markers as corticotropin-releasing factor, vasopressin, and adrenocorticotrophic hormone.
Negative_regulation (reduced) of factor in plasma associated with stress, eae and anxiety disorder
12) Confidence 0.04 Published 2005 Journal Neuroscience Section Abstract Doc Link 15730869 Disease Relevance 1.56 Pain Relevance 0.65
Diflunisal and benoxaprofen (20-100 microM) produced dose-dependent inhibitions of lyso-platelet activating factor: acetyl-CoA acetyltransferase in a lysate of rat pleural neutrophils.
Negative_regulation (inhibitions) of factor in neutrophils
13) Confidence 0.04 Published 1988 Journal Prostaglandins Section Abstract Doc Link 2903520 Disease Relevance 0.08 Pain Relevance 0.14
The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ.
Negative_regulation (effect) of factor in nucleus associated with appetite loss and orphanin
14) Confidence 0.03 Published 2003 Journal J. Neurosci. Section Title Doc Link 14561874 Disease Relevance 0.42 Pain Relevance 0.62
Some reports revealed that the possibility of inhibiting both fibrotic response and inflammatory response by copper chelation is due to the suppression of transforming growth factor beta and TNF-?
Negative_regulation (suppression) of factor associated with fibrosis and inflammatory response
15) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297562 Disease Relevance 0.92 Pain Relevance 0.18
Our results show that local administration of WIN 55,212-2, a CB(1)/CB(2) agonist, given daily or at time of implantation significantly decreased weight and neo-angiogenesis in granuloma tissue and inhibited nuclear factor-kappa B (NF-kappaB)/DNA binding that was associated with a reduced inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) messenger RNA (mRNA) and protein expression.
Negative_regulation (reduced) of factor associated with necrosis, cancer, agonist, cox2 and granuloma
16) Confidence 0.01 Published 2007 Journal J. Mol. Med. Section Abstract Doc Link 17447045 Disease Relevance 0.83 Pain Relevance 0.56
In addition, many genes associated with axonal regeneration, and with a number of growth factor receptors (i.e.
Negative_regulation (number) of factor
17) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.51 Pain Relevance 0.05
None of the studies regarding EEG changes from modafinil that we found measured modafinil’s effects on event-related EEG changes in instances of mental exertion, but modafinil’s resting EEG profile and stimulant properties do suggest that it would enhance mental performance, at least in individuals in the condition of sleep-deprivation, a common factor in stimulant abusers.
Negative_regulation (deprivation) of factor
18) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0.26 Pain Relevance 0
B confers a protective effect through upregulation of IL-6 and downregulation of transforming growth factor-?
Negative_regulation (downregulation) of factor
19) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2551692 Disease Relevance 1.00 Pain Relevance 0.44
These include inhibition of nuclear factor-?
Negative_regulation (inhibition) of factor
20) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2551692 Disease Relevance 1.60 Pain Relevance 0.74

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox